ChemicalBook > CAS DataBase List > 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole

1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole

Product Name
1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole
CAS No.
74257-00-4
Chemical Name
1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole
Synonyms
MSNT;1-(MESITYLENE-2-SULFONYL)-3-NITRO-1H-1,2,4-TRIAZOLE;1-(Mesitylsulfonyl)-3-nitro-1H-1,2,4-triazole;MSNT Novabiochem;TIMTEC-BB SBB005917;1-(Mesitylene-2-sulf;1-(Mesitylene-2-sulfonyl)-3-nitro-1;1-(2-MESITYLENESULFONYL)-3-NITRO-1 2 4-&;Mesitylenesulfonyl-3-nitro-1H-2,4,6-triazole;1-(Mesitylene-2-Sulfonyl)-3-Nitro-1,2,-Triazole
CBNumber
CB5773297
Molecular Formula
C11H12N4O4S
Formula Weight
296.3
MOL File
74257-00-4.mol
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1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole Property

Melting point:
134-139 °C(lit.)
Boiling point:
533.4±60.0 °C(Predicted)
Density 
1.4470 (rough estimate)
refractive index 
1.6270 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in Chloroform.
pka
-5.80±0.50(Predicted)
form 
Crystalline Powder
color 
Yellow
BRN 
4328921
InChI
InChI=1S/C11H12N4O4S/c1-7-4-8(2)10(9(3)5-7)20(18,19)14-6-12-11(13-14)15(16)17/h4-6H,1-3H3
InChIKey
SFYDWLYPIXHPML-UHFFFAOYSA-N
SMILES
N1(S(C2=C(C)C=C(C)C=C2C)(=O)=O)C=NC([N+]([O-])=O)=N1
CAS DataBase Reference
74257-00-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
241784
Product name
1-(2-Mesitylenesulfonyl)-3-nitro-1H-1,2,4-triazole
Purity
98%
Packaging
1g
Price
$146
Updated
2023/01/07
TRC
Product number
M258750
Product name
1-(2-Mesitylenesulfonyl)-3-nitro-1H-1,2,4-triazole
Packaging
5g
Price
$90
Updated
2021/12/16
Matrix Scientific
Product number
094019
Product name
1-(Mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole
Purity
98%
Packaging
25g
Price
$98
Updated
2021/12/16
AK Scientific
Product number
H199
Product name
1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole
Packaging
25g
Price
$121
Updated
2021/12/16
Ark Pharm
Product number
P000173069
Product name
1-(Mesitylsulfonyl)-3-nitro-1H-1,2,4-triazole
Purity
97%
Packaging
1g
Price
$7
Updated
2021/12/16
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1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Solid

Uses

Condensing reagent for oligonucleotide synthesis.

Uses

This reagent was originally used as a coupling reagent in phosphotriester oligonucleotide synthesis

Uses

An efficient coupling reagent in oligonucleotide synthesis by the phosphotriesters approach

Synthesis

773-64-8

24807-55-4

74257-00-4

An oven-dried 1.0-liter round-bottomed flask equipped with a magnetic stirring bar was assembled with a Claisen adapter. To the reaction flask was added 3-nitro-1,2,4-triazole (19.5 g, 0.171 mol), anhydrous dioxane (200 mL), and triethylamine (17.3 g, 0.171 mol, 1.0 eq.), and the solution was cooled to 0°C. A 200 mL pressure-equalizing dosing funnel was assembled through the Claisen adapter, and a dioxane solution (150 mL) of homotrimethylbenzenesulfonyl chloride ( 37.4 g, 0.171 mol) of dioxane solution (150 mL) to the funnel. Slowly add the homotrimethylbenzenesulfonyl chloride solution dropwise to the reaction mixture. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 0.5 hours, followed by warming to room temperature and continued stirring for 1 hour. After completion of the reaction, the precipitated triethylamine hydrochloride was removed by filtration and the filtrate was concentrated under reduced pressure to give a yellow solid. The solid was dissolved in dichloromethane (150 mL) and the organic layer was washed with water (150 mL). The organic layer was dried with anhydrous sodium sulfate, filtered and the solvent evaporated under reduced pressure to give a yellow solid. Recrystallization by boiling toluene (20-30 mL) followed by washing with ice-cold toluene and drying overnight at 1.9 mmHg gave 1-(2-trimethylbenzenesulfonyl)-3-nitro-1,2,4-triazole 24-25 g (46%-48% yield) as a pale yellow solid with a melting point of 131°C-133°C (literature values 130°C-132°C). Thin Layer Chromatography (TLC) Rf = 0.23 (unfolding agent: dichloromethane solution of 20% hexane, UV detection).1H NMR (300 MHz, CDCl3) δ: 8.84 (s, 1H), 7.07 (s, 2H), 2.69 (s, 6H), 2.34 (s, 3H).13C NMR (75 MHz, CDCl3) δ. 162.9, 147.5, 145.2, 142.5, 133.0, 127.9, 23.2, 21.3. IR (solid) νmax: 3126, 2983, 2947, 1597 cm-1. Calculated elemental values (C11H12N4O4S): C, 44.59; H, 4.08; N, 18.91. Measured values: C , 44.69; H, 3.88; N, 18.72. The purity of the product was determined to be 96% by reversed-phase high-performance liquid chromatography (RP-HPLC), with a retention time of tR = 8.41 min (detection wavelength 254 nm).

