METHYL 2-FLUORO-4-HYDROXYBENZOATE

Product Name: METHYL 2-FLUORO-4-HYDROXYBENZOATE
CAS No.: 197507-22-5
Chemical Name: METHYL 2-FLUORO-4-HYDROXYBENZOATE
Synonyms: METHYL 2-FLUORO-4-HYDROXYBENZOATE;Methyl2-fluoro-4-hydroxybenzoate,98%;Methyl 2-fluoro-4-hydroxybenzoate 98%;2-Fluoro-4-hydroxybenzoic acid methyl ester;BENZOIC ACID, 2-FLUORO-4-HYDROXY-, METHYL ESTER
CBNumber: CB5841677
Molecular Formula: C8H7FO3
Formula Weight: 170.14
MOL File: Mol file

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METHYL 2-FLUORO-4-HYDROXYBENZOATE Property

Boiling point:: 287℃
Density: 1.309
Flash point:: 127℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: crystalline powder
pka: 7.36±0.18(Predicted)
color: Off white to faint gold
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C8H7FO3/c1-12-8(11)6-3-2-5(10)4-7(6)9/h2-4,10H,1H3
InChIKey: WYSPMXSNCAFCFV-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(O)C=C1F

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Safety

HS Code: 2918290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: F591855
Product name: 2-Fluoro-4-hydroxybenzoicAcidMethylEster
Packaging: 10g
Price: $1320
Updated: 2021/12/16

Matrix Scientific

Product number: 074868
Product name: Methyl 2-fluoro-4-hydroxybenzoate
Purity: 95+%
Packaging: 5g
Price: $128
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044055
Product name: METHYL 2-FLUORO-4-HYDROXYBENZOATE
Purity: 95.00%
Packaging: 1G
Price: $1034.88
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044055
Product name: METHYL 2-FLUORO-4-HYDROXYBENZOATE
Purity: 95.00%
Packaging: 5G
Price: $2067.45
Updated: 2021/12/16

Matrix Scientific

Product number: 074868
Product name: Methyl 2-fluoro-4-hydroxybenzoate
Purity: 95+%
Packaging: 1g
Price: $42
Updated: 2021/12/16

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METHYL 2-FLUORO-4-HYDROXYBENZOATE Chemical Properties,Usage,Production

Uses

Methyl 2-fluoro-4-hydroxybenzoate can be used in the preparation of compounds, with the ability to inhibit cytosolic phospholipase A2α. It is also an intermediate in the synthesis of 3-(2-fluoro-4-hydroxyphenyl)-5-(trifluoromethyl) -4-isoxazolecarboxylic acid methyl ester (F591865).

Synthesis

67-56-1

65145-13-3

197507-22-5

General procedure for the synthesis of methyl 2-fluoro-4-hydroxybenzoate from methanol and 2-fluoro-4-hydroxybenzoic acid: Referring to Example 10 of the literature; 2-fluoro-4-hydroxybenzoic acid (50.0 g) was dissolved in methanol (700 mL), concentrated sulfuric acid (10 mL) was added as a catalyst, and the reaction was carried out with heating and stirring for 16 hrs. at 90 °C. After the reaction was completed, the reaction solution was concentrated, and the resulting colorless crystals were washed with water and dried to obtain the target product methyl 2-fluoro-4-hydroxybenzoate (51 g, 94% yield) as colorless crystals. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 3.79 (3H, s), 6.61-6.72 (2H, m), 7.73-7.79 (1H, m), 10.80 (1H, br).

References

[1] Patent: EP2392573, 2011, A1. Location in patent: Page/Page column 39
[2] Patent: EP2522657, 2012, A1. Location in patent: Page/Page column 36-37
[3] Patent: WO2010/45258, 2010, A2. Location in patent: Page/Page column 140; 141
[4] Patent: WO2009/111056, 2009, A1. Location in patent: Page/Page column 212
[5] ChemMedChem, 2013, vol. 8, # 5, p. 779 - 799

METHYL 2-FLUORO-4-HYDROXYBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 2-FLUORO-4-HYDROXYBENZOATE Suppliers

China 91 India 4 Switzerland 1 United Kingdom 4 United States 12 Global 112

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197507-22-5, METHYL 2-FLUORO-4-HYDROXYBENZOATERelated Search:

Calcium carbonate Silicon dioxide Barium hydroxide Carbon dioxide Pyrrole Ferric sulfate Sodium hydroxide Iron oxide 2'-Hydroxy-3-phenylpropiophenone (S)-(+)-Benzyl glycidyl ether Vanillin Salicylic acid ALUMINUM CHLOROHYDRATE Perfluorotributylamine Methanol Titanium dioxide Methyl 3,4-dihydroxybenzoate Propylene glycol

METHYL 2-FLUORO-4-HYDROXYBENZOATE

BENZOIC ACID, 2-FLUORO-4-HYDROXY-, METHYL ESTER

2-Fluoro-4-hydroxybenzoic acid methyl ester

Methyl 2-fluoro-4-hydroxybenzoate 98%

Methyl2-fluoro-4-hydroxybenzoate,98%

197507-22-5

Aromatic Esters

Fluorine series