1H-CINNOLIN-4-ONE
- Product Name
- 1H-CINNOLIN-4-ONE
- CAS No.
- 18514-84-6
- Chemical Name
- 1H-CINNOLIN-4-ONE
- Synonyms
- 1H-CINNOLIN-4-ONE;4(1H)-Cinnolinone;[1,8]NAPHTHYRIDIN-4-OL;1,4-dihydrocinnolin-4-one
- CBNumber
- CB5846379
- Molecular Formula
- C8H6N2O
- Formula Weight
- 146.15
- MOL File
- 18514-84-6.mol
1H-CINNOLIN-4-ONE Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Brown to reddish brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C465370
- Product name
- Cinnolin-4(1H)-one
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C465370
- Product name
- Cinnolin-4(1H)-one
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W4006
- Product name
- 1H-Cinnolin-4-one
- Packaging
- 1g
- Price
- $101
- Updated
- 2021/12/16
- Product number
- CS-W022612
- Product name
- Cinnolin-4(1H)-one
- Purity
- 98.48%
- Packaging
- 5g
- Price
- $121
- Updated
- 2021/12/16
- Product number
- FC139702
- Product name
- Cinnolin-4(1H)-one
- Packaging
- 500mg
- Price
- $140
- Updated
- 2021/12/16
1H-CINNOLIN-4-ONE Chemical Properties,Usage,Production
Synthesis Reference(s)
Synthesis, p. 288, 1987 DOI: 10.1055/s-1987-27921
Synthesis
551-93-9
18514-84-6
General procedure for the synthesis of 1H-cinnolin-4-one from o-aminoacetophenone: Preparation of Intermediate 1: 1,4-dihydro-4-quinolinone: An aqueous solution (10 mL) of sodium nitrite (4.0 g, 59 mmol) was slowly added dropwise over 20 min to a stirred mixture of 2-aminoacetophenone (5.0 g, 37.03 mmol) with concentrated hydrochloric acid (31 mL) under ice bath cooling conditions. The reaction mixture was continued to be stirred at the same temperature for 2 hours, then brought to room temperature and stirred overnight. After completion of the reaction, the mixture was concentrated under reduced pressure. The residue was neutralized with aqueous sodium acetate and then subjected to post-extraction treatment (ethyl acetate/brine) to give the final 1H-cinnolin-4-one (1.25 g, 23% yield). 1H-NMR (δ ppm, DMSO-d6, 300 MHz): 13.48 (br.s, 1H); 8.01 (d, J = 8.1 Hz, 1H); 7.82-7.73 (m, 2H); 7.57 (d, J = 8.1 Hz, 1H); 7.41 (t, J = 7.8 Hz, 1H).
References
[1] Heterocycles, 2008, vol. 75, # 1, p. 77 - 86
[2] Australian Journal of Chemistry, 1981, vol. 34, # 12, p. 2619 - 2627
[3] Patent: WO2009/53799, 2009, A1. Location in patent: Page/Page column 28-29
[4] Journal of the Chemical Society, 1947, p. 917,920
1H-CINNOLIN-4-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
1H-CINNOLIN-4-ONE Suppliers
- Tel
- --
- Fax
- --
- info@paragos.com
- Country
- Germany
- ProdList
- 6371
- Advantage
- 39
- Tel
- --
- Fax
- --
- info@activate-scientific.com
- Country
- Germany
- ProdList
- 2856
- Advantage
- 61