References

[1] Organic Preparations and Procedures International, 2014, vol. 46, # 3, p. 267 - 271
[2] Tetrahedron Letters, 1986, vol. 27, # 45, p. 5529 - 5532

1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole Suppliers

Belgium 1 Canada 1 China 143 France 1 Germany 3 India 3 Japan 2 Switzerland 1 Ukraine 1 United Kingdom 5 United States 28 Global 189
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VWR International
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View Lastest Price from 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole 74257-00-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-07
Hebei Chuanghai Biotechnology Co., Ltd
Product
1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole 74257-00-4
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Henan Aochuang Chemical Co.,Ltd.
Product
1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole 74257-00-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-26

74257-00-4, 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazoleRelated Search:

Triphenylphosphine 1,2,4-Triazole 3-SULFOLENE 1-Phenyl-2-nitropropene 2,4-Dimethylbenzenethiol p-Toluenesulfonamide (S)-4-Methylbezenesulfinamide 1-(p-Toluenesulfonyl)-3-nitro-1,2,4-triazole 2,6-DIMETHYLTHIOPHENOL 2,4,6-TRIMETHYLTHIOPHENOL 1-MESITYLENESULFONYL-1,2,4-TRIAZOLE 3-Nitro-1,2,4-triazole 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole NITROGEN DIOXIDE Phenylacetone 2-Methylbenzene-1-sulfonamide (R)-(-)-4-Methylbezenesulfinamide Nitromethane

  • 1-(MESITYLENE-2-SULFONYL)-3-NITRO-1,2,4-TRIAZOLE
  • 1-(MESITYLENE-2-SULFONYL)-3-NITRO-1H-1,2,4-TRIAZOLE
  • (2,4,6-TRIMETHYLPHENYL) (3-NITRO-1,2,4-TRIAZOL-1-YL) SULFONE
  • 2,4,6-TRIMETHYLBENZENESULFONYL-3-NITROTRIAZOLIDE
  • 1-(2-MESITYLENESULFONYL)-3-NITRO-1H-1,2,4-TRIAZOLE
  • MSNT
  • TIMTEC-BB SBB005917
  • 1-(2,4,6-Trimethylphenylsulfonyl)-3-nitro-1,2,4-triazole
  • 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,-triazole(MSNT)
  • 1H-1,2,4-Triazole,3-nitro-1-[(2,4,6-trimethylphenyl)sulfonyl]-
  • 3-nitro-1-(2,4,6-trimethylphenyl)sulfonyl-1,2,4-triazole
  • 1-(Mesitylene-2-Sulfonyl)-3-Nitro-1,2,-Triazole
  • 1-(2-MESITYLENESULFONYL)-3-NITRO-1 2 4-&
  • (2,4,6-Trimethylphenyl) (3-nitro-1,2,4-triazol-1-yl) sulfone, MSNT
  • Mesitylenesulfonyl-3-nitro-1H-2,4,6-triazole
  • 1-(Mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole/MSNT
  • 1-(2,4,6-Trimethylphenylsulfonyl)-3-nitro-1H-1,2,4-triazole
  • 1-(Mesitylsulfonyl)-3-nitro-1H-1,2,4-triazole
  • 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole,98%
  • 1-(Mesitylene-2-sulf
  • 1-(Mesitylene-2-sulfonyl-3-nitro-1,2,4-triazoleMSNT
  • 3-Nitro-1-[(2,4,6-triMethylphenyl)sulfonyl]-1H-1,2,4-triazole
  • 1-(2-Mesitylenesulfonyl)-3-nitro-1H-1,2,4-triazole, 99+%
  • 1-(Mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole≥ 99% (HPLC)
  • MSNT Novabiochem
  • 1-(2-Mesitylenesulfonyl)-3-nitro-1H-1,2,4-triazole, 99+% white to yellow solid
  • 1-(Mesitylene-2-sulfonyl)-3-nitro-1
  • 1-(tritolyl-2-sulfone) -3-nitro-1,2, 4-triazole
  • 74257-00-4
  • 24257-00-4
  • 74257-80-4
  • C11H12N4O4S
  • Triazoles
  • Heterocyclic Building Blocks
  • Building Blocks
  • Building Blocks
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Triazoles
  • Miscellaneous Reagents
  • Bases & Related Reagents
  • Nucleotides