1，2-Dimethyl hydrazine Property

Melting point:

-8.9°C

Boiling point:

87.05°C

Density 

0.8274

refractive index 

1.4209

pka

9.29±0.70(Predicted)

Stability:

Stable. Incompatible with oxidizing agents, water, moisture.

IARC

2A (Vol. 4, Sup 7, 71) 1999

EPA Substance Registry System

1,2-Dimethylhydrazine (540-73-8)

Safety

Hazard Codes 

T,N

Risk Statements 

45-23/24/25-51/53

Safety Statements 

53-45-61

RIDADR 

2382

HazardClass 

6.1(a)

PackingGroup 

I

Hazardous Substances Data

540-73-8(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H350May cause cancer

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

1，2-Dimethyl hydrazine Chemical Properties,Usage,Production

Description

1,2-Dimethylhydrazine is a flammable, colorless, fuming liquid with a fishy, amine-like odor.Molecular weight= 60.12; Boiling point = 8081℃;Freezing/Melting point = 29℃; Flash point = # 23℃.Hazard Identification (based on NFPA-704 M RatingSystem): Health 3, Flammability 3, Reactivity 2. Solublein water

Chemical Properties

colourless or yellow hygroscopic liquid which fumes in air

Chemical Properties

1,2-Dimethylhydrazine is a colorless or yellow hygroscopic liquid and releases fumes in air. 1,2-Dimethylhydrazine is stable and incompatible with oxidizing agents, water, and moisture. Hydrazines include 1,1-dimethylhydrazine and 1,2-dimethylhydrazine, collectively. Hydrazines in pure form are clear, colorless liquids that quickly evaporate in air. Hydrazines smell somewhat like ammonia. Hydrazines are highly reactive and easily catch fi re. 1,1-Dimethylhydrazine, and 1,2-dimethylhydrazine are somewhat similar in chemical structure and reactivity. However, there are some clear differences in their production, uses, and adverse health effects. There are many other hydrazine compounds. Hydrazines are manufactured from chemicals such as ammonia, dimethylamine, hydrogen perox- ide, and sodium hypochlorite. A small amount of hydrazine occurs naturally in some plants. Large amounts of hydrazines are in different countries. 1,2-Dimethylhydrazine is a research chemical and the quantities produced are likely to be much less. Hydrazine has been used as a fuel source for rocket propellant and spacecraft, including the space shuttle. Hydrazine is also used to treat boiler water to reduce corrosion and to reduce other chemical substances. Hydrazine is used as a medicine and in the manufacture of other medicines, farm chemicals, and plastic foams. 1,1-Dimethylhydrazine has been used as a rocket propellant and in the manufacture of other chemical substances, while the literature indicate that 1,2-dimethylhydrazine has no commercial use but is used in researches to study colon cancer in experimental animals.

Uses

1,2-Dimethylhydrazine (SDMH) unlike its analog 1,1- dimethylhydrazine (UDMH) is used only in small quantities as a research chemical. There are no known commercial uses, although it was evaluated as a high-energy rocket fuel. The material is a fuming, strongly alkaline, moderately volatile liquid.

Definition

ChEBI: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.

General Description

A colorless liquid with an ammonia-like odor. Less dense than water. Flash point is 5°F. Contact irritate skin, eyes, and mucous membranes. Very toxic by ingestion, inhalation and skin absorption. Used to make photographic chemicals.

Air & Water Reactions

Highly flammable. Fumes upon exposure to air . Soluble in water with evolution of heat.

Reactivity Profile

1，2-Dimethyl hydrazine dissolves, swells, and disintegrates many plastics [USCG, 1999].

Health Hazard

Breathing of vapor causes pulmonary irritation, delayed gastro-intestinal irritation, tremors, and convulsions. Contact with skin or mucous membranes causes chemical burns. Can be absorbed through skin to cause systemic intoxication and convulsions.

Health Hazard

Inhalation exposure to hydrazines, cause adverse health effects and poisoning to animals and humans. The symptoms of toxicity and poisoning include, but are not limited to, injury to the lungs, liver, kidney, vomiting, uncontrolled shaking, lethargy (sluggishness), coma, and neuritis (an infl ammation of the nerves), convulsions, tremors, seizures, and the CNS. Effects on the nervous system have also been seen in animals exposed to hydrazine and 1,1-dimethylhydrazine, but not to 1,2-dimethylhydrazine.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, intraperitoneal, intravenous, subcutaneous, and intramuscular routes. Moderately toxic by inhalation. Human mutation data reported. A very dangerous fire hazard when exposedto heat, flame, or oxidizers. A hgh-energy propellant for liquid-fueled rockets. When heated to decomposition it emits toxic fumes of NOx

Potential Exposure

1,2-Dimethylhydrazine is an experimental rocket fuel and is used in chemical synthesis; a laboratory chemical. Mutagen

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water ormilk. Do not induce vomiting

Carcinogenicity

SDMH is carcinogenic to mice, rats, and hamsters using a variety of exposure routes. Oral doses of 21 mg/kg for 11 weeks produced intestinal tumors in rats. A lower dose (3 mg/kg) in drinking water for 12 months produced liver hemangioendotheliomas.A number of these tumors were metastatic. Mice given doses of 60–90 mg/day in drinking water developed a variety of tumors including angiosarcomas and lung adenomas . Both oral administration and intraperitoneal injection increased lung adenomas in the A/J strain mouse. Hamsters also developed angiosarcomas, intestinal tumors, and liver tumors following average daily intakes of 160 mg in drinking water. An in-depth description of the uniqueness of the colonic tumors was presented.

storage

(1) Color Code—Red: Flammability Hazard: Storein a flammable liquid storage area or approved cabinetaway from ignition sources and corrosive and reactivematerials. (2) Color Code—Yellow Stripe (strong reducingagent): Reactivity Hazard; Store separately in an area isolated from flammables, combustibles, or other yellow-codedmaterials. (3) Color Code—Blue: Health Hazard/Poison(mutagen): Store in a secure poison location. Prior to working with SDMH you should be trained on its proper handling and storage. Store in tightly closed containers

Shipping

This compound requires a shipping label of“POISONOUS/TOXIC MATERIALS, FLAMMABLELIQUID.” It falls in Hazard Class 6.1 and Packing Group I.

Incompatibilities

Forms explosive mixture with air. Astrong reducing agent and strong base. Violent reactionwith strong oxidizers, strong acids, metallic oxides. Attackssome plastics, rubber, and coatings. May accumulate staticelectrical charges, and may cause ignition of its vapors.