Mafenide acetate
- Product Name
- Mafenide acetate
- CAS No.
- 13009-99-9
- Chemical Name
- Mafenide acetate
- Synonyms
- Mefamide;mafatate;MARFANIL;MAFENIDE;maphenideacetate;MAFENIDE ACETATE;Sulfamylon Acetate;Mafenidine Acetate;MAFENAMIDE ACETATE;Sulfamimeron acetate
- CBNumber
- CB7750274
- Molecular Formula
- C9H14N2O4S
- Formula Weight
- 246.28
- MOL File
- 13009-99-9.mol
Mafenide acetate Property
- Melting point:
- 151-152°C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO: soluble1mg/mL
- form
- Solid
- color
- white
- CAS DataBase Reference
- 13009-99-9(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2935904000
- Toxicity
- LD50 in rats, mice (mg/kg): 2040, 1580 i.v. (Skulan, Hoppe)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 1373008
- Product name
- Mafenide Acetate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $453
- Updated
- 2024/03/01
- Product number
- M110200
- Product name
- Mafenide Acetate
- Packaging
- 25mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FA24972
- Product name
- 4-(Aminomethyl)benzenesulfonamide acetate
- Packaging
- 50g
- Price
- $52.5
- Updated
- 2021/12/16
- Product number
- CS-2839
- Product name
- Mafenide Acetate
- Purity
- 99.43%
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FA24972
- Product name
- 4-(Aminomethyl)benzenesulfonamide acetate
- Packaging
- 100g
- Price
- $79
- Updated
- 2021/12/16
Mafenide acetate Chemical Properties,Usage,Production
Chemical Properties
Crystalline Solid
Originator
Sulfamylon,Winthrop,US,1949
Uses
Antibacterial.
Definition
ChEBI: Mafenide acetate is a carboxylic acid.
Manufacturing Process
For the preparation of mafenide 50 g of acetylbenzylamine are introduced while stirring into 150 cc of chlorosulfonic acid, whereby the temperature is kept below 40°C by external cooling. After several hours' storing at ordinary temperature the mixture is heated for 1 hour in the boiling water-bath and after cooling, poured on to ice. Thereupon the 4-acetylaminoethylbenzenesulfonic acid chloride precipitates at first in an oily form, but solidifies after short stirring to crystals. The product sucked off and washed with cold water is introduced into a 10% aqueous ammonia solution. Thereby dissolution takes place while heating and after a short time the 4- acetylaminomethyl-benzenesulfonic acid amide precipitates in a crystalline form. After heating to 70°C for 30 minutes the solution is cooled, filtered with suction and washed out. The product is obtained when recrystallized from water or dilute alcohol in colorless crystals melting at 177%. It is readily soluble in warm water, extremely readily soluble in dilute sodium hydroxide solution.
brand name
Sulfamylon (Sterling Winthrop).
Therapeutic Function
Antibacterial
General Description
4-(Aminomethyl)benzenesulfonamide acetate (Sulfamylon)is a homologue of the sulfanilamide molecule. It is not atrue sulfanilamide-type compound, as it is not inhibited byPABA. Its antibacterial action involves a mechanism thatdiffers from that of true sulfanilamide-type compounds.
This compound is particularly effective against Clostridiumwelchii in topical application and was used duringWorld War II by the German army for prophylaxis ofwounds. It is not effective orally. It is currently used aloneor with antibiotics in the treatment of slow-healing, infectedwounds.
Some patients treated for burns with large quantities ofthis drug have developed metabolic acidosis. To overcomethis adverse effect, a series of new organic salts was prepared. The acetate in an ointment base proved to be themost efficacious.
Mafenide acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Mafenide acetate manufacturers
- Product
- Mafenide acetate 13009-99-9
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2023-07-21
- Product
- Mafenide acetate 13009-99-9
- Price
- US $555.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2000kg
- Release date
- 2021-06-08
- Product
- Mafenide acetate 13009-99-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-13