Product features Chemical Properties Uses Production method Category Toxicity grading Acute toxicity Irritation data Flammable and hazardous characteristics Storage characteristics Extinguishing agent
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Chloroacetonitrile

Product features Chemical Properties Uses Production method Category Toxicity grading Acute toxicity Irritation data Flammable and hazardous characteristics Storage characteristics Extinguishing agent
Product Name
Chloroacetonitrile
CAS No.
107-14-2
Chemical Name
Chloroacetonitrile
Synonyms
CH2ClCN;usafkf-5;USAF kf-5;oroacetonitriL;Chloracetonitrile;AKOS BBS-00004385;Chlorocyanomethane;chloro-acetonitril;CHLOROACETONITRILE;CHLOROETHANENITRILE
CBNumber
CB5852703
Molecular Formula
C2H2ClN
Formula Weight
75.5
MOL File
107-14-2.mol
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Chloroacetonitrile Property

Melting point:
38℃
Boiling point:
124-126 °C (lit.)
Density 
1.193 g/mL at 25 °C (lit.)
vapor density 
3 (vs air)
vapor pressure 
1.78 psi ( 20 °C)
refractive index 
n20/D 1.422(lit.)
Flash point:
118 °F
storage temp. 
2-8°C
form 
Liquid
color 
Clear colorless
Water Solubility 
INSOLUBLE
BRN 
506028
Stability:
Stable, but reacts with water. Combustible. Incompatible with water, moisture, strong oxidizing agents, acids.
InChIKey
RENMDAKOXSCIGH-UHFFFAOYSA-N
CAS DataBase Reference
107-14-2(CAS DataBase Reference)
IARC
3 (Vol. 52, 71) 1999
NIST Chemistry Reference
Acetonitrile, chloro-(107-14-2)
EPA Substance Registry System
Chloroacetonitrile (107-14-2)
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Safety

Hazard Codes 
T,N
Risk Statements 
23/24/25-51/53
Safety Statements 
45-61
RIDADR 
UN 2668 6.1/PG 2
WGK Germany 
3
RTECS 
AL8225000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29269095
Hazardous Substances Data
107-14-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C19651
Product name
Chloroacetonitrile
Purity
99%
Packaging
5g
Price
$25.4
Updated
2021/03/22
Sigma-Aldrich
Product number
C19651
Product name
Chloroacetonitrile
Purity
99%
Packaging
100g
Price
$46.1
Updated
2021/03/22
Alfa Aesar
Product number
A12825
Product name
Chloroacetonitrile, 98+%
Packaging
100g
Price
$26.6
Updated
2021/03/22
Alfa Aesar
Product number
A12825
Product name
Chloroacetonitrile, 98+%
Packaging
1kg
Price
$155
Updated
2021/03/22
Sigma-Aldrich
Product number
C19651
Product name
Chloroacetonitrile
Purity
99%
Packaging
500g
Price
$135
Updated
2021/03/22
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Chloroacetonitrile Chemical Properties,Usage,Production

Product features

Chloroacetonitrile, also known as "cyanide chloromethane" has its chemical formula being ClCH2CN and the molecular weight being 75.50. It is colorless and fuming liquid with the melting point being 38 ℃ and boiling point being 126~127 ℃ (decomposition), 30~32 ℃ (2.0kPa), the relative density being 1.1930 and the refractive index being 1.420225. It is soluble in ether, alcohol and hydrocarbons but insoluble in water. It is highly toxic. It can form adduct with aluminum trichloride and react with various kinds of reagents including phloroglucinol trimethylether, methoxyacetophenone, Grignard reagent and anhydrous hydrogen chloride. It can be obtained through the dehydration of chloroacetamide under the action of phosphorus pentoxide, or the reaction between excess amount of acetonitrile with chlorine at 460 ℃ as well as introducing ammonia gas into the ether solution of dichloro acetylene. Chloroacetonitrile can be used as a fumigant.
Fumigants refer to a kind of pesticides whose volatile vapor can be applied to poison and kill pests. Its gaseous molecules can enter into the body of the harmful organisms and exert toxic effects. It can also exist in forms being different from gas such as liquid, solid or compressed gaseous form. The usage dose can be calculated according to the volume of space fumigation place (unit: g/m 3). The applied concentration can be based on the fumigation period, the closeness extent of fumigation place and the amount of material as well as its absorption capability of fumigant vapor. It is suitable to be used in the closed or nearly closed conditions in places such as warehouse, tent, house, car, etc. In the case of large concentration of the object to be fumigated, it can effectively eliminate hidden pests or pathogens.
The fumigant vapor generally directly enters into the respiratory system through the skin or valve of the pests, thus penetrating into blood and cause the poisoning and death of pests. Its insecticidal effect is generally believed to be located in the chemical action on the enzyme. For example, methyl bromide can combine with thiol, causing gradually reversible or irreversible inhibitory effects on various kinds of enzymes inside the pest body. Phosphine can cause inhibition on the animal central nervous system, irritate the lungs and cause edema, resulting in swelling heart syndrome. Fumigants such as trichloroethane, dibromoethane and carbon tetrachloride are mainly narcotics while carbon dioxide mainly causes stifling effect.
This information is edited by Xiongfeng Dai from Chemicalbook.

Chemical Properties

It is colorless, transparent fuming liquid with a pungent choking smell. It is soluble in alcohol and ether.

Uses

1. It can be used as raw material of organic synthesis and analytical reagents.
2. It can be used as pharmaceutical intermediates, pesticides.

