ChemicalBook > CAS DataBase List > 1-Methyl-4-(3-chloropropyl)piperazine

1-Methyl-4-(3-chloropropyl)piperazine

Product Name: 1-Methyl-4-(3-chloropropyl)piperazine
CAS No.: 104-16-5
Chemical Name: 1-Methyl-4-(3-chloropropyl)piperazine
Synonyms: n-methylpiperazinopropyl chloride;1-(3-chloropropyl)-4-methyl-piperazin;1-Methyl-4-(3-chloropropyl)piperazine;3-(4-Methylpiperazino)propyl chloride;1-(3-Chloropropyl)-4-methylpiperazine;N-(3-Chloropropyl)-N'-methylpiperazine;Piperazine, 1-(3-chloropropyl)-4-methyl-;1-(3-Chloroprop-1-yl)-4-methylpiperazine;1-Chloro-3-(4-Methyl-1-piperazinyl)propane;1-(3-chloro-propyl)-4-methyl-piperazine(Dihydrochlorideform)
CBNumber: CB5874738
Molecular Formula: C8H17ClN2
Formula Weight: 176.69
MOL File: 104-16-5.mol

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1-Methyl-4-(3-chloropropyl)piperazine Property

Melting point:: 128-130 °C(Solv: acetone (67-64-1))
Boiling point:: 243 ºC
Density: 1.015
refractive index: 1.476
Flash point:: 101 ºC
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: 7?+-.0.10(Predicted)
InChI: InChI=1S/C8H17ClN2/c1-10-5-7-11(8-6-10)4-2-3-9/h2-8H2,1H3
InChIKey: AUERUDPETOKUPT-UHFFFAOYSA-N
SMILES: N1(CCCCl)CCN(C)CC1

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C380670
Product name: 1-(3-Chloropropyl)-4-methylpiperazine
Packaging: 2.5g
Price: $385
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20376
Product name: 1-(3-Chloropropyl)-4-methylpiperazine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20376
Product name: 1-(3-Chloropropyl)-4-methylpiperazine
Packaging: 100mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20376
Product name: 1-(3-Chloropropyl)-4-methylpiperazine
Packaging: 250mg
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: X8701
Product name: 1-(3-chloropropyl)-4-methylpiperazine
Packaging: 1g
Price: $185
Updated: 2021/12/16

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1-Methyl-4-(3-chloropropyl)piperazine Chemical Properties,Usage,Production

Uses

1-(3-Chloropropyl)-4-methylpiperazine is a reactant in the synthesis of pyrimidines as a novel sigma-1 receptor antagonist for treating neuropathic pain

Uses

1-Methyl-4-(3-chloropropyl)piperazine can be used in the preparation of many pharmaceutically active compounds such as antiulcer agents, antitumor agents, antibiotics and anxiolytics.

Synthesis

109-01-3

109-70-6

104-16-5

General procedure: 1-bromo-3-chloropropane (0.25 mL) was slowly added dropwise to a solution of N-methylpiperazine (0.55 mL) in toluene (2.5 mL) and the reaction was stirred at 80°C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and acidified by slowly adding 2 mol/L hydrochloric acid solution. The aqueous phase was separated and the pH was adjusted to 12 with 2 mol/L aqueous sodium hydroxide solution, followed by the addition of ethyl acetate for extraction. The organic phase was collected, washed with saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give 1-(3-chloropropyl)-4-methylpiperazine (187 mg) as a white solid.1H-NMR (CDCl3) δ: 3.59 (2H, t, J = 6.6 Hz), 2.49 (8H, t, J = 7.3 Hz), 2.29 (3H, s), 1.95 (2H, t, J = 6.9 Hz).

References

[1] Pharmazie, 2005, vol. 60, # 6, p. 411 - 414
[2] Synthetic Communications, 2003, vol. 33, # 14, p. 2483 - 2486
[3] Pharmazie, 1980, vol. 35, # 2, p. 69 - 72
[4] Pharmaceutical Chemistry Journal, 1998, vol. 32, # 7, p. 362 - 369
[5] Farmaco, 1993, vol. 48, # 12, p. 1641 - 1648

1-Methyl-4-(3-chloropropyl)piperazine Preparation Products And Raw materials

Raw materials

1-Chloropropane

Preparation Products

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View Lastest Price from 1-Methyl-4-(3-chloropropyl)piperazine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Methyl-4-(3-chloropropyl)piperazine 104-16-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

Shaanxi Dideu Medichem Co. Ltd

Product: 1-Methyl-4-(3-chloropropyl)piperazine 104-16-5
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KG
Release date: 2019-12-30

Shaanxi Dideu Medichem Co. Ltd

Product: 1-Methyl-4-(3-chloropropyl)piperazine 104-16-5
Price: US $1.00-1.00/Kg/Drum
Min. Order: 1KG
Purity: 99%+
Supply Ability: 100 tons
Release date: 2019-12-26

104-16-5, 1-Methyl-4-(3-chloropropyl)piperazineRelated Search:

1-(2-METHOXYPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE DIHYDROCHLORIDE 1-(3-chloropropanoyl)-4-methylpiperazine 3-chloro-1-[4-(3-chlorophenyl)piperazin-1-yl]propan-1-one 3-chloro-1-(4-phenylpiperazin-1-yl)propan-1-one 1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride 1-(4-benzylpiperazin-1-yl)-3-chloropropan-1-one 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine 1-(3-chloropropanoyl)-4-ethylpiperazine 5-ALLYL-2,5-DICHLORO-4,4-DIMETHOXY-3-(4-METHYLPIPERAZIN-1-YL)CYCLOPENT-2-EN-1-ONE 1-(3-CHLOROPROPANOYL)-4-(4-FLUOROPHENYL)PIPERAZINE 1-Methyl-4-(3-chloropropyl)piperazine 1-(3-CHLOROPROPANOYL)-4-(2-FUROYL)PIPERAZINE 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride 4-(chloropropyl)-1-(2-quinolyl)piperazine RARECHEM BG FB 0118

1-Chloro-3-(4-Methyl-1-piperazinyl)propane

1-Methyl-4-(3-chloropropyl)piperazine

1-(3-chloropropyl)-4-methyl-piperazin

n-methylpiperazinopropyl chloride

3-(4-Methylpiperazino)propyl chloride

N-(3-Chloropropyl)-N'-methylpiperazine

1-(3-Chloropropyl)-4-methylpiperazine

1-(3-Chloroprop-1-yl)-4-methylpiperazine

1-(3-chloro-propyl)-4-methyl-piperazine(Dihydrochlorideform)

Piperazine, 1-(3-chloropropyl)-4-methyl-

104-16-5

Heterocycles

Intermediates

Miscellaneous Reagents