2-Amino-5-fluoropyridine
- Product Name
- 2-Amino-5-fluoropyridine
- CAS No.
- 21717-96-4
- Chemical Name
- 2-Amino-5-fluoropyridine
- Synonyms
- 5-FLUOROPYRIDIN-2-AMINE;2-Amino-5-fL;Risdiplam Impurity 13;Amino-5-fluoropyridine;5-FLUORO-2-PYRIDINAMINE;5-fluoro-2-aminepyridin;Lemborexant Impurity 24;5-FLUORO-2-AMINOPYRIDINE;2-Amino-5-fluoropyridine;2-Amine-5-fluoropyridine
- CBNumber
- CB8471590
- Molecular Formula
- C5H5FN2
- Formula Weight
- 112.11
- MOL File
- 21717-96-4.mol
2-Amino-5-fluoropyridine Property
- Melting point:
- 93-97 °C (lit.)
- Boiling point:
- 125 °C
- Density
- 1.257±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- pka
- 4.62±0.13(Predicted)
- form
- Powder
- color
- White to orange
- BRN
- 385938
- InChI
- InChI=1S/C5H5FN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8)
- InChIKey
- YJTXQLYMECWULH-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(F)C=C1
- CAS DataBase Reference
- 21717-96-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 36/37/38-34
- Safety Statements
- 26-36-45-36/37/39-27
- RIDADR
- UN2811
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29333999
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 518689
- Product name
- 2-Amino-5-fluoropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $25.1
- Updated
- 2025/07/31
- Product number
- 518689
- Product name
- 2-Amino-5-fluoropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $230
- Updated
- 2023/06/20
- Product number
- A1664
- Product name
- 2-Amino-5-fluoropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- A1664
- Product name
- 2-Amino-5-fluoropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $156
- Updated
- 2025/07/31
- Product number
- A608450
- Product name
- 2-Amino-5-fluoropyridine
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
2-Amino-5-fluoropyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
2-Amino-5-fluoropyridine is used in chemical microarrays to identify ligands that binds pathogenic cells. Acts as a reagent in the preparation of heterocyclic compounds as integrase inhibiting antiviral agents.
Definition
ChEBI: 2-Amino-5-fluoropyridine is a dihydropyridine.
Application
2-Amino-5-fluoropyridine is a versatile fluorinated pyridine building block widely used to prepare peptide deformylase inhibitors such as the antibacterial agent LBM415, as well as herbicides, fungicides, and PET imaging probes; the combined electron-withdrawing fluorine and nucleophilic amino substituents enhance metabolic stability and bioavailability of the resulting active pharmaceutical or agrochemical ingredients.
Synthesis
2-Amino-5-fluoropyridine is an important intermediate for the synthesis of LBM415 which is the peptide deformylas inhibitor. Using 2-aminopyridine as raw material and via nitrification, amino acetylation, reduction of nitro, diazolization, Schiemann reaction and hydrolysis of acetyl.
References
[1] E. S. HAND, D. C. BAKER. “ChemInform Abstract: Syntheses of 2-Chloro- and 2-Amino-5-fluoropyridines and Isolation of a Novel Difluoroboryl Imidate.” ChemInform 21 19 (1990).
2-Amino-5-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-5-fluoropyridine Suppliers
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View Lastest Price from 2-Amino-5-fluoropyridine manufacturers
- Product
- 2-Amino-5-fluoropyridine 21717-96-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-20
- Product
- 2-Amino-5-fluoropyridine 21717-96-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 2-Amino-5-fluoropyridine 21717-96-4
- Price
- US $0.00/gm
- Min. Order
- 100gm
- Purity
- 99%min
- Supply Ability
- 100kgs
- Release date
- 2024-09-04