Polymyxin B nonapeptide TFA
- Product Name
- Polymyxin B nonapeptide TFA
- CAS No.
- 2220175-42-6
- Chemical Name
- Polymyxin B nonapeptide TFA
- Synonyms
- Polymyxin B nonapeptide TFA;(2S,3R)-2-Amino-N-((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((R)-1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)-3-hydroxybutanamide 2,2,2-trifluoroacetate
- CBNumber
- CB58205871
- Molecular Formula
- C45H75F3N14O13
- Formula Weight
- 1077.18
- MOL File
- 2220175-42-6.mol
Polymyxin B nonapeptide TFA Property
- storage temp.
- Store at -20°C,protect from light
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water: 100 mg/mL (65.22 mM)
- Sequence
- Thr-{Dab}-{Dab}-{Dab}-{d-Phe}-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9)
N-Bromosuccinimide Price
- Product number
- CS-0128232
- Product name
- PolymyxinBnonapeptide(TFA)
- Purity
- 99.80%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0128232
- Product name
- PolymyxinBnonapeptide(TFA)
- Purity
- 99.80%
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0128232
- Product name
- PolymyxinBnonapeptide(TFA)
- Purity
- 99.80%
- Packaging
- 50mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- CS-0128232
- Product name
- PolymyxinBnonapeptide(TFA)
- Purity
- 99.80%
- Packaging
- 100mg
- Price
- $1650
- Updated
- 2021/12/16
Polymyxin B nonapeptide TFA Chemical Properties,Usage,Production
Uses
Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[1][2][3].
in vivo
Polymyxin B nonapeptide TFA (1.5, 3.0 mg/kg intravenously for 29 days) does not exhibit neuromuscular blocking, neurotoxic, or nephrotoxic effects in rats as observed with polymyxin B sulfate[2].
References
[1] Al-Marzooq F, et al. Discerning the role of polymyxin B nonapeptide in restoring the antibacterial activity of azithromycin against antibiotic-resistant Escherichia coli. Front Microbiol. 2022 Sep 21;13:998671. DOI:10.3389/fmicb.2022.998671
[2] Danner RL,et al. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother. 1989 Sep;33(9):1428-34. DOI:10.1128/AAC.33.9.1428
[3] Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7. DOI:10.1128/AAC.38.2.374
Polymyxin B nonapeptide TFA Preparation Products And Raw materials
Raw materials
Preparation Products
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