DY131

Product Name: DY131
CAS No.: 95167-41-2
Chemical Name: DY131
Synonyms: DY131;GW4716;CS-889;GSK4716;CS-2176;GW574716;GSK 9089;DY-131; DY 131;DY131(GSK 9089);DY-131 SK 9089
CBNumber: CB5774966
Molecular Formula: C18H21N3O2
Formula Weight: 311.38
MOL File: 95167-41-2.mol

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DY131 Property

Melting point:: 234-236 °C
Density: 1.11±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: ≥14 mg/mL
form: solid
pka: 8.47±0.15(Predicted)
color: yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D3946
Product name: DY 131
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $90
Updated: 2024/03/01

Sigma-Aldrich

Product number: D3946
Product name: DY 131
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $338
Updated: 2023/01/07

Alfa Aesar

Product number: J65171
Product name: DY 131
Packaging: 10mg
Price: $213
Updated: 2023/06/20

Cayman Chemical

Product number: 17999
Product name: DY 131
Purity: ≥98%
Packaging: 5mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 17999
Product name: DY 131
Purity: ≥98%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

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DY131 Chemical Properties,Usage,Production

Description

DY131 (95167-41-2) is a selective agonist at estrogen-related receptors ERRβ and ERRγ with minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.1?Displays antiproliferative activity in prostate cancer cells.2?Promotes hormone production and cell fusion in cytotrophoblasts.3?In breast cancer cells DY131 arrests cells in G2/M and causes mitotic spindle defects.4?Inhibits osteoclastogenesis and protects against inflammatory bone loss induced by LPS?in vivo.5

Uses

DY131 is a selective estrogen-related receptors (ERRβ and ERRγ) agonist (1,2). It is also an antimitotic agent that inhibits breast cancer cell growth.

Definition

ChEBI: N-[[4-(diethylamino)phenyl]methylideneamino]-4-hydroxybenzamide is a member of benzoic acids.

Biological Activity

Novel selective agonist at estrogen-related receptors ERR β and ERR γ . Displays minimal activity at ERR α , ER α and ER β at concentrations up to 30 μ M.

in vitro

dy131 was evaluated for its selectivity and efficacy in modulating the transcriptional activity of errα/β/γ and erβ/γ. cv-1 cells were transfected with reporter constructs or expression vectors and the fold activation of the reporter construct was determined at different concentrations of dy131. dy131 was found to be not able to activate the reporter construct or errα at any of the tested concentrations. in contrast, dy131 led to three- to fourfold activation of errβ at concentrations of 10-30 μm. activity on errγ was more pronounced with five-fold activation at 3 μm and maximal 6.6-fold activity observed at 30 μm. thus, dy131 was an selective errβ/γ ligand displaying preferential selectivity for errγ at lower concentrations [1].

storage

+4°C

References

1) Yu and Forman (2005),?Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma; Bioorg. Med. Chem. Lett.,?15?1311 2) Yu?et al.?(2008),?Orphan nuclear receptor estrogen-related receptor-beta suppresses in vitro and in vivo growth of prostate cancer cells via p21 (WAF1/CIP1) induction and as a potential therapeutic target in prostate cancer; Oncogene,?27?3313 3) Poidatz?et al. (2015),?Trophoblast syncytialisation necessitates mitochondrial function through estrogen-related receptor-τ; Mol. Hum. Reprod.,?21?206 4) Heckler?et al.?(2016),?Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERR?2) splice variant in breast cancer; Oncotarget,?7?47201 5) Kim?et al.?(2019),?Estrogen-related receptor τ negatively regulates osteoclastogenesis and protects against inflammatory bone loss; J. Cell Physiol.,?234?1659

DY131 Preparation Products And Raw materials

Raw materials

Preparation Products

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DY131 Suppliers

China 76 Germany 2 India 1 Switzerland 1 United Kingdom 2 United States 19 Global 101

VDM Biochemicals

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MedChemexpress LLC

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EMMX Biotechnology LLC

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Target molecule Corp.

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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Aladdin Scientific

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View Lastest Price from DY131 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: DY131 95167-41-2
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10
Release date: 2024-08-24

Career Henan Chemical Co

Product: DY131 95167-41-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

95167-41-2, DY131Related Search:

PF-01367338 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide Levetiracetam NORFLUOXETINE HYDROCHLORIDE DY131

GSK 9089

DY131(GSK 9089)

4-Hydroxybenzoic acid 2-[[4-(diethylamino)phenyl]methylene]hydrazide

DY131;DY-131;DY 131

GSK4716

GW4716

GW574716

DY131

N'-(4-DIETHYLAMINOBENZYLIDENE)-4-HYDROXYBENZOYLHYDRAZIDE

N-(4-(DIETHYLAMINOBENZYLIDENYL))-N'-(4-HYDROXYBENZOYL)-HYDRAZINE

(E)-N'-(4-(diethylamino)benzylidene)-4-hydroxybenzohydrazide

CS-2176

CS-889

DY-131; DY 131

N'-{(1E)-[4-(diethylamino)phenyl]methylene}-4-hydroxybenzohydrazide

GSK 9089;DY-131;DY 131;GSK9089;GSK-9089

Benzoic acid, 4-hydroxy-, 2-[[4-(diethylamino)phenyl]methylene]hydrazide

N'-(4-(Diethylamino)benzylidene)-4-hydroxybenzohydrazide

(E)-N'-(4-(diethylamino)benzylidene)-4-hydroxybenzohydrazide

N'-(4-(Diethylamino)benzylidene)-4-hydroxybenzohydrazide

DY-131 SK 9089

95167-41-2

Steroid Hormones

Hormones

Estrogen

Cytokines, Growth Factors and Hormones

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Inhibitors

Intracellular receptor

Novel selective agonist at estrogen-related receptors ERRβ and ERRγ.