Sodium pentachlorophenolate Property

Melting point:

>300°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

Off-White to Pale Purple

CAS DataBase Reference

131-52-2(CAS DataBase Reference)

EPA Substance Registry System

Sodium pentachlorophenate (131-52-2)

Safety

Hazard Codes 

T+,N

Risk Statements 

24/25-26-36/37/38-40-50/53

Safety Statements 

1/2-22-36/37-45-61-60-52-28

RIDADR 

2567

RTECS 

SM6490000

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

29081990

Hazardous Substances Data

131-52-2(Hazardous Substances Data)

Toxicity

LD50 oral in rabbit: 328mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H330Fatal if inhaled

H335May cause respiratory irritation

H351Suspected of causing cancer

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P361Remove/Take off immediately all contaminated clothing.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

Sodium pentachlorophenolate Chemical Properties,Usage,Production

Description

Pentachlorophenol (PCP) can be found in two forms: pentachlorophenol itself or as the sodium salt of pentachlorophenol (NaPCP). These two forms have some different physical properties, but are expected to have similar toxic effects. PCP is a synthetic substance, made from other chemicals, and does not occur naturally in the environment. Although PCP was first synthesized in 1841, it was not produced commercially until 1936. It has since been registered for use as an insecticide, fungicide, herbicide, algicide, and disinfectant. By 1967, PCP and its sodium salt, NaPCP, were used extensively in industry and agriculture, due in large part to the solubility of PCP in organic solvents and of NaPCP in water. In 1977, both were listed together as the second most heavily used pesticide in the United States.

Chemical Properties

White or tan powder. Soluble in water, ethanol, and acetone; insoluble in benzene.

Chemical Properties

Sodium pentachlorophenate is a crystalline solid. Phenolic odor.

Uses

PCP and its water soluble salt, NaPCP, are commercially produced organochlorine compounds used primarily as the preservatives of wood and wood products, and secondarily as herbicides, insecticides, fungicides, molluscicides, and bactericides.

Uses

Fungicide; herbicide; slimicide; fermentation disinfectant, especially in finishes and papers.

General Description

Sodium pentachlorophenolate is a white or tan, powdered solid. Sodium pentachlorophenolate is soluble in water and may burn, but Sodium pentachlorophenolate is not easily ignited. Sodium pentachlorophenolate may be toxic by ingestion, inhalation and skin absorption. Sodium pentachlorophenolate is used as a fungicide, herbicide and as a disinfectant.

Air & Water Reactions

Soluble in water.

Reactivity Profile

Sodium pentachlorophenolate is incompatible with strong oxidizing agents.

Hazard

Toxic by ingestion, inhalation; skin irritant.

Health Hazard

Exposure can cause irritation of eyes, nose and throat. May cause weakness, excessive sweating, headache, dizziness, nausea, vomiting, and difficulty in breathing.

Fire Hazard

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as hydrogen chloride, polychlorodibenzodioxins and carbon monoxide, may be formed when involved in fire.

Safety Profile

Poison by ingestion, inhalation, skin contact, intravenous, intraperitoneal, subcutaneous, and intratracheal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland Na2O. See also CHLOROPHENOLS.

Potential Exposure

Uses include: wood preservative; as a fungicide in water-based latex paints; preservation of cellulose products, textiles, adhesives, leather, pulp, paper, and industrial waste systems; a contact and preemergence herbicide; general disinfectant and control of the intermediate snail host of schistosomiasis. The technical grade of sodium pentachlorophenate usually contain toxic microcontaminants including polychlorinated dibenzodioxins and dibenzofurans (132-64-9, and others).

Carcinogenicity

Data from a wide range and large number of studies evaluating the carcinogenic potential of pentachlorophenol are available. These include three longterm carcinogenicity studies in mice, three in rats, two studies evaluating the potential of pentachlorophenol to act as promoter in the carcinogenic process, and a “stop exposure” study. The results of the initiation and/or promotion studies are uniformly negative, as are the results of all the rat studies and two of the three long-term mouse studies. In addition, a very large body of genotoxicity evidence suggests that pentachlorophenol is nonmutagenic.

Environmental Fate

Routes and pathways, relevant physicochemical properties Solubility: in water 330 g l^-1 at 25 °C; soluble in ethanol, acetone; insoluble in benzene and petroleum oils. Partition behavior in water, sediment, and soil If released to air, NaPCP will exist solely in the aerosol phase in the ambient atmosphere. The aerosol phase will be removed from the atmosphere by wet and dry deposition. If released to soil and water under typical ambient conditions (pH 5–9), NaPCP is expected to exist predominately in its dissociated form (pKa 4.7). Releases to soil can decrease in concentration due to slow biodegradation (half-life is weeks to months) and leaching into groundwater. Releases to water may photolyze (half-life is hours to days with rate decreasing with depth of water), biodegrade, adsorb to sediments, or bioaccumulate in aquatic organisms. Biodegradation probably becomes significant after a period of acclimation.
Environmental persistency
NaPCP is not persistent in water, sewage, or soil because of bacterial decomposition. PCP readily decomposes in sunlight to monomeric and dimeric oxidation products in water. Principal decompose products are tetrachlororesorcinol, chloranilic acid, and dimeric products.
Bioaccumulation and biomagnification
Sodium pentachlorophenol did not appear to bioaccumulate in aquatic organisms to very high concentrations. BCFs for the compound were <1000 for most species tested.

Shipping

UN2567 Sodium pentachlorophenate, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Toxicity evaluation

The biochemical action of pentachlorophenol is active uncoupling of oxidation phosphorylation. PCP binds to mitochondrial protein and inhibits mitochondrial ATP-ase activity. Thus, both the formation of ATP and the release of energy to the cell from the breakdown of ATP to ADP are prevented. Electron transport is not inhibited by PCP, although reactions dependent on available high-energy bonds, such as oxidative and glycolytic phosphorylation, are affected. Binding to enzymatic protein has been reported and may lead to the inhibition of other cellular enzymes. There is also an increase in cellular oxygen demand during the uncoupling of oxidative phosphorylation. This causes the initial rise in respiration rate reported in individuals poisoned by PCP.

Incompatibilities

Uses include: wood preservative; as a fungicide in water-based latex paints; preservation of cellulose products, textiles, adhesives, leather, pulp, paper, and industrial waste systems; a contact and preemergence herbicide; general disinfectant and control of the intermediate snail host of schistosomiasis. The technical grade of sodium pentachlorophenate usually contain toxic microcontaminants including polychlorinated dibenzodioxins and dibenzofurans (132-64-9, and others).

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.