ChemicalBook > CAS DataBase List > 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE

5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE

Product Name
5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
CAS No.
114744-50-2
Chemical Name
5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
Synonyms
5-bromo-1,2,3,4-tetrahydroquinoline;Quinoline, 5-bromo-1,2,3,4-tetrahydro-;5-bromo-1,2,3,4-tetrahydroquinoline HCl;5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE1HCL SALT;5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
CBNumber
CB5802137
Molecular Formula
C9H10BrN
Formula Weight
212.09
MOL File
114744-50-2.mol
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5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE Property

Boiling point:
300℃
Density 
1.428
Flash point:
135℃
storage temp. 
2-8°C(protect from light)
pka
4.19±0.20(Predicted)
Appearance
Light yellow to brown Liquid
InChI
InChI=1S/C9H10BrN/c10-8-4-1-5-9-7(8)3-2-6-11-9/h1,4-5,11H,2-3,6H2
InChIKey
WTZQIKXLRRDMCP-UHFFFAOYSA-N
SMILES
N1C2=C(C(Br)=CC=C2)CCC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
B415723
Product name
5-Bromo-1,2,3,4-tetrahydroquinoline
Packaging
500mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB71823
Product name
5-Bromo-1,2,3,4-tetrahydroquinoline
Packaging
500mg
Price
$150
Updated
2021/12/16
AK Scientific
Product number
2430AA
Product name
5-Bromo-1,2,3,4-tetrahydroquinoline
Packaging
1g
Price
$166
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB71823
Product name
5-Bromo-1,2,3,4-tetrahydroquinoline
Packaging
1g
Price
$220
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB71823
Product name
5-Bromo-1,2,3,4-tetrahydroquinoline
Packaging
100mg
Price
$60
Updated
2021/12/16
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5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

15115-60-3

114744-50-2

General procedure for the synthesis of 5-bromo-1,2,3,4-tetrahydroquinoline from 4-bromoinden-1-one: 4-bromoinden-1-one (1.05 g, 5 mmol) was dissolved in methanol (14 ml), hydroxylamine hydrochloride (1.4 g, 20 mmol) was added, and the reaction was carried out at reflux for 1 hour. After completion of the reaction, vacuum concentration was carried out followed by addition of dichloromethane and 50% sodium bicarbonate solution and stirring for 20 min. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated to give a white solid in 99% yield. The white solid (5 mmol) obtained above was dissolved in dichloromethane (30 ml), cooled to 0 °C and diisobutylaluminum hydride (20 ml, 30 mmol, 1.5 M toluene solution) was added slowly. The reaction mixture was stirred at 0°C for 30 min, then moved to room temperature and continued stirring overnight. After completion of the reaction, the reaction was quenched with water under ice bath conditions, extracted with dichloromethane, the organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. After concentration, it was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 3:1) to give 600 mg of 5-bromo-1,2,3,4-tetrahydroquinoline as a pale yellow solid in 56.6% yield.

References

[1] Patent: CN107814785, 2018, A. Location in patent: Paragraph 0062; 0081; 0082; 0083

5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE Suppliers

China 79 India 1 Switzerland 1 United Kingdom 1 United States 6 Global 88
Alchem Pharmtech,Inc.
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View Lastest Price from 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE 114744-50-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-11

114744-50-2, 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDERelated Search:

5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 5,6,7,8-Tetrahydroquinoxaline Quinoline 1,2,3,4-Tetrahydrocarbazole 5,6,7,8-Tetrahydroquinoline 5,6,7,8-TETRAHYDROISOQUINOLINE 1,2,3,4-Tetrahydroquinoline QUINOLINE HYDROCHLORIDE 3-Bromo-2-methylaniline, HCl 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE

  • 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
  • 5-bromo-1,2,3,4-tetrahydroquinoline
  • 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE1HCL SALT
  • 5-bromo-1,2,3,4-tetrahydroquinoline HCl
  • Quinoline, 5-bromo-1,2,3,4-tetrahydro-
  • 114744-50-2