ChemicalBook > CAS DataBase List > (+)-5,6-O-Isopropylidene-L-ascorbic acid

(+)-5,6-O-Isopropylidene-L-ascorbic acid

Product Name
(+)-5,6-O-Isopropylidene-L-ascorbic acid
CAS No.
15042-01-0
Chemical Name
(+)-5,6-O-Isopropylidene-L-ascorbic acid
Synonyms
5,6-ISOPROPYLIDENE-L-ASCORBIC ACID;5,6-O-ISOPROPYLIDENE-L-ASCORBIC ACID;(R)-5-((S)-2,2-Dimethyl-1,3-dioxolan-4-yl)-3,4-dihydroxyfuran-2(5H)-one;Iasa;NSC 252042;(+)-5,6-O-Isopropyli;L-Ascorbicacidacetonide;ASCORBIC ACID ACETONIDE;Isopropylidene ascorbic acid;5,5-ISOPROPYLIDENE-L-ASCORBIC ACID
CBNumber
CB5783467
Molecular Formula
C9H12O6
Formula Weight
216.19
MOL File
15042-01-0.mol
More
Less

(+)-5,6-O-Isopropylidene-L-ascorbic acid Property

Melting point:
217 °C (dec.)
Boiling point:
395.2±42.0 °C(Predicted)
alpha 
10.5 º (c=5%, MeOH)
Density 
1.518±0.06 g/cm3(Predicted)
refractive index 
10 ° (C=5, MeOH)
storage temp. 
2-8°C
solubility 
Acetone, DMSO, Ethanol, Methanol
form 
Solid
pka
3.99±0.10(Predicted)
color 
Off-White
optical activity
[α]19/D +25.3°, c = 1 in H2O
BRN 
86893
InChI
InChI=1S/C9H12O6/c1-9(2)13-3-4(15-9)7-5(10)6(11)8(12)14-7/h4,7,10-11H,3H2,1-2H3/t4-,7+/m0/s1
InChIKey
POXUQBFHDHCZAD-MHTLYPKNSA-N
SMILES
OC1=C(O)C(=O)O[C@@H]1[C@@H]1COC(O1)(C)C
CAS DataBase Reference
15042-01-0(CAS DataBase Reference)
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10-21
HS Code 
2932990090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
301361
Product name
5,6-Isopropylidene-L-ascorbic acid
Purity
98%
Packaging
5g
Price
$53.62
Updated
2025/07/31
TCI Chemical
Product number
I0507
Product name
(+)-5,6-O-Isopropylidene-L-ascorbic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$145
Updated
2025/07/31
TCI Chemical
Product number
I0507
Product name
(+)-5,6-O-Isopropylidene-L-ascorbic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$577
Updated
2025/07/31
TRC
Product number
A787000
Product name
AscorbicAcidAcetonide
Packaging
5g
Price
$60
Updated
2021/12/16
Usbiological
Product number
A3774-90
Product name
Ascorbic Acid Acetonide
Packaging
10g
Price
$355
Updated
2021/12/16
More
Less

(+)-5,6-O-Isopropylidene-L-ascorbic acid Chemical Properties,Usage,Production

Chemical Properties

White Powder

Uses

5,6-O-Isopropylidene-L-ascorbic acid (L-Ascorbic acid 5,6-acetonide) is an organic compound. 5,6-O-Isopropylidene-L-ascorbic acid is a derivative of L-Ascorbic acid (vitamin C). Ascorbic acid has antioxidant properties.

Synthesis

50-81-7

15042-01-0

General procedure for the synthesis of 5,6-O-isopropylidene-L-ascorbic acid from vitamin C: Vitamin C (1.76 g, 10 mmol) and acetone (9 mL) were added to a reaction flask fitted with a magnetic stirrer and stirred until dissolved. Subsequently, phosphoryl chloride (0.5 mL) was added slowly and dropwise to the above solution. The reaction mixture was stirred continuously for 4 hours at room temperature. After completion of the reaction, the mixture was filtered, and the filter cake was washed with cold acetone-water (volume ratio adjusted according to the actual situation), and finally dried under vacuum to obtain the target compound 5,6-O-isopropylidene-L-ascorbic acid (1.92 g, 89% yield) as a colorless granular solid. The product was detected by IR (KBr press method) and the main absorption peaks were: νmax 3242.6, 2993.3, 2907.6, 2741.6, 1755.5, 1665.4 cm-1. 1H NMR (600 MHz, CD3COCD3) data: δ 4.71-4.73 (m, 1H, C4-H), 4.37-4.39 ( m, 1H, C5-H), 4.16-4.21 (m, 1H, C6-H), 3.99-4.03 (m, 1H, C6-H), 1.29 (s, 6H, Me).

