2-(4-BENZYLPIPERAZINO)BENZALDEHYDE

Product Name: 2-(4-BENZYLPIPERAZINO)BENZALDEHYDE
CAS No.: 112253-26-6
Chemical Name: 2-(4-BENZYLPIPERAZINO)BENZALDEHYDE
Synonyms: 2-(4-BENZYLPIPERAZINO)BENZALDEHYDE;1-Benzyl-4-(2-formylphenyl)piperazine;2-(4-BENZYLPIPERAZIN-1-YL)BENZALDEHYDE;2-(4-BENZYLPIPERAZINO)BENZENECARBALDEHYDE;2-(4-BENZYLPIPERAZIN-1-YL)BENZALDEHYDE, 95+%;2-[4-(Phenylmethyl)-1-piperazinyl]benzaldehyde;Benzaldehyde, 2-[4-(phenylmethyl)-1-piperazinyl]-;2-[4-(phenylmethyl)-1-piperazin-4-iumyl]benzaldehyde;2-(4-BENZYLPIPERAZINO)BENZALDEHYDE ISO 9001：2015 REACH
CBNumber: CB5781094
Molecular Formula: C18H20N2O
Formula Weight: 280.36
MOL File: 112253-26-6.mol

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2-(4-BENZYLPIPERAZINO)BENZALDEHYDE Property

Melting point:: 58 °C
Boiling point:: 429.9±45.0 °C(Predicted)
Density: 1.155±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 7.46±0.10(Predicted)
CAS DataBase Reference: 112253-26-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B289218
Product name: 2-(4-Benzylpiperazin-1-yl)benzaldehyde
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR29343
Product name: 2-(4-Benzylpiperazin-1-yl)benzaldehyde
Packaging: 1g
Price: $49
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H15-1-W4
Product name: 2-(4-Benzylpiperazin-1-yl)benzaldehyde
Packaging: 1g
Price: $58
Updated: 2021/12/16

Matrix Scientific

Product number: 046043
Product name: 2-(4-Benzylpiperazino)benzenecarbaldehyde
Purity: >95%
Packaging: 500mg
Price: $118
Updated: 2021/12/16

Matrix Scientific

Product number: 046043
Product name: 2-(4-Benzylpiperazino)benzenecarbaldehyde
Purity: >95%
Packaging: 1g
Price: $151
Updated: 2021/12/16

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2-(4-BENZYLPIPERAZINO)BENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

2759-28-6

446-52-6

112253-26-6

Example 3: Synthesis of 1-[4-(1-methoxy-1-methyl-ethyl)-phenyl]-3-(2-piperazin-1-yl-benzo-D-pyrrolidin-2-one (Compound 12) Step 1: 25 g of 1-benzylpiperazine (1) and 10 g of 2-fluorobenzaldehyde (2) were reacted in refluxing dioxane/water (1:2, total volume 90 mL) in the presence of 17 g of K2CO3 for 24 hours. After completion of the reaction, the mixture was cooled to room temperature and extracted with dichloromethane. The organic layer was washed sequentially with water, 5% hydrochloric acid and brine, followed by drying with magnesium sulfate, filtration and concentration in vacuum. Purification by silica gel column chromatography (eluent: 5:1 hexane-ethyl acetate) afforded 20 g of 2-(4-benzylpiperazin-1-yl)benzaldehyde (3) in 89% yield; mass spectrum (AP/CI): m/z 281.1 ([M+H]+, 100%). Step 2: 8 g of 2-(4-benzylpiperazin-1-yl)benzaldehyde (3) was reacted with 4.6 g of NaH (60% mineral oil dispersion) at room temperature for 1 h. Subsequently, 7.3 g of 1-acetyl-pyrrolidin-2-one (4) was added, warmed up to room temperature and stirring was continued for 2 hours. The reaction solution was carefully quenched with methanol at 0°C and the solvent was removed in vacuum. The residue was diluted with water and extracted with dichloromethane. The organic layer was washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuum. Purification by silica gel column chromatography (eluent: 40:1 chloroform-methanol) afforded 7.9 g of 3-[2-(4-benzylpiperazin-1-yl)-benzylidene]-pyrrolidin-2-one (5) in 80% yield; mass spectrum (AP/CI): m/z 348.1 ([M+H]+, 100%). Step 3: 6.3 g of 3-[2-(4-benzylpiperazin-1-yl)-benzylidene]-pyrrolidin-2-one (5) was catalytically hydrogenated with 1.5 g of Pd/C in 100 mL of methanol at 50 psi. Upon completion of the reaction, it was filtered and concentrated in vacuum to afford 3.8 g of 3-(2-piperazin-1-yl-benzylidene)-pyrrolidin-2-one (6) in 82% yield; purified by silica gel column chromatography (eluent: 30:1:0.3 chloroform-methanol-ammonium hydroxide); mass spectrum (AP/CI): m/z 260.1 ([M+H]+, 100%). Step 4: 1.2 g of 3-(2-piperazin-1-yl-benzyl)-pyrrolidin-2-one (6) was mixed with 0.041 g of N,N'-dimethylethylenediamine, 0.088 g of CuI, and 0.96 g of K2CO3 in 6 mL of toluene, and 1.27 g of 1-bromo-4-(1-methoxy-1-methyl- ethyl)-benzene (11) was added, and reacted for 17 h at 110 °C . After completion of the reaction, purification by silica gel column chromatography (eluent: 40:1:0.5 chloroform-methanol-ammonium hydroxide) afforded 1.2 g of the racemate 1-[4-(1-methoxy-1-methylethyl)-phenyl]-3-(2-piperazin-1-yl-benzyl)-pyrrolidin-2-one (12), in 64% yield; mass spectrum (AP/CI): m/z 408.2 ([M +H]+).

