Conteltinib (CT-707)

Product Name: Conteltinib (CT-707)
CAS No.: 1384860-29-0
Chemical Name: Conteltinib (CT-707)
Synonyms: CT-707;Conteltinib (CT-707);Conteltinib, 10 mM in DMSO;N-Isopropyl-2-[[2-[[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidyl]phenyl]amino]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzenesulfonamide;N-Isopropyl-2-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzenesulfonamide;Benzenesulfonamide, 2-[[6,7-dihydro-2-[[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-N-(1-methylethyl)-;N-Isopropyl-2-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzenesulfonamide , Conteltinib
CBNumber: CB94844661
Molecular Formula: C32H45N9O3S
Formula Weight: 635.82
MOL File: 1384860-29-0.mol

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Conteltinib (CT-707) Property

Boiling point:: 814.7±75.0 °C(Predicted)
Density: 1.283±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 31.25 mg/mL (49.15 mM)
form: Solid
pka: 11.74±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0039261
Product name: Conteltinib
Purity: 99.47%
Packaging: 5mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0039261
Product name: Conteltinib
Purity: 99.47%
Packaging: 10mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0039261
Product name: Conteltinib
Purity: 99.47%
Packaging: 50mg
Price: $1250
Updated: 2021/12/16

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Conteltinib (CT-707) Chemical Properties,Usage,Production

Uses

Conteltinib (CT-707) is a multi-kinase inhibitor targeting FAK, ALK, and Pyk2. Conteltinib exerts significant inhibitory effect on FAK with an IC50 of 1.6 nM[1].

in vivo

The combination of XL184 (20 mg/kg once daily for first 3 days; i.g. 10 mg/kg once a day for 4th day; no administration from 5th to 10th days; i.g. 10 mg/kg once a day from the 10th to 14th days )and CT-707 (i.g. 50 mg/kg twice a day for first 3 days, 7th, 8th, 11th, 12th, and 14th days; once a day for 4th, 6th, 9th, 10th, and 13th days; no administration for the 5th day) shows the synergistic antitumor effect in HepG2 xenograft nude mice^[1].

Animal Model:	Nude mice transplanted with HepG2 xenografts^[1]
Dosage:	50 mg/kg
Administration:	Intragastrically (i.g.) twice a day for first 3 days, 7th, 8th, 11th, 12th, and 14th days; once a day for 4th, 6th, 9th, 10th, and 13th days; no administration for the 5th day.
Result:	Caused a moderate decrease in the relative tumor volume (RTV). The inhibition rate of combination group reached 77.4%, whereas the mono-treatment of XL184 or CT-707 alone caused 30.7% and 19.4% inhibition in the tumor weight, respectively.

References

[1] Wang DD, et al. CT-707, a Novel FAK Inhibitor, Synergizes with XL184 to Suppress Hepatocellular Carcinoma by Blocking XL184-Induced FAK Activation. Mol Cancer Ther. 2016 Dec;15(12):2916-2925. DOI:10.1158/1535-7163.MCT-16-0282

Conteltinib (CT-707) Preparation Products And Raw materials

Raw materials

Preparation Products

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Conteltinib (CT-707) Suppliers

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1384860-29-0, Conteltinib (CT-707)Related Search:

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Conteltinib (CT-707)

CT-707

Benzenesulfonamide, 2-[[6,7-dihydro-2-[[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-N-(1-methylethyl)-

N-Isopropyl-2-[[2-[[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidyl]phenyl]amino]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzenesulfonamide

N-Isopropyl-2-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzenesulfonamide , Conteltinib

N-Isopropyl-2-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzenesulfonamide

Conteltinib, 10 mM in DMSO

1384860-29-0

C32H45N9O3S