References

[1] Pappenberger G, et al. Industrial production of L-ascorbic Acid (vitamin C) and D-isoascorbic acid. Adv Biochem Eng Biotechnol. 2014;143:143-88. DOI:10.1007/10_2013_243

(+)-5,6-O-Isopropylidene-L-ascorbic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(+)-5,6-O-Isopropylidene-L-ascorbic acid Suppliers

Americas 1 Austria 1 Canada 2 China 119 Europe 1 France 2 Germany 5 India 4 Japan 2 Switzerland 2 The Netherlands 1 United Kingdom 15 United States 27 Global 182
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
Clearsynth Labs
Tel
--
Fax
--
Email
fo@clearsynth.com
Country
India
ProdList
3887
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
More
Less

View Lastest Price from (+)-5,6-O-Isopropylidene-L-ascorbic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
(+)-5,6-O-Isopropylidene-L-ascorbic acid 15042-01-0
Price
US $0.00/G
Min. Order
10G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
(+)-5,6-O-Isopropylidene-L-ascorbic acid 15042-01-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
(+)-5,6-O-Isopropylidene-L-ascorbic acid 15042-01-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-02

15042-01-0, (+)-5,6-O-Isopropylidene-L-ascorbic acidRelated Search:

2,2-Dimethyl-1,3-dioxolane-4-methanol Sodium ascorbate Calcium ascorbate dihydrate ISOPROPYLMAGNESIUM CHLORIDE Sodium erythorbate Ascorbic Acid Ascoric Acid 2-ETHOXYETHYL ACRYLATE 1-ETHOXY-2-PROPYL ACETATE 2(5H)-Furanone 2-METHYL-1,3-DIOXOLANE (2-ISOPROPOXYETHYL) ACETATE 2,4-DIMETHYL, 1,3-DIOXALONE 2-Hydroxyethyl acrylate DL-ascorbic acid (S)-(-)HYDROXYMETHYL-3(2H)-FURANONE 4-Hydroxy-2(5H)-furanone (2-Propenyloxy)propanol

  • (+)-5,6-O-Isopropyli
  • NSC 252042
  • 5,6-O-ISOPROPYLIDENE-L-ASCORBIC ACID
  • 5,6-ISOPROPYLIDENE-L-ASCORBIC ACID
  • 5,5-ISOPROPYLIDENE-L-ASCORBIC ACID
  • (R)-5-((S)-2,2-Dimethyl-1,3-dioxolan-4-yl)-3,4-dihydroxyfuran-2(5H)-one
  • 5,6-Isopropylidene-L-ascorbic acid 98%
  • ASCORBIC ACID ACETONIDE
  • 5,6-0,0-ISOPROPYLIDENE-L-ASCORBIC ACID
  • L-Ascorbicacidacetonide
  • L-Ascorbic acid, 5,6-O-(1-methylethylidene)-
  • (+)-5,6-O-ISOPROPYLIDENE-L-ASCORBIC ACID 99+%
  • 5-O,6-O-Isopropylidene-L-ascorbic acid
  • Iasa
  • Isopropylidene ascorbic acid
  • 5,6-Isopropylidene-L-ascorbic acid,(+)-5,6-O-Isopropylidene-L-ascorbic acid
  • 5,6-isopropyridene-L-ascorbic acid
  • 2-(2,2-dimethyl-1,3-dioxolan-4-yl)-4,5-dihydroxy-3-furanone
  • (+)-5,6-O-Isopropylidene-L-ascorbicAcid&gt
  • (+)-5,6-O-Isopropylidene-L-ascorbic acid
  • (2R)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3,4-dihydroxy-2H-furan-5-one
  • 5,6-Isopropylidene-<sc>L</sc>-ascorbic acid
  • 15042-01-0
  • 15042-01-07
  • Sugar Acids
  • O-Substituted Sugars
  • Sugars
  • Monosaccharides
  • Specialty Synthesis
  • Carbohydrate Synthesis
  • Heterocycles
  • 13C & 2H Sugars
  • Biochemistry
  • O-Substituted Sugars
  • Sugar Acids
  • Sugars
  • Vitamin Derivatives
  • Vitamins
  • Carbohydrates & Derivatives
  • Vitamins and Derivatives