ChemicalBook > CAS DataBase List > 4-Phenylbutyric acid

4-Phenylbutyric acid

Product Name
4-Phenylbutyric acid
CAS No.
1821-12-1
Chemical Name
4-Phenylbutyric acid
Synonyms
4-PHENYLBUTANOIC ACID;PHENYLBUTYRIC ACID;Benzenebutanoic acid;Buphenyl;PHENYLBUTYRIC-4 ACID;NSC 295;4-benzene acid;AKOS BBS-00003749;Benzenebutyric acid;benzenebutanoicacid
CBNumber
CB2385237
Molecular Formula
C10H12O2
Formula Weight
164.2
MOL File
1821-12-1.mol
More
Less

4-Phenylbutyric acid Property

Melting point:
49-51 °C(lit.)
Boiling point:
165 °C10 mm Hg(lit.)
Density 
1.0326 (rough estimate)
refractive index 
1.5405 (estimate)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
5.3g/l. Almost insoluble in water, soluble in alcohol and oils
form 
Crystalline Powder
pka
4.76(at 25℃)
color 
White to slightly yellow
Water Solubility 
5.3 g/L at 40 ºC
BRN 
638180
InChIKey
OBKXEAXTFZPCHS-UHFFFAOYSA-N
LogP
2.420
CAS DataBase Reference
1821-12-1(CAS DataBase Reference)
NIST Chemistry Reference
4-Phenylbutanoic acid(1821-12-1)
EPA Substance Registry System
4-Phenylbutyric acid (1821-12-1)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29163900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P21005
Product name
4-Phenylbutyric acid
Purity
99%
Packaging
25g
Price
$66.1
Updated
2024/03/01
Sigma-Aldrich
Product number
P21005
Product name
4-Phenylbutyric acid
Purity
99%
Packaging
100g
Price
$161
Updated
2024/03/01
TCI Chemical
Product number
P0643
Product name
4-Phenylbutyric Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$56
Updated
2024/03/01
TCI Chemical
Product number
P0643
Product name
4-Phenylbutyric Acid
Purity
>98.0%(GC)(T)
Packaging
250g
Price
$297
Updated
2024/03/01
Alfa Aesar
Product number
A18115
Product name
4-Phenylbutyric acid, 99%
Packaging
25g
Price
$54.65
Updated
2024/03/01
More
Less

4-Phenylbutyric acid Chemical Properties,Usage,Production

Chemical Properties

4-Phenylbutyric acid is white to slightly yellowish crystalline powder. It is slightly soluble in chloroform and methanol. Its solubility in water is 5.3 g/l (at 40 °C).

Uses

4-Phenylbutyric acid is used as a chemical chaperone involved in protein-folding disorders. It is involved in the synthesis of dyes and an active pharmaceutical ingredient intermediate.

Preparation

4-phenylbutyric acid is obtained by the reaction of benzene with butyrolactone in the presence of aluminum chloride, followed by neutralization with base.
Synthesis of 4-phenylbutyric acid

Application

4-Phenylbutyric acid (4-PBA) is used in the treatment of urea cycle disorders under the trade name Buphenyl. 4-PBA has been used as a selective inhibitor of endoplasmic reticulum stress (ERS).
4-Phenylbutyric acid is used as organic intermediates. It can also be used as a reactant in the synthesis of:
1-Tetralone using Lewis acid catalyst.
4,N-diphenylbutyramide.

Definition

4-Phenylbutyric acid is a monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apopto is in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 3309, 1991 DOI: 10.1016/S0040-4039(00)92693-5

General Description

4-Phenylbutyric acid (4-PBA) is a small-molecular-weight fatty acid with a terminal aromatic group, and its sodium salt (sodium 4-phenyl butyrate) has been used for the treatment of urea cycle disorders. This molecule is also used for the treatment of sickle cell diseases and thalassemia owing to its ability to activate β-globin transcription. Moreover, 4-PBA is employed as an orally bioavailable agent for the treatment of spinal muscular atrophy (SMA) and tumors.
Neuroprotective Effects of 4-phenylbutyric Acid and Its Derivatives: Possible Therapeutics for Neurodegenerative Diseases

Purification Methods

Crystallise the acid from pet ether (b 40-60o). [Beilstein 9 IV 1811.]

