4-Phenylbutyric acid

Product Name: 4-Phenylbutyric acid
CAS No.: 1821-12-1
Chemical Name: 4-Phenylbutyric acid
Synonyms: 4-PHENYLBUTANOIC ACID;PHENYLBUTYRIC ACID;Benzenebutanoic acid;Buphenyl;PHENYLBUTYRIC-4 ACID;NSC 295;4-benzene acid;AKOS BBS-00003749;Benzenebutyric acid;benzenebutanoicacid
CBNumber: CB2385237
Molecular Formula: C10H12O2
Formula Weight: 164.2
MOL File: 1821-12-1.mol

More

Less

4-Phenylbutyric acid Property

Melting point:: 49-51 °C(lit.)
Boiling point:: 165 °C10 mm Hg(lit.)
Density: 1.0326 (rough estimate)
refractive index: 1.5405 (estimate)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
solubility: 5.3g/l. Almost insoluble in water, soluble in alcohol and oils
form: Crystalline Powder
pka: 4.76(at 25℃)
color: White to slightly yellow
Water Solubility: 5.3 g/L at 40 ºC
BRN: 638180
InChIKey: OBKXEAXTFZPCHS-UHFFFAOYSA-N
LogP: 2.420
CAS DataBase Reference: 1821-12-1(CAS DataBase Reference)
NIST Chemistry Reference: 4-Phenylbutanoic acid(1821-12-1)
EPA Substance Registry System: 4-Phenylbutyric acid (1821-12-1)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HS Code: 29163900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P21005
Product name: 4-Phenylbutyric acid
Purity: 99%
Packaging: 25g
Price: $66.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: P21005
Product name: 4-Phenylbutyric acid
Purity: 99%
Packaging: 100g
Price: $161
Updated: 2024/03/01

TCI Chemical

Product number: P0643
Product name: 4-Phenylbutyric Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $56
Updated: 2024/03/01

TCI Chemical

Product number: P0643
Product name: 4-Phenylbutyric Acid
Purity: >98.0%(GC)(T)
Packaging: 250g
Price: $297
Updated: 2024/03/01

Alfa Aesar

Product number: A18115
Product name: 4-Phenylbutyric acid, 99%
Packaging: 25g
Price: $54.65
Updated: 2024/03/01

More

Less

4-Phenylbutyric acid Chemical Properties,Usage,Production

Chemical Properties

4-Phenylbutyric acid is white to slightly yellowish crystalline powder. It is slightly soluble in chloroform and methanol. Its solubility in water is 5.3 g/l (at 40 °C).

Uses

4-Phenylbutyric acid is used as a chemical chaperone involved in protein-folding disorders. It is involved in the synthesis of dyes and an active pharmaceutical ingredient intermediate.

Preparation

4-phenylbutyric acid is obtained by the reaction of benzene with butyrolactone in the presence of aluminum chloride, followed by neutralization with base.
Synthesis of 4-phenylbutyric acid

Application

4-Phenylbutyric acid (4-PBA) is used in the treatment of urea cycle disorders under the trade name Buphenyl. 4-PBA has been used as a selective inhibitor of endoplasmic reticulum stress (ERS).
4-Phenylbutyric acid is used as organic intermediates. It can also be used as a reactant in the synthesis of:
1-Tetralone using Lewis acid catalyst.
4,N-diphenylbutyramide.

Definition

4-Phenylbutyric acid is a monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apopto is in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 3309, 1991 DOI: 10.1016/S0040-4039(00)92693-5

General Description

4-Phenylbutyric acid (4-PBA) is a small-molecular-weight fatty acid with a terminal aromatic group, and its sodium salt (sodium 4-phenyl butyrate) has been used for the treatment of urea cycle disorders. This molecule is also used for the treatment of sickle cell diseases and thalassemia owing to its ability to activate β-globin transcription. Moreover, 4-PBA is employed as an orally bioavailable agent for the treatment of spinal muscular atrophy (SMA) and tumors.
Neuroprotective Effects of 4-phenylbutyric Acid and Its Derivatives: Possible Therapeutics for Neurodegenerative Diseases

Purification Methods

Crystallise the acid from pet ether (b 40-60o). [Beilstein 9 IV 1811.]

