ChemicalBook > CAS DataBase List > 1H-CINNOLIN-4-ONE

1H-CINNOLIN-4-ONE

Product Name: 1H-CINNOLIN-4-ONE
CAS No.: 18514-84-6
Chemical Name: 1H-CINNOLIN-4-ONE
Synonyms: 1H-CINNOLIN-4-ONE;4(1H)-Cinnolinone;[1,8]NAPHTHYRIDIN-4-OL;1,4-dihydrocinnolin-4-one
CBNumber: CB5846379
Molecular Formula: C8H6N2O
Formula Weight: 146.15
MOL File: 18514-84-6.mol

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1H-CINNOLIN-4-ONE Property

storage temp.: Sealed in dry,Room Temperature
Appearance: Brown to reddish brown Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C465370
Product name: Cinnolin-4(1H)-one
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C465370
Product name: Cinnolin-4(1H)-one
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: W4006
Product name: 1H-Cinnolin-4-one
Packaging: 1g
Price: $101
Updated: 2021/12/16

ChemScene

Product number: CS-W022612
Product name: Cinnolin-4(1H)-one
Purity: 98.48%
Packaging: 5g
Price: $121
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC139702
Product name: Cinnolin-4(1H)-one
Packaging: 500mg
Price: $140
Updated: 2021/12/16

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1H-CINNOLIN-4-ONE Chemical Properties,Usage,Production

Synthesis Reference(s)

Synthesis, p. 288, 1987 DOI: 10.1055/s-1987-27921

Synthesis

551-93-9

18514-84-6

General procedure for the synthesis of 1H-cinnolin-4-one from o-aminoacetophenone: Preparation of Intermediate 1: 1,4-dihydro-4-quinolinone: An aqueous solution (10 mL) of sodium nitrite (4.0 g, 59 mmol) was slowly added dropwise over 20 min to a stirred mixture of 2-aminoacetophenone (5.0 g, 37.03 mmol) with concentrated hydrochloric acid (31 mL) under ice bath cooling conditions. The reaction mixture was continued to be stirred at the same temperature for 2 hours, then brought to room temperature and stirred overnight. After completion of the reaction, the mixture was concentrated under reduced pressure. The residue was neutralized with aqueous sodium acetate and then subjected to post-extraction treatment (ethyl acetate/brine) to give the final 1H-cinnolin-4-one (1.25 g, 23% yield). 1H-NMR (δ ppm, DMSO-d6, 300 MHz): 13.48 (br.s, 1H); 8.01 (d, J = 8.1 Hz, 1H); 7.82-7.73 (m, 2H); 7.57 (d, J = 8.1 Hz, 1H); 7.41 (t, J = 7.8 Hz, 1H).

References

[1] Heterocycles, 2008, vol. 75, # 1, p. 77 - 86
[2] Australian Journal of Chemistry, 1981, vol. 34, # 12, p. 2619 - 2627
[3] Patent: WO2009/53799, 2009, A1. Location in patent: Page/Page column 28-29
[4] Journal of the Chemical Society, 1947, p. 917,920

1H-CINNOLIN-4-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-CINNOLIN-4-ONE Suppliers

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18514-84-6, 1H-CINNOLIN-4-ONERelated Search:

CINOXACIN (4-OXOCINNOLIN-1(4H)-YL)ACETIC ACID 6-bromocinnolin-4(1H)-one 3-(4-OXOCINNOLIN-1(4H)-YL)PROPANOIC ACID 3-BROMO-1-ETHYL-1,4-DIHYDRO[1,3]DIOXOLO[4,5-G]CINNOLIN-4-ONE 1H-CINNOLIN-4-ONE

1H-CINNOLIN-4-ONE

[1,8]NAPHTHYRIDIN-4-OL

4(1H)-Cinnolinone

1,4-dihydrocinnolin-4-one

18514-84-6