ChemicalBook > CAS DataBase List > clorexolone

clorexolone

Product Name
clorexolone
CAS No.
2127-01-7
Chemical Name
clorexolone
Synonyms
Klorex;12833 RP;Nefrolan;M&B 8430;RP 12833;RP-12833;Flonatril;clorexolone;Chlorexolone;clorexolone USP/EP/BP
CBNumber
CB5875104
Molecular Formula
C14H17ClN2O3S
Formula Weight
328.818
MOL File
2127-01-7.mol
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clorexolone Property

Melting point:
266-268°
storage temp. 
Refrigerator
solubility 
DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C327080
Product name
Chlorexolone
Packaging
50mg
Price
$1455
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
55521
Product name
Chlorexolone
Packaging
50mg
Price
$2200
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005529
Product name
CLOREXOLONE
Purity
95.00%
Packaging
5MG
Price
$500.68
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
55521
Product name
Chlorexolone
Packaging
5mg
Price
$650
Updated
2021/12/16
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clorexolone Chemical Properties,Usage,Production

Originator

Speciatensol,Specia,France,1966

Uses

Chlorexolone is a sulfonamide based antibiotic.

Uses

Chlorexolone is a low-ceiling sulfonamide diuretic.

Definition

ChEBI: Clorexolone is an organic molecular entity.

Manufacturing Process

4-Chlorophthalimide (263 g) was reacted in amyl alcohol (2.6 l) with cyclohexylamine (143.5 g, 1 mol) at reflux temperature for 16 hours to give N-cyclohexyl-4-chlorophthalimide (250 g, 66%) as a solid, MP 134°C to 136°C.
N-Cyclohexyl-1-chlorophthalimide (250 g) was dissolved in glacial acetic acid (2.5 l), concentrated hydrochloric acid (555 ml) and tin (278 g) were added and the suspension was heated on a steam bath for 16 hours. The cooled solution was filtered and concentrated to dryness in vacuo to give a white solid. This solid was dissolved in water and the precipitated oil extracted with chloroform. The chloroform solution was dried and concentrated in vacuo to give a solid which, after recrystallization, yielded 5-chloro-2- cyclohexylisoindolin-1-one (43%), MP 140°C to 142°C.
5-Chloro-2-cyclohexylisoindolin-1-one (102.9 g) was dissolved in concentrated sulfuric acid (665 ml); potassium nitrate (723 g) in concentrated sulfuric acid (166 ml) was added at 0 °C. The reaction mixture was allowed to warm to room temperature and stirred at 25°C for 12 hours. The reaction mixture was poured onto ice to give a cream solid which, after recrystallization from benzene, gave 5-chloro-2-cyclohexyl-6-nitroisoindolin-1-one (46.7 g, 44%) as a white solid, MP 164°C to 168°C.
5-Chloro-2-cyclohexyl-6-nitroisoindolin-1-one (93.9 g) was reduced in concentrated hydrochloric acid (1,970 ml) with stannous chloride (376 g). The reaction temperature rose to 70°C. The resulting solution was cooled in ice and filtered. The product was washed well with water, filtered and dried to give 6-amino-5-chloro-2-cyclohexylisoindolin-1-one (74.1 g, 87.6%) which, after recrystallization from benzene, had a MP of 216°C to 218°C.
6-Amino-5-chloro-2-cyclohexylisoindolin-1-one (42.5 g) was dissolved in concentrated hydrochloric acid (425 ml) and the solution diazotized by the addition of sodium nitrite (21.25 g) in water (125 ml). The resulting diazonium salt solution was added to a solution of liquid sulfur dioxide (93 ml) in glacial acetic acid (243 ml) containing cuprous chloride (2.25 g). A yellow solid was precipitated; this was filtered off, washed, dried and recrystallized from benzene to give 5-chloro-2-cyclohexylisoindolin-1-one-6-sulfonyl chloride (45 g, 80%) as a cream solid, MP 171°C to 174°C.
This sulfonyl chloride (23.7 g) was reacted with liquid ammonia (237 ml) to give 5-chloro-2-cyclohexyl-6-sulfamoylisoindolin-1-one (14.2 g, 53%). MP 259°C to 261°C.

Therapeutic Function

Diuretic

clorexolone Preparation Products And Raw materials

Raw materials

Preparation Products

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clorexolone Suppliers

J & K SCIENTIFIC LTD.
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+86-571-82880190
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Capot Chemical Co.,Ltd.
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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Shaanxi Dideu Medichem Co. Ltd
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Energy Chemical
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Sinoway Industrial co., ltd.
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Lanospharma Laboratories Co.,Ltd
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2127-01-7, clorexoloneRelated Search:


  • 12833 RP
  • 6-Chloro-2-cyclohexyl-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonamide
  • Flonatril
  • M&B 8430
  • Nefrolan
  • 6-chloro-2-cyclohexyl-3-keto-isoindoline-5-sulfonamide
  • 6-chloro-2-cyclohexyl-3-oxo-1H-isoindole-5-sulfonamide
  • Chlorexolone
  • clorexolone
  • 1H-Isoindole-5-sulfonamide, 6-chloro-2-cyclohexyl-2,3-dihydro-3-oxo-
  • clorexolone USP/EP/BP
  • Klorex
  • RP 12833
  • RP-12833
  • 2127-01-7