Ifebemtinib

Product Name: Ifebemtinib
CAS No.: 1227948-82-4
Chemical Name: Ifebemtinib
Synonyms: IN10018;Ifebemtinib;IN10018（BI853520）;Ifebemtinib (BI-853520);IN10018(BI853520,Ifebemtinib);Ifebemtinib/BI-853520/IN-10018;2-Fluoro-5-methoxy-4-[[4-[(2-methyl-3-oxo-4-isoindolinyl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-N-(1-methyl-4-piperidyl)benzamide;2-Fluoro-5-methoxy-4-((4-((2-methyl-3-oxoisoindolin-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide;2-Fluoro-5-methoxy-4-((4-((2-methyl-3-oxoisoindolin-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide , Ifebemtinib;Benzamide, 4-[[4-[(2,3-dihydro-2-methyl-3-oxo-1H-isoindol-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)-
CBNumber: CB58180967
Molecular Formula: C28H28F4N6O4
Formula Weight: 588.55
MOL File: 1227948-82-4.mol

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Ifebemtinib Property

Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 13.19±0.20(Predicted)
form: Solid
color: White to off-white
InChIKey: ULMMVBPTWVRPSI-UHFFFAOYSA-N
SMILES: C(NC1CCN(C)CC1)(=O)C1=CC(OC)=C(NC2=NC=C(C(F)(F)F)C(OC3=CC=CC4=C3C(=O)N(C)C4)=N2)C=C1F

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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Ifebemtinib Chemical Properties,Usage,Production

Uses

Ifebemtinib (BI 853520) is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC50=1 nM). Ifebemtinib shows anti-proliferative activity against cancer cells. Ifebemtinib inhibits FER Kinase and FES Kinase with IC50s of 900 nM and 1040 nM, respectively[1][2][3].

in vivo

Ifebemtinib (BI 853520) (oral gavage; 50 mg/kg; once daily; 0-8 weeks) treatment significantly suppresses primary tumor growth of all three cell lines in vivo^[1].

Animal Model:	FVB/N, Balb/c, or immunodeficient nude (nu/nu) mice transplanted with Py2T, 4T1, or MTflECad cells, respectively^[1]
Dosage:	50 mg/kg
Administration:	Oral gavage; 50 mg/kg; once daily; 0-8 weeks
Result:	Decreased tumor volume significantly over time.

References

[1] Hirt UA, et al. Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype. Oncogenesis. 2018 Feb 23;7(2):21. DOI:10.1038/s41389-018-0032-z
[2] Stefanie Tiede, et al. The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer. Oncogenesis. 2018 Sep 20;7(9):73. DOI:10.1038/s41389-018-0083-1

Ifebemtinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Ifebemtinib Suppliers

China 40 United States 1 Global 41

Shanghai Zhiyun Biotechnology Co., Ltd

Tel: 13119135307
Country: China
ProdList: 2767
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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1150
Advantage: 64

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 2586
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Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 9955
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Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
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Changzhou Yongfeng Biomedicine Co. Ltd.

Tel: 15006117673
Fax: 2973592490@.com
Email: 2973592490@qq.com
Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 1141
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1227948-82-4, IfebemtinibRelated Search:

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Benzamide, 4-[[4-[(2,3-dihydro-2-methyl-3-oxo-1H-isoindol-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)-

IN10018（BI853520）

IN10018

Ifebemtinib (BI-853520)

Ifebemtinib

Ifebemtinib/BI-853520/IN-10018

2-Fluoro-5-methoxy-4-[[4-[(2-methyl-3-oxo-4-isoindolinyl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-N-(1-methyl-4-piperidyl)benzamide

2-Fluoro-5-methoxy-4-((4-((2-methyl-3-oxoisoindolin-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide , Ifebemtinib

2-Fluoro-5-methoxy-4-((4-((2-methyl-3-oxoisoindolin-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide

IN10018(BI853520,Ifebemtinib)

1227948-82-4

227948-82-4