Tipelukast

Product Name: Tipelukast
CAS No.: 125961-82-2
Chemical Name: Tipelukast
Synonyms: KCA 757;tipelukast;MN-001 (Tipelukast);MN 001 (pharMaceutical);Butanoic acid, 4-[6-acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)thio]propoxy]-2-propylphenoxy]-;4-[6-acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)sulfanyl]propoxy]-2-propylphenoxy]butanoic acid
CBNumber: CB5855229
Molecular Formula: C29H38O7S
Formula Weight: 530.67282
MOL File: 125961-82-2.mol

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Tipelukast Property

Melting point:: 82-84°C
Boiling point:: 735.3±60.0 °C(Predicted)
Density: 1.22
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
pka: 4.59±0.10(Predicted)
form: Solid
color: Off-White to Pale Beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11948
Product name: MN-001
Purity: ≥98%
Packaging: 500μg
Price: $71
Updated: 2024/03/01

Cayman Chemical

Product number: 11948
Product name: MN-001
Purity: ≥98%
Packaging: 1mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 11948
Product name: MN-001
Purity: ≥98%
Packaging: 5mg
Price: $458
Updated: 2024/03/01

TRC

Product number: T444870
Product name: Tipelukast
Packaging: 25mg
Price: $1620
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA76242
Product name: Tipelukast
Packaging: 25mg
Price: $2015
Updated: 2021/12/16

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Tipelukast Chemical Properties,Usage,Production

Uses

Tipelukast a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model.

Definition

ChEBI: Tipelukast is an aromatic ketone.

Biological Activity

Tipelukast is a Leukotriene D4 (LTD4) receptor antagonist and an inhibitor of 5-lipoxygenase (5-LO) and also phosphodiesterases PDE3 and PDE4. It has been found to have antifibrotic and anti-inflammatory activity. Tipelukast has been investigated as a possible treatment for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).

in vivo

Fiftheen min after an aerosolized antigen challenge, and UNDW inhaled 5 min later into the guinea pigs, Tipelukast significantly alters the UNDW-induced bronchoconstriction^[1]. Tipelukast (1 and 5 mg/kg) administered intravenously 15 min after antigen challenge reduces the propranolol-induced bronchoconstriction (PIB) in a dose-dependent manner in guinea-pigs^[2].

IC 50

LTD₄: 6.41 (pA2, In guinea-pigs); LTE₄: 6.45 (pA2, In guinea-pigs)

Tipelukast Preparation Products And Raw materials

Raw materials

Preparation Products

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Tipelukast Suppliers

China 14 France 1 India 2 United Kingdom 1 United States 7 Global 25

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

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tipelukast

KCA 757

MN 001 (pharMaceutical)

MN-001 (Tipelukast)

4-[6-acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)sulfanyl]propoxy]-2-propylphenoxy]butanoic acid

Butanoic acid, 4-[6-acetyl-3-[3-[(4-acetyl-3-hydroxy-2-propylphenyl)thio]propoxy]-2-propylphenoxy]-

125961-82-2

125961-82-1

C29H38O7S