4-Aminoantipyrine
- Product Name
- 4-Aminoantipyrine
- CAS No.
- 83-07-8
- Chemical Name
- 4-Aminoantipyrine
- Synonyms
- 4-AAP;AMPYRONE;AMINOANTIPYRINE;4-AMINOPHENAZONE;4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one;4-AMINOANTIPYRIN;4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE;4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE;NSC 60242;Minoazophene
- CBNumber
- CB7485059
- Molecular Formula
- C11H13N3O
- Formula Weight
- 203.24
- MOL File
- 83-07-8.mol
4-Aminoantipyrine Property
- Melting point:
- 105-110 °C(lit.)
- Boiling point:
- 340 C
- Density
- 0.8
- refractive index
- 1.4930 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- H2O: 0.1 g/mL, clear
- pka
- pK1: 4.94(+1) (25°C)
- form
- Powder or Crystals
- color
- Yellow to yellow-brown
- PH
- 7.1 (100g/l, H2O, 20℃)(slurry)
- Odor
- Odorless
- Water Solubility
- ca. 500 g/L (20 ºC)
- Merck
- 14,591
- BRN
- 181635
- Stability:
- Stable. May be light sensitive.
- LogP
- -0.257 (est)
- CAS DataBase Reference
- 83-07-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Aminoantipyrene(83-07-8)
- EPA Substance Registry System
- 4-Aminoantipyrene (83-07-8)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39
- WGK Germany
- 3
- RTECS
- CD2480000
- F
- 8-9-23
- Hazard Note
- Harmful
- TSCA
- Yes
- HS Code
- 29331190
- Toxicity
- LD50 orally in Rabbit: 1700 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 33528
- Product name
- 4-Aminoantipyrine
- Purity
- puriss. p.a., reag. Ph. Eur., ≥99%
- Packaging
- 25g
- Price
- $92.5
- Updated
- 2024/03/01
- Product number
- 33528
- Product name
- 4-Aminoantipyrine
- Purity
- puriss. p.a., reag. Ph. Eur., ≥99%
- Packaging
- 100g
- Price
- $99.2
- Updated
- 2024/03/01
- Product number
- 1.07293
- Product name
- 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
- Purity
- GR for analysis
- Packaging
- 10g
- Price
- $108
- Updated
- 2024/03/01
- Product number
- 06800
- Product name
- 4-Aminoantipyrine
- Purity
- for spectrophotometric det. of H2O2 and phenols, ≥98.0%
- Packaging
- 25g
- Price
- $46.1
- Updated
- 2024/03/01
- Product number
- 1.07293
- Product name
- 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
- Purity
- GR for analysis
- Packaging
- 100g
- Price
- $406
- Updated
- 2024/03/01
4-Aminoantipyrine Chemical Properties,Usage,Production
Chemical Properties
Amber crystalline powder
Uses
4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties. It readily forms metal complexes due to its amino nitrogen, a strong coordination site.
4-aminoantipyrine forms Schiff bases when treated with aldehydes/ketones, which are used in chemosensing applications.
Coupling Reagent for Trinder's reagent in colorimetric hydrogen peroxide detectionassays.
Forms highly stable dyes by coupling with Trinder's reagent in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.
Application
4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is also used as indicator for trace phenol determinations in water.
Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample.
Definition
ChEBI: 4-aminoantipyrine is a pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antipyretic, a drug metabolite and a marine xenobiotic metabolite. It is a primary amino compound and a pyrazolone. It derives from an antipyrine.
Preparation
synthesis of 4-aminoantipyrine: Antipyrine is nitrosated by sodium nitrite, reduced by ammonium bisulfite and ammonium sulfite, hydrolyzed by sulfuric acid, and finally neutralized with liquid ammonia to obtain 4-aminoantipyrine.
General Description
4-Aminoantipyrine forms heterocyclic Schiff bases, by reaction with various aldehydes and oximes. These Schiff bases form stable complexes with transition metals.
Purification Methods
It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.]
4-Aminoantipyrine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Aminoantipyrine manufacturers
- Product
- 4-Aminoantipyrine 83-07-8
- Price
- US $60.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000
- Release date
- 2024-03-25
- Product
- 4-Aminoantipyrine 83-07-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-11-30
- Product
- 4-Aminoantipyrine 83-07-8
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98.0%
- Supply Ability
- 10kg/month
- Release date
- 2021-07-23