4-Aminoantipyrine

Product Name: 4-Aminoantipyrine
CAS No.: 83-07-8
Chemical Name: 4-Aminoantipyrine
Synonyms: 4-AAP;AMPYRONE;AMINOANTIPYRINE;4-AMINOPHENAZONE;4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one;4-AMINOANTIPYRIN;4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE;4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE;NSC 60242;Minoazophene
CBNumber: CB7485059
Molecular Formula: C11H13N3O
Formula Weight: 203.24
MOL File: 83-07-8.mol

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4-Aminoantipyrine Property

Melting point:: 105-110 °C(lit.)
Boiling point:: 340 C
Density: 0.8
refractive index: 1.4930 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: H₂O: 0.1 g/mL, clear
pka: pK1: 4.94(+1) (25°C)
form: Powder or Crystals
color: Yellow to yellow-brown
PH: 7.1 (100g/l, H2O, 20℃)(slurry)
Odor: Odorless
Water Solubility: ca. 500 g/L (20 ºC)
Merck: 14,591
BRN: 181635
Stability:: Stable. May be light sensitive.
LogP: -0.257 (est)
CAS DataBase Reference: 83-07-8(CAS DataBase Reference)
NIST Chemistry Reference: Aminoantipyrene(83-07-8)
EPA Substance Registry System: 4-Aminoantipyrene (83-07-8)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36-36/37/39
WGK Germany: 3
RTECS: CD2480000
F: 8-9-23
Hazard Note: Harmful
TSCA: Yes
HS Code: 29331190
Toxicity: LD50 orally in Rabbit: 1700 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 33528
Product name: 4-Aminoantipyrine
Purity: puriss. p.a., reag. Ph. Eur., ≥99%
Packaging: 25g
Price: $92.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 33528
Product name: 4-Aminoantipyrine
Purity: puriss. p.a., reag. Ph. Eur., ≥99%
Packaging: 100g
Price: $99.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1.07293
Product name: 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
Purity: GR for analysis
Packaging: 10g
Price: $108
Updated: 2024/03/01

Sigma-Aldrich

Product number: 06800
Product name: 4-Aminoantipyrine
Purity: for spectrophotometric det. of H2O2 and phenols, ≥98.0%
Packaging: 25g
Price: $46.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1.07293
Product name: 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
Purity: GR for analysis
Packaging: 100g
Price: $406
Updated: 2024/03/01

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4-Aminoantipyrine Chemical Properties,Usage,Production

Chemical Properties

Amber crystalline powder

Uses

4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties. It readily forms metal complexes due to its amino nitrogen, a strong coordination site.
4-aminoantipyrine forms Schiff bases when treated with aldehydes/ketones, which are used in chemosensing applications.
Coupling Reagent for Trinder's reagent in colorimetric hydrogen peroxide detectionassays.
Forms highly stable dyes by coupling with Trinder's reagent in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.

Application

4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is also used as indicator for trace phenol determinations in water.
Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample.

Definition

ChEBI: 4-aminoantipyrine is a pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antipyretic, a drug metabolite and a marine xenobiotic metabolite. It is a primary amino compound and a pyrazolone. It derives from an antipyrine.

Preparation

synthesis of 4-aminoantipyrine: Antipyrine is nitrosated by sodium nitrite, reduced by ammonium bisulfite and ammonium sulfite, hydrolyzed by sulfuric acid, and finally neutralized with liquid ammonia to obtain 4-aminoantipyrine.

General Description

4-Aminoantipyrine forms heterocyclic Schiff bases, by reaction with various aldehydes and oximes. These Schiff bases form stable complexes with transition metals.

Purification Methods

It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.]

4-Aminoantipyrine Preparation Products And Raw materials

Raw materials

Ammonium bisulfite Iodine solution Sodium nitrite Antipyrine Starch paper Sulfuric acid

Preparation Products

Aminopyrine N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)formamide 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one AMMONIUM ALGINATE

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4-Aminoantipyrine Suppliers

Americas 1 Austria 1 Belgium 1 Canada 2 China 273 Czech Republic 1 Europe 3 France 2 Germany 9 India 30 Japan 5 Switzerland 2 Ukraine 1 United Kingdom 16 United States 52 Global 399

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 18521732826;
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Hubei jian chu biological technology co., LTD

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Shenyang yimoke chemical products co. LTD

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Hangzhou Bingochem Co., Ltd.