4-Phenylbutyric acid Preparation Products And Raw materials

Raw materials

Acetone Carbon tetrachloride Aluminum chloride Benzene Hydrochloric acid Methanol Sodium hydroxide Activated carbon Gamma Butyrolactone

Preparation Products

METHYL 3-(4-CHLOROSULFONYL)PHENYLPROPIONATE Methyl 4-phenylbutanoate Imidapril Chlorambucil 1-Tetralone ETHYL 4-PHENYLBUTYRATE METHYL 4-(4-(BIS(2-CHLOROETHYL)AMINO)PHENYL)BUTYRATE

More

Less

4-Phenylbutyric acid Suppliers

Americas 1 Belgium 3 Canada 3 China 312 Europe 4 Germany 13 India 50 Italy 1 Japan 6 Norway 1 Poland 1 Slovakia 1 Switzerland 2 Ukraine 2 United Kingdom 13 United States 58 USA 1 Global 472

BTC pharm India

Tel: +918790379245
Email: banny.janga@btcpharm.com
Country: India
ProdList: 1262
Advantage: 58

GLR Innovations

Tel: +91 9891111994
Email: info@glrgroup.in
Country: India
ProdList: 4535
Advantage: 58

TCI Chemicals (India) Pvt. Ltd.

Tel: --
Fax: --
Email: sales-in@tcichemicals.com
Country: India
ProdList: 6768
Advantage: 58

Sisco Research Laboratories Pvt. Ltd.

Tel: --
Fax: --
Email: marketing@srlchem.com
Country: India
ProdList: 4315
Advantage: 58

Triveni chemicals

Tel: --
Fax: --
Email: sales@trivenichemical.com
Country: India
ProdList: 6088
Advantage: 58

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: India
ProdList: 6905
Advantage: 58

Sakam Finechem Pvt., Ltd.

Tel: --
Fax: --
Email: info@sakamfinechem.com
Country: India
ProdList: 556
Advantage: 58

Suvchem

Tel: --
Fax: --
Email: sales@suvchem.com
Country: India
ProdList: 180
Advantage: 58

Chaturya Biotech (Tanuj Life Sciences)

Tel: --
Fax: --
Email: info@chaturyabiotech.com
Country: India
ProdList: 398
Advantage: 58

ASM Organics

Tel: --
Fax: --
Country: India
ProdList: 1185
Advantage: 58

VASIN BIO LIFE SCIENCES PVT LTD

Tel: --
Fax: --
Email: info@vasinbio.com
Country: India
ProdList: 2092
Advantage: 58

Glenfin Chemicals Pvt. Ltd.

Tel: --
Fax: --
Email: marketing@glenfinchemicals.com
Country: India
ProdList: 30
Advantage: 58

Nirmal Chemicals

Tel: --
Fax: --
Country: India
ProdList: 18
Advantage: 58

Renuka Interchem

Tel: --
Fax: --
Country: India
ProdList: 116
Advantage: 58

Opulent Pharma

Tel: --
Fax: --
Country: India
ProdList: 810
Advantage: 58

Oceanic Pharmachem Pvt., Ltd. (OPPL)

Tel: --
Fax: --
Email: info@oceanicpharmachem.com
Country: India
ProdList: 946
Advantage: 58

Snap Intermediates

Tel: --
Fax: --
Country: India
ProdList: 110
Advantage: 58

HiMedia Laboratories

Tel: --
Fax: --
Email: o@himedialabs.com
Country: India
ProdList: 1841
Advantage: 58

Anand Agencies

Tel: --
Fax: --
Email: en@gmail.com
Country: India
ProdList: 2332
Advantage: 58

MALLADI DRUGS AND PHARMACEUTICALS LTD

Tel: --
Fax: --
Email: info@malladi.co.in
Country: India
ProdList: 44
Advantage: 58

Gliesse Pharmaceuticals Pvt., Ltd.

Tel: --
Fax: --
Email: info@gliessepharma.com
Country: India
ProdList: 165
Advantage: 58

V & V Pharma Industries

Tel: --
Fax: --
Country: India
ProdList: 98
Advantage: 58

Pratap Organics Pvt. Ltd.

