4-(4-Aminophenyl)butyric acid
- Product Name
- 4-(4-Aminophenyl)butyric acid
- CAS No.
- 15118-60-2
- Chemical Name
- 4-(4-Aminophenyl)butyric acid
- Synonyms
- AKOS BB-8810;4-Amino-benzenebutanoic;p-Aminophenylbutyricacid;4-Aminophenylbutyric Acid;4-Aminobenzenebutanoic acid;4-(4-AMINOPHENYL)BUTYRIC ACID;4-(4-Aminophenyl)butanoicacid;Benzenebutanoic acid, 4-amino-;4-(4-azanylphenyl)butanoic acid;4-(4-AMinophenyl)butyric acid 95%
- CBNumber
- CB9479760
- Molecular Formula
- C10H13NO2
- Formula Weight
- 179.22
- MOL File
- 15118-60-2.mol
4-(4-Aminophenyl)butyric acid Property
- Melting point:
- 121-124 °C (lit.) 121-133 °C
- Boiling point:
- 363.7±17.0 °C(Predicted)
- Density
- 1.177±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.70±0.10(Predicted)
- color
- Light Beige to Light Brown
- Major Application
- peptide synthesis
- InChI
- InChI=1S/C10H13NO2/c11-9-6-4-8(5-7-9)2-1-3-10(12)13/h4-7H,1-3,11H2,(H,12,13)
- InChIKey
- RBHLFWNKEWLHBP-UHFFFAOYSA-N
- SMILES
- C1(CCCC(O)=O)=CC=C(N)C=C1
- CAS DataBase Reference
- 15118-60-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 335339
- Product name
- 4-(4-Aminophenyl)butyric acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $62.9
- Updated
- 2026/03/19
- Product number
- 335339
- Product name
- 4-(4-Aminophenyl)butyric acid
- Purity
- 95%
- Packaging
- 5g
- Price
- $227
- Updated
- 2026/03/19
- Product number
- FA11725
- Product name
- 4-(4-Aminophenyl)butyric acid
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FA11725
- Product name
- 4-(4-Aminophenyl)butyric acid
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- R797
- Product name
- 4-Aminophenylbutyricacid
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
4-(4-Aminophenyl)butyric acid Chemical Properties,Usage,Production
Description
4-(4-Aminophenyl)butyric acid (4-APB) is an important organic compound derived from butyric acid, which is used as a synthetic intermediate for pharmaceuticals or the synthesis of various compounds. It is also used in drug mechanism studies and is thought to be an agonist for certain G-protein coupled receptors and may also interact with other proteins in the signal transduction pathway. In addition, 4-(4-aminophenyl)butyric acid has been found to inhibit monoamine oxidase, which plays a role in neurotransmitter catabolism.
Uses
4-(4-Aminophenyl)butyric Acid is a degradation product of Chlorambucil (C325050); an alkylating agent that is used as an chemotherapy drug in the treatment of chronic lymphocytic leukemia. Chlorambucil is also used to treat non-Hodgkin''s lymphoma (NHL) and Hodgkin''s disease.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
5473-15-4
15118-60-2
The general procedure for the synthesis of 4-(4-aminophenyl)butyric acid from 4-(4-acetamidophenyl)-4-oxobutanoic acid was as follows: 89 g of 3-(4-acetamidophenyl)propionic acid, 88 g of potassium hydroxide, 65 ml of 85% hydrazine hydrate and 450 ml of diethylene glycol were mixed and heated and refluxed for 1.5 hours. Subsequently, the reaction temperature was raised to 150°C to remove excess hydrazine hydrate and the reaction was maintained at this temperature for 4 hours. Upon completion of the reaction, it was cooled to room temperature, 400 g of water was added, and the pH was adjusted to 6 with 6N hydrochloric acid, and then adjusted to 5-6 with glacial acetic acid. at this point, the target product precipitated as crystals, and after filtration, washing and drying, 44 g of white or near-white crystals were obtained in 95% yield.
References
[1] Patent: CN104447376, 2016, B. Location in patent: Paragraph 0032-0033; 0043-0044
[2] European Journal of Medicinal Chemistry, 2018, vol. 146, p. 588 - 598
4-(4-Aminophenyl)butyric acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-(4-Aminophenyl)butyric acid manufacturers
- Product
- 4-(4-Aminophenyl)butyric acid 15118-60-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-18
- Product
- 4-(4-Aminophenyl)butyric acid 15118-60-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 4-(4-Aminophenyl)butyric acid 15118-60-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09