Production method

It can be obtained through: chloroacetic acid is reacted with ethanol to generate ethyl chloroacetate, which then generate chloroacetamide through reaction with ammonia; finally have dehydration to get it. Detailed process: add trichloroacetic acid to the ethanol; add under stirring of concentrated sulfuric acid; the stirring was stopped after heating reflux; have the reaction for 8-10 h, filter and wash with water, separate out the water layer to obtain ethyl chloroacetate. Add it to the ammonia of 0-2 ℃ with the temperature being not exceed 15 ℃; sir for 10 to 15 mins after finishing adding added, cool, stand, filtrate and dry to obtain the chloroacetamide. Then, to the chloroacetamide, add phosphorus pentoxide and perform thermal dehydration with heating and distilling chloroacetonitrile out simultaneously; finally perform distillation under reduced pressure to evaporate out all the chloroacetonitrile. The resulting crude product is hydrated using phosphorus pentoxide and magnesium sulfate with vacuum distillation to derive the finished products.

Category

Toxic substances.

Toxicity grading

Highly toxic.

Acute toxicity

Oral-rat LD50: 220 mg/kg; Oral-Mouse LD50: 139 mg/kg.

Irritation data

Skin-Rabbit 14 mg/24 hr mild; Eye-Rabbit 20 mg/24 hours of moderate.

Flammable and hazardous characteristics

Combustible upon fire with thermal decomposition into toxic nitrogen compounds, chloride and cyanide gas.

Storage characteristics

Treasury: ventilated and low-temperature and dry; store it separately from oxidants, acids and food additives.

Extinguishing agent

Dry powder, carbon dioxide and sand. pH extinguishing agent should be disabled.

Chemical Properties

colourless liquid

Chemical Properties

A clear, colorless liquid. Pungent odor.

Uses

Fumigant, intermediate.

Preparation

In a 3-L round-bottomed, threenecked flask fitted with an efficient mechanical stirrer, a reflux condenser, and a thermometer were placed phosphorus pentoxide (170 g, 1.2 mol), chloroacetamide 1423 (187 g, 2 mol), and dry technical grade trimethylbenzene (800 mL). The mixture was gently refluxed with vigorous stirring for 1 h. It was then allowed to cool to about 100 C° with continuous stirring, and the reflux condenser was replaced with a distillation head fitted with a thermometer and a water-cooled condenser. The crude product and part of the solvent were distilled at atmospheric pressure. The yield of crude product boiling at 124–128 C° was 121–131 g (80–87%). In order to obtain a pure product, the crude chloroacetonitrile was mixed with phosphorus pentoxide (10 g) and redistilled through an efficient packed fractionating column. The yield of pure chloroacetonitrile distilling at 123–124 C° was 93–106 g (62–70%).

General Description

A colorless liquid with a pungent odor. Flash point 118°F. Insoluble in water and denser than water. Hence, sinks in water. Very toxic by ingestion, inhalation and skin absorption. A lachrymator. Used to make other chemicals and as a fumigant.

Air & Water Reactions

Flammable. Insoluble in water and denser than water. Hence, sinks in water. Reacts with water and steam to produce toxic vapors of hydrogen chloride.

Reactivity Profile

Chloroacetonitrile reacts with water, steam, strong acids or acid fumes to produce toxic vapors of hydrogen chloride. When heated to decomposition, Chloroacetonitrile emits highly toxic fumes of hydrogen cyanide and hydrogen chloride [Sax, 2nd ed., 1963, p. 600].

Hazard

Irritant. Questionable carcinogen.

Health Hazard

TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Poison by ingestion, skin contact, and intraperitoneal routes. Moderately toxic by inhalation. A skin irritant. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. Flammable liquid. See also NITRILES. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and CN-.

Potential Exposure

A chlorinated haloacetonitrile used as a fumigant and as a manufacturing chemical intermediate for making other chemicals

Shipping

UN2668 Chloroaceto nitrile Hazard class: 6.1, Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid Inhalation Hazard Zone B.

Purification Methods

Reflux it with P2O5 for one day, then distil it through a helices-packed column. Also purified by gas chromatography. [Beilstein 2 IV 492.] LACHRYMATOR, HIGHLY TOXIC.

Incompatibilities

Highly flammable, forms explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Reacts with water and steam, releasing toxic and corrosive vapors of hydrogen chloride. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously low aqueous solubility. They are also insoluble in aqueous acids. with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

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Chloroacetonitrile Suppliers

Shanghai Kaisai Chemical Co., Ltd
Tel
021-33516711;021-33516722
Fax
021-33516776
Email
kaisaichem1@163.com;kaisaichem1@163.com
Country
China
ProdList
4719
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820-
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1401
Advantage
62
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43494
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028-
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12356
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078;021-50426030
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
10006
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100-
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9639
Advantage
66
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View Lastest Price from Chloroacetonitrile manufacturers

Shanghai Rlavie Technology Co ltd
Product
Chloroacetonitrile 107-14-2
Price
US $0.00/KG
Min. Order
1g
Purity
99%minGC
Supply Ability
20Tons/month
Release date
2021-07-11
YANGZHOU SHUANGDING CHEM CO., LTD
Product
Chloroacetonitrile 107-14-2
Price
US $0.00/Kg/Drum
Min. Order
200KG
Purity
99%
Supply Ability
300 tons/year
Release date
2020-07-29
Longyan Tianhua Biological Technology Co., Ltd
Product
Chloroacetonitrile 107-14-2
Price
US $5.00/Kg/Bag
Min. Order
25Kg/Bag
Purity
99%
Supply Ability
20Tons
Release date
2020-11-11

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