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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INTATRADE GmbH

Tel: +49 3493/605464
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Email: sales@intatrade.de
Country: Germany
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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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BeiJing Hwrk Chemicals Limted

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View Lastest Price from 4-Aminoantipyrine manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: 4-Aminoantipyrine 83-07-8
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000
Release date: 2024-03-25

Hebei Mojin Biotechnology Co., Ltd

Product: 4-Aminoantipyrine 83-07-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-11-30

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Aminoantipyrine 83-07-8
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98.0%
Supply Ability: 10kg/month
Release date: 2021-07-23

83-07-8, 4-AminoantipyrineRelated Search:

Cefazolin sodium salt Cefazolin Chlorodimethylphenylsilane Dimethyl ether Dimethyl fumarate Dimethyl carbonate N,N-Dimethyl-1,4-phenylenediamine Antipyrine Dimethyl sebacate Dimethyl sulfoxide Propyphenazone 4,4'-Diaminodiphenylsulfone N,N-Dimethylformamide Acetaminophen Glucosamine 3,4'-DIAMINODIPHENYLMETHANE DIANTIPYRYLMETHANE EC 2.6.1.2

Metamizole EP Impurity B

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

Metamizole Sodium Impurity 2（Minocycline EP Impurity B）

4-aminoantipirine

4-Amine-2,3-dimethyl-lphenyl-5-pyrazolone-[5],Ampyrone

4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on

AKOS BBS-00007964

AMINOANTIPYRINE

AMINOANTIPYRINE, 4-

AMINOANTIPYRINE REAGENT

AMINOPHENYZONE

AMPYRONE

1-PHENYL-2,3-DIMETHYL-4-AMINOPYRAZOLONE

1,5-DIMETHYL-2-PHENYL-4-AMINOPYRAZOLONE

4-AMINOPHENAZONE

4-AMINOANTIPYRENE

4-AMINOANTIPYRIN

4-AMINOANTIPYRINE

4-AMINOANTIPYRINE REAGENT

4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE

4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLINE-5-ONE

4-AMINO-1,3-DIMETHYL-2-PHENYL-3-PYRAZOLONE

4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE

4-AMINO-1,5-DIMETHYL-2-PHENYL-3H-PYRAZOL-3-ONE

4-Amino-1,5-dimethyl-2-phenyl-3-pyrazolone

1,5-dimethyl-2-phenyl-4-aminopyrazolin

4-AMINOANTIPYRINE [4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE]

4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Ampyrone

1,2-Dihydro-1,5-dimethyl-2-phenyl-4-amino-3H-pyrazol-3-one

1-Phenyl-2,3-dimethyl-4-amino-5-pyrazolone

4-Amino-2,3-dimethyl-1-phenyl-5-pyrazolone

4-Aminoantipyrine [for Biochemical Research]

4-Aminoantipyrine,98%

4-Aminoantipyrine;4-aminophenazone

4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYR-AZOL IN-5-ON R. G., REAG. PH. EUR. I

4-AMINOANTIPYRINE FREE BASE

4-AminoantipyrinePuriss

4-AminoantipyrinePuriss(4-Aminophenazone)

4-AMINOBENZENE SULFONIC ACID( Sulphanilic Acid)

4-Amino-1,5-dimethyl-2-phenyl-4-pyrazolin-3-one

Aminoantipyrene

4-amino antipyirine

4-AMINOANTIPYRIDINE (AMPYRONE)

AMINOANTIPYRINE, 4-(RG)

4-Aminoantipyrine,4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Ampyrone

4-Aminoantipyrine p.a.

AMINOANTIPYRINE, 4-(AMPYRONE)(RG)

4-AMINOANTIPYRINERESEARCH GRADE

1,5-Dimethyl-2-phenyl-4-aminopyrazoline

1-Phenyl-2,3-dimethyl-4-aminopyrazloone-[5]

3H-Pyrazol-3-one, 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-

3-Pyrazolin-5-one, 4-amino-2,3-dimethyl-1-phenyl-

4-AAP

4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, 4-Aminophenazone

(2,3-Dihydro-1,5-diMethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)aMine

Minoazophene

NSC 60242

(2,3-Dihydro-1,5-(diMethyl-d3)-3-oxo-2-phenyl-1H-pyrazol- 4-yl)aMine