Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-
- Product Name
- Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-
- CAS No.
- 2451481-08-4
- Chemical Name
- Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-
- Synonyms
- sulfopin;1-dioxido-3-thienyl)-;sulfopin, 10 mM in DMSO;2-dimethylpropyl)-N-(tetrahydro-1;2-Chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide;Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-;neuroblastoma,antiproliferative,PIN1-3,tumors,cancer,pancreatic,Inhibitor,sulfopin,inhibit,cells,HEK293
- CBNumber
- CB58215081
- Molecular Formula
- C11H20ClNO3S
- Formula Weight
- 281.8
- MOL File
- 2451481-08-4.mol
Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Property
- Boiling point:
- 455.5±45.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- solid
- pka
- -1.36±0.20(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 028490
- Product name
- Sulfopin
- Packaging
- 001
- Price
- $350
- Updated
- 2021/12/16
Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Chemical Properties,Usage,Production
Description
Sulfopin (2451481-08-4) is a potent and selective covalent inhibitor of peptidyl-prolyl isomerase NIMA interacting-1 (Pin1) (Ki = 17 nM).1 Although it displayed little to no cytotoxicity against a panel of 300 cancer cell lines, it had a significant impact on cancer cell growth after prolonged treatment. It suppressed MYCN-driven neuroblastoma initiation and the growth and survival of primary neuroblastoma tumor cell transplants in zebrafish.
References
Dubiella et al. (2021), Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo; Nat. Cham. Biol. 17 954
Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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