More
Less

4-Phenylbutyric acid Suppliers

Nanjing Weiyuan Biomedical Co., Ltd.
Tel
17312961000
Email
syrz2020@gamil.com
Country
China
ProdList
35
Advantage
58
Nantong Xiaochang Pharmaceutical Trading Co., Ltd.
Tel
0513-82104991 18068193575
Fax
QQ1907456386
Email
sales2@btcpharm.com
Country
China
ProdList
1332
Advantage
58
Zhejiang zetian fine chemical co. LTD
Tel
0571-87322520 18957127338
Fax
QQ:800182836
Email
sales@zetchem.com
Country
China
ProdList
451
Advantage
58
LEWOO PHARMATECH (SHANGHAI) CO.,LTD
Tel
15800805830
Fax
021 67898603
Email
miao@lewoopharma.com.cn
Country
China
ProdList
698
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
More
Less

View Lastest Price from 4-Phenylbutyric acid manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
4-Phenylbutyric acid 1821-12-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31
Hebei Yanxi Chemical Co., Ltd.
Product
4-Phenylbutyric acid 1821-12-1
Price
US $30.00-3.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
15 tons
Release date
2023-10-08
Shanghai Joiny Pharmaceutical Co.,LTD
Product
4-Phenylbutyric acid 1821-12-1
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500kg
Release date
2022-12-09

1821-12-1, 4-Phenylbutyric acidRelated Search:


  • PHENYLBUTYRIC-4 ACID
  • PHENYLBUTYRIC ACID
  • GAMMA-PHENYL-N-BUTYRIC ACID
  • GAMA-PHENYLBUTYRIC ACID
  • AKOS BBS-00003749
  • 4-PHENYL-N-BUTYRIC ACID
  • 4-PHENYLBUTANOIC ACID
  • 4-PHENYLBUTYRIC ACID
  • Benzenebutanoic acid
  • benzenebutanoicacid
  • Benzenebutyric acid
  • Butyric acid, 4-phenyl-
  • gamma-Phenylbutyric acid
  • omega-Phenylbutanoic acid
  • 4-PHENYBUTYTIC ACID
  • 4-PhenylButyricAcid99%
  • 4- Phenyl Butyric Acid 99%
  • 4-Phenylbutyricacid98%
  • 4-Phenylbutyric acid 4-phenylbutanoic acid
  • 4-PHENYLBUTYRIC ACID pure
  • TIMTEC-BB SBB008452
  • RARECHEM AL BO 0178
  • Buphenyl
  • 4-Phenylbutanoic acid 98%
  • 4-Phenylbutyric acid≥ 99% (Assay)
  • 4-benzene acid
  • NSC 295
  • γ-Phenylbutanoic Acid
  • 4-Phenylbutyric Acid, 97+%
  • 4-PhenylbutyricAcid&gt
  • 4-Phenylbutyric acid (4-PBA)
  • p-Phenylbutyric acid
  • 4-Phenyl butyroic acid
  • Cinacalcet Impurity 6 (4-Phenylbutyric Acid)
  • 4-PHENYLBUTYRIC ACID Extra Pure
  • Entacapone Impurity 35
  • 4-Phenylbutyric Acid, ≥ 98.0%
  • Phenylbutyrate (Acid)
  • 1821-12-1
  • 217-341-8
  • 1821-12-2
  • 1821-12-9
  • C6H5CH23CO2H
  • C6H5CH23COOH
  • C10
  • Carboxylic Acids
  • Carbonyl Compounds
  • Building Blocks
  • Organic Building Blocks
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Carbonyl Compounds
  • Carboxylic Acids
  • Organic acids
  • Pharmaceutical Raw Materials
  • C10