Tel: --
Fax: --
Country: India
ProdList: 87
Advantage: 58

Saisri Hetero Cyclics (SSH)

Tel: --
Fax: --
Email: srisai@sriheterocyclics.com
Country: India
ProdList: 262
Advantage: 58

Sai Sree Chemicals

Tel: --
Fax: --
Email: saisreechemicals205@gmail.com
Country: India
ProdList: 89
Advantage: 58

Pratap Organics Private Limited

Tel: --
Fax: --
Country: India
ProdList: 32
Advantage: 58

Ultima Chemicals

Tel: --
Fax: --
Country: India
ProdList: 182
Advantage: 58

Chempure

Tel: --
Fax: --
Country: India
ProdList: 144
Advantage: 58

LOBA CHEMIE PVT.LTD.

Tel: --
Fax: --
Email: info@lobachemie.com
Country: India
ProdList: 3075
Advantage: 58

Central Drug House(P) Ltd.

Tel: --
Fax: --
Email: sales@cdhfinechemical.com
Country: India
ProdList: 6157
Advantage: 58

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

Pratap Organics Pvt. Ltd.

Tel: --
Fax: --
Email: pratap1@bom3.vsnl.net.in
Country: India
ProdList: 80
Advantage: 50

Avra Synthesis Pvt Ltd

Tel: --
Fax: --
Email: info@avrasynthesis.com
Country: India
ProdList: 1603
Advantage: 30

CHEMSWORTH

Tel: --
Fax: --
Email: info@chemsworth.com
Country: India
ProdList: 6700
Advantage: 30

More

Less

View Lastest Price from 4-Phenylbutyric acid manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Phenylbutyric acid 1821-12-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-31

Hebei Yanxi Chemical Co., Ltd.

Product: 4-Phenylbutyric acid 1821-12-1
Price: US $30.00-3.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 15 tons
Release date: 2023-10-08

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 4-Phenylbutyric acid 1821-12-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg
Release date: 2022-12-09

1821-12-1, 4-Phenylbutyric acidRelated Search:

Hydrocortisone-17-butyrate 4-Aminobutyric acid Indole-3-butyric acid Isobutyric acid Butyric Acid 4-Phenylbutanol Chlorambucil (E)-1-HEXENE-1,2-DIBORONIC ACID BIS(PINACOL) ESTER N-TETRADECYLBORONIC ACID 1-Nonaneboronic acid FERROCENEBORONIC ACID 1-Hexaneboronic acid 1-CIS-1,2-BIS(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)HEPTENE 4-(4-Aminophenyl)butyric acid CYCLOPENTEN-1-YLBORONIC ACID 1-Octylboronic acid Cyclopentylboronic acid (R)-(-)-2-HYDROXY-4-PHENYLBUTYRIC ACID

PHENYLBUTYRIC-4 ACID

PHENYLBUTYRIC ACID

GAMMA-PHENYL-N-BUTYRIC ACID

GAMA-PHENYLBUTYRIC ACID

AKOS BBS-00003749

4-PHENYL-N-BUTYRIC ACID

4-PHENYLBUTANOIC ACID

4-PHENYLBUTYRIC ACID

Benzenebutanoic acid

benzenebutanoicacid

Benzenebutyric acid

Butyric acid, 4-phenyl-

gamma-Phenylbutyric acid

omega-Phenylbutanoic acid

4-PHENYBUTYTIC ACID

4-PhenylButyricAcid99%

4- Phenyl Butyric Acid 99%

4-Phenylbutyricacid98%

4-Phenylbutyric acid 4-phenylbutanoic acid

4-PHENYLBUTYRIC ACID pure

TIMTEC-BB SBB008452

RARECHEM AL BO 0178

Buphenyl

4-Phenylbutanoic acid 98%

4-Phenylbutyric acid≥ 99% (Assay)

4-benzene acid

NSC 295

γ-Phenylbutanoic Acid

4-Phenylbutyric Acid, 97+%

4-PhenylbutyricAcid&gt

4-Phenylbutyric acid (4-PBA)

p-Phenylbutyric acid

4-Phenyl butyroic acid

Cinacalcet Impurity 6 (4-Phenylbutyric Acid)

4-PHENYLBUTYRIC ACID Extra Pure

Entacapone Impurity 35

4-Phenylbutyric Acid, ≥ 98.0%

Phenylbutyrate (Acid)

1821-12-1

217-341-8

1821-12-2

1821-12-9

C6H5CH23CO2H

C6H5CH23COOH

C10

Carboxylic Acids

Carbonyl Compounds

Building Blocks

Organic Building Blocks

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Carbonyl Compounds

Carboxylic Acids

Organic acids

Pharmaceutical Raw Materials

C10