5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE
- Product Name
- 5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE
- CAS No.
- 886365-56-6
- Chemical Name
- 5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE
- Synonyms
- 2-AMINO-5-FLUORO-3-PICOLINE;5-Fluoro-3-methylpyridin-2-amine;5-fluoro-3-Methyl-2-pyridinaMine;2-Amino-5-fluoro-3-methylpyridine;2-Pyridinamine, 5-fluoro-3-methyl-;5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE;5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE ISO 9001：2015 REACH
- CBNumber
- CB5798511
- Molecular Formula
- C6H7FN2
- Formula Weight
- 126.13
- MOL File
- 886365-56-6.mol
5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- color
- Cream
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F598088
- Product name
- 5-Fluoro-3-methylpyridin-2-ylamine
- Packaging
- 1g
- Price
- $310
- Updated
- 2021/12/16
- Product number
- HCH0142735
- Product name
- 5-FLUORO-3-METHYLPYRIDIN-2-YLAMINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $327.6
- Updated
- 2021/12/16
- Product number
- 3H30-3-6Z
- Product name
- 5-Fluoro-3-methylpyridin-2-ylamine
- Purity
- 98%
- Packaging
- 5G
- Price
- $786
- Updated
- 2021/12/16
- Product number
- 073036
- Product name
- 5-Fluoro-3-methylpyridin-2-ylamine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $869
- Updated
- 2021/12/16
- Product number
- 3H30-3-6Z
- Product name
- 5-Fluoro-3-methylpyridin-2-ylamine
- Purity
- 98%
- Packaging
- 10g
- Price
- $1293
- Updated
- 2021/12/16
5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE Chemical Properties,Usage,Production
Synthesis
38186-84-4
886365-56-6
To a solution of 2-chloro-3-methyl-5-fluoropyridine (0.50 g, 2.82 mmol) in anhydrous toluene (12.5 mL) was added sequentially sodium tert-butoxide (0.462 g, 4.81 mmol), tris(dibenzylideneacetone)dipalladium (0.315 g, 0.344 mmol), 2,2'-bis(diphenylphosphinato)-1,1'-binaphthyl ( BINAP, 0.642 g, 1.031 mmol) and benzophenoneimine (0.692 mL, 4.12 mmol). The reaction mixture was degassed (three evacuation/nitrogen filling cycles) and subsequently heated to 80 °C and stirred for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ether (400 mL) and filtered through a pad of diatomaceous earth. The filtrate was concentrated under reduced pressure and the residue was dissolved in tetrahydrofuran (34 mL) and 2 M aqueous hydrochloric acid (1.408 mL, 2.82 mmol) was added. After stirring for 1.5 h at room temperature, the reaction mixture was neutralized with saturated aqueous sodium bicarbonate and diluted with dichloromethane (200 mL). The aqueous phase was back-extracted with dichloromethane (2 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by rapid chromatography on silica gel (Biotage SP4 12M, cyclohexane/ethyl acetate 60/40). The target fraction was collected to give 2-amino-3-methyl-5-fluoropyridine (0.20 g, 1.554 mmol, 55.2% overall yield in two steps) as an orange solid. Mass spectrum (electrospray positive ion mode) m/z: 127 ([M+H]+). Elemental analysis calculated value (C6H7FN2): 126.1. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 7.73 (d, 1H), 7.23 (dd, 1H), 5.60 (broad peak, 2H), 2.04 (s, 3H).
References
[1] Patent: US2009/22670, 2009, A1. Location in patent: Page/Page column 20
[2] Patent: WO2010/72722, 2010, A1. Location in patent: Page/Page column 27
5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE manufacturers
- Product
- 5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE 886365-56-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE 886365-56-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-19