(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN

Product Name: (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
CAS No.: 1000578-26-6
Chemical Name: (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
Synonyms: AS 19;AS-19,AS19;(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN;(2S)-N,N-Dimethyl-5-(1,3,5-trimethyl-4-pyrazolyl)-1,2,3,4-tetrahydronaphthalen-2-amine;(S)-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine;2-Naphthalenamine, 1,2,3,4-tetrahydro-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-, (2S)-
CBNumber: CB5846829
Molecular Formula: C18H25N3
Formula Weight: 283.41
MOL File: Mol file

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(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Property

Boiling point:: 413.3±45.0 °C(Predicted)
Density: 1.09±0.1 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
solubility: <28.34mg/ml in ethanol; <28.34mg/ml in DMSO
form: oil
pka: 9.20±0.20(Predicted)
color: Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J64218
Product name: AS 19
Packaging: 10mg
Price: $243
Updated: 2021/12/16

Cayman Chemical

Product number: 20642
Product name: AS 19
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 20642
Product name: AS 19
Packaging: 10mg
Price: $249
Updated: 2024/03/01

Cayman Chemical

Product number: 20642
Product name: AS 19
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Tocris

Product number: 1968
Product name: AS 19
Purity: ≥98%(HPLC)
Packaging: 10
Price: $223
Updated: 2021/12/16

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(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Chemical Properties,Usage,Production

Uses

A potent 5-HT7 receptor agonist

Biological Activity

Reported potent 5-HT 7 receptor agonist (IC 50 = 0.83 nM). In vivo, enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia.

storage

Desiccate at -20°C

References

[1]. perez-garcía gs and meneses a. effects of the potential 5-ht7 receptor agonist as 19 in an autoshaping learning task. behav brain res, 2005, 163(1):136-40.
[2]. thomas dr and hagan jj. 5-ht7 receptors. current drug targets-cns & neurological disorders, 2004, 3(1): 81-90.
[3]. ulugol a, oltulu c, gunduz o, et al. 5-ht7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice. pharmacol biochem behav, 2012, 102(2):344-8.
[4]. león-ponte m, ahern gp and o'connell pj. serotonin provides an accessory signal to enhance t-cell activation by signaling through the 5-ht7 receptor. blood, 2007, 109(8):3139-46.
[5]. hoffman ms and mitchell gs. spinal 5-ht7 receptor activation induces long-lasting phrenic motor facilitation. j physiol, 2011, 589(pt 6):1397-407.

(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Suppliers

China 20 United Kingdom 1 United States 8 USA 1 Global 30

3B Pharmachem (Wuhan) International Co.,Ltd.

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1000578-26-6, (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALINRelated Search:

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(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN

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(S)-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine

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1000578-26-6

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Potent 5-HT7 receptor agonist.