ChemicalBook > CAS DataBase List > 4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-
4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-
- Product Name
- 4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-
- CAS No.
- 1226443-41-9
- Chemical Name
- 4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-
- Synonyms
- HQ461;HQ461, 10 mM in DMSO;4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-;2-(2-((6-methylpyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide;N-(5-methyl-1,3-thiazol-2-yl)-2-{2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl}acetamide;cyclin K degrader,Cyclin dependent kinase,molecular glue,HQ461,HQ 461,HQ-461,CDK12 substrate phosphorylation,inhibit,CDK,Inhibitor,Molecular Glues,DNA damage
- CBNumber
- CB58119666
- Molecular Formula
- C15H15N5OS2
- Formula Weight
- 345.44
- MOL File
- 1226443-41-9.mol
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4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)- Property
- Density
- 1.436±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- form
- Solid
- pka
- 8.11±0.50(Predicted)
- color
- Gray to light brown
- InChI
- InChI=1S/C15H15N5OS2/c1-9-4-3-5-12(17-9)19-15-18-11(8-22-15)6-13(21)20-14-16-7-10(2)23-14/h3-5,7-8H,6H2,1-2H3,(H,16,20,21)(H,17,18,19)
- InChIKey
- QMRBCNQCRMTXBE-UHFFFAOYSA-N
- SMILES
- S1C=C(CC(NC2=NC=C(C)S2)=O)N=C1NC1=NC(C)=CC=C1
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4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)- Chemical Properties,Usage,Production
Uses
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death[1].
References
[1] Lv L, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife. 2020 Aug 17;9:e59994. DOI:10.7554/eLife.59994
4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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4-Thiazoleacetamide, 2-[(6-methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)- Suppliers
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