11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE

Product Name: 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
CAS No.: 123548-16-3
Chemical Name: 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
Synonyms: AQ-RA 741;AQ-RA 741, M2 antagonist;11-[[4-[4-(Diethylamino)butyl]piperidin-1-yl]acetyl]-11H-pyrido[2,3-b][1,4]benzodiazepin-6(5H)-one;11-(2-(4-(4-(Diethylamino)butyl)piperidin-1-yl)acetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one;11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE;5,11-Dihydro-11-[[4-[4-(diethylamino)butyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one;6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 11-[2-[4-[4-(diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-
CBNumber: CB5840317
Molecular Formula: C27H37N5O2
Formula Weight: 463.61
MOL File: 123548-16-3.mol

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11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Property

Boiling point:: 602.7±50.0 °C(Predicted)
Density: 1.132±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: <46.36mg/ml in 1eq. HCl; <46.36mg/ml in ethanol; <46.36mg/ml in DMSO
form: solid
pka: 11.29±0.20(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2292
Product name: AQ-RA741
Purity: ≥99%(HPLC)
Packaging: 10
Price: $167
Updated: 2021/12/16

Tocris

Product number: 2292
Product name: AQ-RA741
Purity: ≥99%(HPLC)
Packaging: 50
Price: $683
Updated: 2021/12/16

Usbiological

Product number: 254659
Product name: AQ-RA 741
Packaging: 10mg
Price: $409
Updated: 2021/12/16

TRC

Product number: A735440
Product name: AQ-RA741
Packaging: 50mg
Price: $580
Updated: 2021/12/16

ApexBio Technology

Product number: B7003
Product name: AQ-RA741
Packaging: 10mg
Price: $251
Updated: 2021/12/16

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11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Chemical Properties,Usage,Production

Uses

AQ-RA 741 acts as a potent and highly specific muscarinic M2 receptor antagonist, with potential application towards the development of bronchodilator anti-muscarinic agents for humans.

Definition

ChEBI: 11-[2-[4-[4-(diethylamino)butyl]-1-piperidinyl]-1-oxoethyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one is a benzodiazepine.

Biological Activity

High affinity, selective muscarinic M 2 receptor antagonist (pK i values are 8.3, 7.7 and 6.82 for M 2 , M 1 and M 3 receptors, respectively). In vivo, displays cardioselectivity over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia.

storage

Store at RT

References

[1]. doods h, entzeroth m and mayer n. cardioselectivity of aq-ra 741, a novel tricyclic antimuscarinic drug. eur j pharmacol, 1991, 192(1):147-52.
[2]. gomeza j, shannon h, kostenis e, et al. pronounced pharmacologic deficits in m2 muscarinic acetylcholine receptor knockout mice. proc natl acad sci u s a, 1999, 96(4):1692-7.

11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Suppliers

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123548-16-3, 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONERelated Search:

11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE 3-Amino-2-phenylamino-pyridine 2-amino-N-(3-pyridinyl)benzamide 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one

11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE

AQ-RA 741

11-(2-(4-(4-(Diethylamino)butyl)piperidin-1-yl)acetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

11-[[4-[4-(Diethylamino)butyl]piperidin-1-yl]acetyl]-11H-pyrido[2,3-b][1,4]benzodiazepin-6(5H)-one

5,11-Dihydro-11-[[4-[4-(diethylamino)butyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 11-[2-[4-[4-(diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-

AQ-RA 741, M2 antagonist

123548-16-3

C27H37N5O2

Acetylcholine receptor

Muscarinic