(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
- Product Name
- (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
- CAS No.
- 1000578-26-6
- Chemical Name
- (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN
- Synonyms
- AS 19;AS-19,AS19;(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN;(2S)-N,N-Dimethyl-5-(1,3,5-trimethyl-4-pyrazolyl)-1,2,3,4-tetrahydronaphthalen-2-amine;(S)-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine;2-Naphthalenamine, 1,2,3,4-tetrahydro-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-, (2S)-
- CBNumber
- CB5846829
- Molecular Formula
- C18H25N3
- Formula Weight
- 283.41
- MOL File
- Mol file
(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Property
- Boiling point:
- 413.3±45.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- <28.34mg/ml in ethanol; <28.34mg/ml in DMSO
- form
- oil
- pka
- 9.20±0.20(Predicted)
- color
- Yellow
N-Bromosuccinimide Price
- Product number
- J64218
- Product name
- AS 19
- Packaging
- 10mg
- Price
- $243
- Updated
- 2021/12/16
- Product number
- 20642
- Product name
- AS 19
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 20642
- Product name
- AS 19
- Packaging
- 10mg
- Price
- $249
- Updated
- 2024/03/01
- Product number
- 20642
- Product name
- AS 19
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 1968
- Product name
- AS 19
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $223
- Updated
- 2021/12/16
(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Chemical Properties,Usage,Production
Uses
A potent 5-HT7 receptor agonist
Biological Activity
Reported potent 5-HT 7 receptor agonist (IC 50 = 0.83 nM). In vivo, enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia.
storage
Desiccate at -20°C
References
[1]. perez-garcía gs and meneses a. effects of the potential 5-ht7 receptor agonist as 19 in an autoshaping learning task. behav brain res, 2005, 163(1):136-40.
[2]. thomas dr and hagan jj. 5-ht7 receptors. current drug targets-cns & neurological disorders, 2004, 3(1): 81-90.
[3]. ulugol a, oltulu c, gunduz o, et al. 5-ht7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice. pharmacol biochem behav, 2012, 102(2):344-8.
[4]. león-ponte m, ahern gp and o'connell pj. serotonin provides an accessory signal to enhance t-cell activation by signaling through the 5-ht7 receptor. blood, 2007, 109(8):3139-46.
[5]. hoffman ms and mitchell gs. spinal 5-ht7 receptor activation induces long-lasting phrenic motor facilitation. j physiol, 2011, 589(pt 6):1397-407.