References

[1] Patent: WO2006/75226, 2006, A1. Location in patent: Page/Page column 23
[2] Synthesis, 1987, # 7, p. 641 - 645

2-(4-BENZYLPIPERAZINO)BENZALDEHYDE Preparation Products And Raw materials

Raw materials

PIPERAZINE DIHYDROCHLORIDE Benzyl chloride 2-Fluorobenzaldehyde Ethanol PIPERAZINE HEXAHYDRATE N,N-Dimethylformamide Sodium sulfate Potassium carbonate Chloroform Ammonium chloride Ethyl acetate Dichloromethane Methanol Sodium hydroxide 1-Benzylpiperazine

Preparation Products

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2-(4-BENZYLPIPERAZINO)BENZALDEHYDE Suppliers

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View Lastest Price from 2-(4-BENZYLPIPERAZINO)BENZALDEHYDE manufacturers

Dideu Industries Group Limited

Product: 2-(4-BENZYLPIPERAZINO)BENZALDEHYDE 112253-26-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-23

Career Henan Chemical Co

Product: 2-(4-BENZYLPIPERAZINO)BENZALDEHYDE 112253-26-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-19

112253-26-6, 2-(4-BENZYLPIPERAZINO)BENZALDEHYDERelated Search:

Benzaldehyde 4-(4-BENZYLPIPERAZINO)BENZALDEHYDE 2-(4-BENZYL-PIPERAZIN-1-YL)-BENZOIC ACID METHYL ESTER 2-(4-BENZYLPIPERAZINO)BENZALDEHYDE 2-(4-[BIS(4-FLUOROPHENYL)METHYL]PIPERAZIN-1-YL)BENZALDEHYDE RARECHEM AL BI 0460 2-(4-BENZYL-1-PIPERAZINO)-5-FLUORO-BENZALDEHYDE 2-(4-BENZYL-1-PIPERAZINO)-5-BROMO-BENZALDEHYDE 2-(4-BENZYL-1-PIPERAZINO)-3-FLUORO-BENZALDEHYDE METHYL 5-AMINO-2-(4-BENZYLPIPERAZINO)BENZENECARBOXYLATE 2-(4-BENZYL-1-PIPERAZINO)-4-BROMO-BENZALDEHYDE 2-(4-BENZYL-PIPERAZIN-1-YL)-BENZOIC ACID METHYL 2-(4-BENZYLPIPERAZINO)-5-NITROBENZENECARBOXYLATE

2-(4-BENZYLPIPERAZINO)BENZALDEHYDE

2-(4-BENZYLPIPERAZINO)BENZENECARBALDEHYDE

2-(4-BENZYLPIPERAZIN-1-YL)BENZALDEHYDE

2-(4-BENZYLPIPERAZIN-1-YL)BENZALDEHYDE, 95+%

1-Benzyl-4-(2-formylphenyl)piperazine

2-[4-(phenylmethyl)-1-piperazin-4-iumyl]benzaldehyde

Benzaldehyde, 2-[4-(phenylmethyl)-1-piperazinyl]-

2-(4-BENZYLPIPERAZINO)BENZALDEHYDE ISO 9001：2015 REACH

2-[4-(Phenylmethyl)-1-piperazinyl]benzaldehyde

112253-26-6