Tildrakizumab
- Product Name
- Tildrakizumab
- CAS No.
- 1326244-10-3
- Chemical Name
- Tildrakizumab
- Synonyms
- Tildrakizumab;MK 3222|||SCH 900222;Tildrakizumab (anti-IL-23a);Research Grade Tildrakizumab;Research Grade Tildrakizumab(DHJ63102)
- CBNumber
- CB58080872
- Formula Weight
- 0
- MOL File
- Mol file
Tildrakizumab Property
- form
- Liquid
- color
- Colorless to light yellow
Tildrakizumab Chemical Properties,Usage,Production
Uses
Tildrakizumab (SCH 900222) is a humanized anti-IL-23 (p19 subunit) monoclonal antibody. IL-23 is a critical cytokine to maintain the Th17 cell phenotype. Tildrakizumab has high-affinity for single-chain IL-23 (Kd: 136 pM). Tildrakizumab is effective against moderate to severe plaque psoriasis[1][2][3].
in vivo
Tildrakizumab (100?mg/kg, s.c., every 2 weeks up to 9 months) is well tolerated in cynomolgus monkeys (toxicity studies)[3].
References
[1] Papp K, et al. Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial. Br J Dermatol. 2015 Oct;173(4):930-9. DOI:10.1111/bjd.13932
[2] Zhou L, et al. A non-clinical comparative study of IL-23 antibodies in psoriasis. MAbs. 2021 Jan-Dec;13(1):1964420. DOI:10.1080/19420862.2021.1964420
[3] Santostefano M, et al. Nonclinical safety of tildrakizumab, a humanized anti-IL-23p19 monoclonal antibody, in nonhuman primates. Regul Toxicol Pharmacol. 2019 Nov;108:104476. DOI:10.1016/j.yrtph.2019.104476
Tildrakizumab Preparation Products And Raw materials
Raw materials
Preparation Products
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