Etrolizumab

Product Name: Etrolizumab
CAS No.: 1044758-60-2
Chemical Name: Etrolizumab
Synonyms: Etrolizumab;rhuMAb Beta7;Etrolizumab (anti-α4β7);Research Grade Etrolizumab;Research Grade Etrolizumab(DHC98803)
CBNumber: CB58080827
Formula Weight: 0
MOL File: Mol file

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Etrolizumab Property

storage temp.: Store at -20°C
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Etrolizumab Chemical Properties,Usage,Production

Uses

Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7 integrin monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with Ki values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD)[1][2].

in vivo

Etrolizumab (rhuMAb Beta7; 5 mg/kg; i.v.; once; normal female BALB/c mice) decreases β7 integrins on T lymphocytes^[2].
Etrolizumab (200 μg (100 μL); i.p.; once) inhibits lymphocyte homing in the CD45RB^high T cell-reconstituted SCID mouse model of colitis^[2].

Animal Model:	Normal female BALB/c mice (17-21 g)^[2]
Dosage:	5 mg/kg
Administration:	Intravenous injection; once
Result:	Had 98.3% of intraepithelial CD8⁺ T-cell β7 integrin receptors and 90.0% of intraepithelial CD4⁺ T-cell β7 integrin receptors after 24 h.

Animal Model:	SCID mouse model of colitis^[2]
Dosage:	200 μg (100 μL)
Administration:	Intraperitoneal injection; once
Result:	Blocked lymphocyte recruitment and homing to the inflamed colon.

IC 50

α4β7; αEβ7

References

[1] Tang MT, et, al. Review article: nonclinical and clinical pharmacology, pharmacokinetics and pharmacodynamics of etrolizumab, an anti-β7 integrin therapy for inflammatory bowel disease. Aliment Pharmacol Ther. 2018 Jun;47(11):1440-1452. DOI:10.1111/apt.14631
[2] Stefanich EG, et, al. A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes. Br J Pharmacol. 2011 Apr;162(8):1855-70. DOI:10.1111/j.1476-5381.2011.01205.x

Etrolizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Etrolizumab Suppliers

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1044758-60-2, EtrolizumabRelated Search:

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Etrolizumab

Research Grade Etrolizumab(DHC98803)

rhuMAb Beta7

Etrolizumab (anti-α4β7)

Research Grade Etrolizumab

1044758-60-2