ChemicalBook > CAS DataBase List > Monalizumab
Monalizumab
- Product Name
- Monalizumab
- CAS No.
- 1228763-95-8
- Chemical Name
- Monalizumab
- Synonyms
- Monalizumab;Monalizumab (anti-NKG2A);Research Grade Monalizumab;Research Grade Monalizumab(DHD71901)
- CBNumber
- CB58080948
- Formula Weight
- 0
- MOL File
- Mol file
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Monalizumab Property
- storage temp.
- Store at -20°C
- form
- Liquid
- color
- Colorless to light yellow
- Water Solubility
- Soluble in water
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Monalizumab Chemical Properties,Usage,Production
Uses
Monalizumab (IPH2201) is a potentially first-in-class immune checkpoint inhibitor targeting NKG2A receptors expressed on tumor infiltrating cytotoxic CD8+ T cells and NK cells.
Mechanism of action
Monalizumab is a blocking antibody that prevents the inhibition of CD8+ T cells and NK cell by tumor cells expressing HLA-E. By acting simultaneously on innate and adaptive immunity, monalizumab may re-establish a broad anti-tumor response.
in vivo
Monalizumab (50 ?μg, intratumoral injections, together with 8?millions of activated NK cells) effectively inhibits tumor growth in xenografted HLA-E+ tumors in immunodeficient mice[4].
| Animal Model: | immunodeficient mice xenografted with Cal-27 HLA-E high tumor cell[4] |
| Dosage: | 50?μg, together with 8?millions of activated NK cells |
| Administration: | intratumoral injections |
| Result: | Shows a synergestic antitumor effect. Enhanced NK-cell killing, and induces lysis of tumor cells. |
Monalizumab Preparation Products And Raw materials
Raw materials
Preparation Products
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