1-Methyl-4-(3-chloropropyl)piperazine
- Product Name
- 1-Methyl-4-(3-chloropropyl)piperazine
- CAS No.
- 104-16-5
- Chemical Name
- 1-Methyl-4-(3-chloropropyl)piperazine
- Synonyms
- n-methylpiperazinopropyl chloride;1-(3-chloropropyl)-4-methyl-piperazin;1-Methyl-4-(3-chloropropyl)piperazine;3-(4-Methylpiperazino)propyl chloride;1-(3-Chloropropyl)-4-methylpiperazine;N-(3-Chloropropyl)-N'-methylpiperazine;Piperazine, 1-(3-chloropropyl)-4-methyl-;1-(3-Chloroprop-1-yl)-4-methylpiperazine;1-Chloro-3-(4-Methyl-1-piperazinyl)propane;1-(3-chloro-propyl)-4-methyl-piperazine(Dihydrochlorideform)
- CBNumber
- CB5874738
- Molecular Formula
- C8H17ClN2
- Formula Weight
- 176.69
- MOL File
- 104-16-5.mol
1-Methyl-4-(3-chloropropyl)piperazine Property
- Melting point:
- 128-130 °C(Solv: acetone (67-64-1))
- Boiling point:
- 243 ºC
- Density
- 1.015
- refractive index
- 1.476
- Flash point:
- 101 ºC
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- pka
- 7?+-.0.10(Predicted)
- InChI
- InChI=1S/C8H17ClN2/c1-10-5-7-11(8-6-10)4-2-3-9/h2-8H2,1H3
- InChIKey
- AUERUDPETOKUPT-UHFFFAOYSA-N
- SMILES
- N1(CCCCl)CCN(C)CC1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C380670
- Product name
- 1-(3-Chloropropyl)-4-methylpiperazine
- Packaging
- 2.5g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- X8701
- Product name
- 1-(3-chloropropyl)-4-methylpiperazine
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 073968
- Product name
- 1-(3-Chloropropyl)-4-methylpiperazine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $336
- Updated
- 2021/12/16
- Product number
- FC20376
- Product name
- 1-(3-Chloropropyl)-4-methylpiperazine
- Packaging
- 1g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- FC20376
- Product name
- 1-(3-Chloropropyl)-4-methylpiperazine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
1-Methyl-4-(3-chloropropyl)piperazine Chemical Properties,Usage,Production
Uses
1-(3-Chloropropyl)-4-methylpiperazine is a reactant in the synthesis of pyrimidines as a novel sigma-1 receptor antagonist for treating neuropathic pain
Uses
1-Methyl-4-(3-chloropropyl)piperazine can be used in the preparation of many pharmaceutically active compounds such as antiulcer agents, antitumor agents, antibiotics and anxiolytics.
Synthesis
109-01-3
109-70-6
104-16-5
General procedure: 1-bromo-3-chloropropane (0.25 mL) was slowly added dropwise to a solution of N-methylpiperazine (0.55 mL) in toluene (2.5 mL) and the reaction was stirred at 80°C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and acidified by slowly adding 2 mol/L hydrochloric acid solution. The aqueous phase was separated and the pH was adjusted to 12 with 2 mol/L aqueous sodium hydroxide solution, followed by the addition of ethyl acetate for extraction. The organic phase was collected, washed with saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give 1-(3-chloropropyl)-4-methylpiperazine (187 mg) as a white solid.1H-NMR (CDCl3) δ: 3.59 (2H, t, J = 6.6 Hz), 2.49 (8H, t, J = 7.3 Hz), 2.29 (3H, s), 1.95 (2H, t, J = 6.9 Hz).
References
[1] Pharmazie, 2005, vol. 60, # 6, p. 411 - 414
[2] Synthetic Communications, 2003, vol. 33, # 14, p. 2483 - 2486
[3] Pharmazie, 1980, vol. 35, # 2, p. 69 - 72
[4] Pharmaceutical Chemistry Journal, 1998, vol. 32, # 7, p. 362 - 369
[5] Farmaco, 1993, vol. 48, # 12, p. 1641 - 1648
1-Methyl-4-(3-chloropropyl)piperazine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Methyl-4-(3-chloropropyl)piperazine Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 1-Methyl-4-(3-chloropropyl)piperazine manufacturers
- Product
- 1-Methyl-4-(3-chloropropyl)piperazine 104-16-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10
- Product
- 1-Methyl-4-(3-chloropropyl)piperazine 104-16-5
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KG
- Release date
- 2019-12-30
- Product
- 1-Methyl-4-(3-chloropropyl)piperazine 104-16-5
- Price
- US $1.00-1.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%+
- Supply Ability
- 100 tons
- Release date
- 2019-12-26