Alatrofloxacin

Product Name: Alatrofloxacin
CAS No.: 146961-76-4
Chemical Name: Alatrofloxacin
Synonyms: D07562;Alatrofloxacin (inn);UUZPPAMZDFLUHD-VUJLHGSVSA-N;L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-;L-Alanyl-N-[(1alpha,5alpha,6alpha)-3-[6-Carboxy-8-(2,4-Difluorophenyl)-3-Fluoro-5,8-Dihydro-5-Oxo-1,8-Naphthyridin-2-Yl]-3-Azabicyclo[3.1.0]Hex-6-Yl]-L-Alaninamide
CBNumber: CB11102904
Molecular Formula: C26H25F3N6O5
Formula Weight: 558.51
MOL File: 146961-76-4.mol

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Alatrofloxacin Property

Boiling point:: 863.2±65.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
pka: 5.80±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0015025
Product name: 7-[(1R,5S)-6-([(2S)-1-([(2S)-2-AMINOPROPANOYL]AMINO)-1-OXOPROPAN-2-YL]AMINO)-3-AZABICYCLO[3.1.0]HEXAN-3-YL]-1-(2,4-DIFLUOROPHENYL)-6-FLUORO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC?ACID
Purity: 95.00%
Packaging: 5MG
Price: $502.43
Updated: 2021/12/16

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Alatrofloxacin Chemical Properties,Usage,Production

Definition

ChEBI: Alatrofloxacin is a peptide.

Enzyme inhibitor

This fourth-generation fluoroquinolone-class antibiotic (FW = 558.51 g/mol; CAS 146961-76-4; quickly hydrolyzes to form trovafloxacin), also named 7-[(1R,5S)-6-{[(2S)-1-{[(2S)-2-aminopropanoyl]amino}-1-oxopropan- 2-yl]amino}-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6- fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid, is a systemic antibacterial that targets Type II DNA topoisomerases (gyrases) required for bacterial replication and transcription. This fluoroquinolone shows an extensive in vitro antibiotic spectrum, with high activity against Grampositive coccus, anaerobic and atypical pneumonia-producing bacteria. (For the prototypical member of this antibiotic class, See Ciprofloxacin) Intravenous alatrofloxacin, followed by oral trovafloxacin (TVX), is safe and well tolerated. Alatrofloxacin also lacks the phototoxicity, cardiovascular toxicity, and hemolytic anemia associated with earlier fluoroquinolones. Given its metabolism to trovafloxacin, it should be noted that the latter significantly increases the formation of nitrotyrosine in mice that are heterozygous for mitochondrial superoxide dismutase-2. Using the NO-selective probe DAF-2, TVX also increases the production of mitochondrial NO in immortalized human hepatocytes. Similarly, mitochondrial Ca2+ is increased by TVX, suggesting calcium ion-dependent activation of mitochondrial NOS activity. The relationship between these observations and trovafloxacin-induced leukopenia remains to be explored.

Alatrofloxacin Preparation Products And Raw materials

Raw materials

Preparation Products

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Alatrofloxacin Suppliers

China 6 United States 2 Global 8

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Finetech Industry Limited

Tel: +86-27-87465837 +8618971612321
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9639
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 22784
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29811
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 19704
Advantage: 58

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19885
Advantage: 58

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View Lastest Price from Alatrofloxacin manufacturers

Dideu Industries Group Limited

Product: Alatrofloxacin 146961-76-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-21

Career Henan Chemical Co

Product: Alatrofloxacin 146961-76-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10t
Release date: 2019-12-20

146961-76-4, AlatrofloxacinRelated Search:

6-PIPERIDIN-1-YLNICOTINALDEHYDE 5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE TROVAFLOXACIN 3-azabicyclo[3.1.0]hexane 3-Fluoro-5-methylpyridine Alatrofloxacin Ethanone,1-(5-fluoro-3-pyridinyl)- 3-FLUORO-5-FORMYLPYRIDINE 2-Amino-5-fluoropyridine 2-AMINO-N-CYCLOPROPYL-ACETAMIDE 6-(1-PYRROLIDINYL)NICOTINALDEHYDE 2-Amino-3-fluoropyridine 2-Amino-3-acetylpyridine 2,6-Diamino-3-fluoropyridine

Alatrofloxacin (inn)

D07562

UUZPPAMZDFLUHD-VUJLHGSVSA-N

L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-

L-Alanyl-N-[(1alpha,5alpha,6alpha)-3-[6-Carboxy-8-(2,4-Difluorophenyl)-3-Fluoro-5,8-Dihydro-5-Oxo-1,8-Naphthyridin-2-Yl]-3-Azabicyclo[3.1.0]Hex-6-Yl]-L-Alaninamide

146961-76-4

C26H25F3N6O5