ChemicalBook > CAS DataBase List > Mafenide acetate

Mafenide acetate

Product Name
Mafenide acetate
CAS No.
13009-99-9
Chemical Name
Mafenide acetate
Synonyms
Mefamide;mafatate;MARFANIL;MAFENIDE;maphenideacetate;MAFENIDE ACETATE;Sulfamylon Acetate;Mafenidine Acetate;MAFENAMIDE ACETATE;Sulfamimeron acetate
CBNumber
CB7750274
Molecular Formula
C9H14N2O4S
Formula Weight
246.28
MOL File
13009-99-9.mol
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Mafenide acetate Property

Melting point:
151-152°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO: soluble1mg/mL
form 
Solid
color 
white
CAS DataBase Reference
13009-99-9(CAS DataBase Reference)
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Safety

WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2935904000
Toxicity
LD50 in rats, mice (mg/kg): 2040, 1580 i.v. (Skulan, Hoppe)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1373008
Product name
Mafenide Acetate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$453
Updated
2024/03/01
TRC
Product number
M110200
Product name
Mafenide Acetate
Packaging
25mg
Price
$50
Updated
2021/12/16
AK Scientific
Product number
J20650
Product name
4-(Aminomethyl)benzenesulfonamideacetate
Packaging
5g
Price
$35
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA24972
Product name
4-(Aminomethyl)benzenesulfonamide acetate
Packaging
50g
Price
$52.5
Updated
2021/12/16
ChemScene
Product number
CS-2839
Product name
Mafenide Acetate
Purity
99.43%
Packaging
50mg
Price
$60
Updated
2021/12/16
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Mafenide acetate Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Sulfamylon,Winthrop,US,1949

Uses

Antibacterial.

Definition

ChEBI: Mafenide acetate is a carboxylic acid.

Manufacturing Process

For the preparation of mafenide 50 g of acetylbenzylamine are introduced while stirring into 150 cc of chlorosulfonic acid, whereby the temperature is kept below 40°C by external cooling. After several hours' storing at ordinary temperature the mixture is heated for 1 hour in the boiling water-bath and after cooling, poured on to ice. Thereupon the 4-acetylaminoethylbenzenesulfonic acid chloride precipitates at first in an oily form, but solidifies after short stirring to crystals. The product sucked off and washed with cold water is introduced into a 10% aqueous ammonia solution. Thereby dissolution takes place while heating and after a short time the 4- acetylaminomethyl-benzenesulfonic acid amide precipitates in a crystalline form. After heating to 70°C for 30 minutes the solution is cooled, filtered with suction and washed out. The product is obtained when recrystallized from water or dilute alcohol in colorless crystals melting at 177%. It is readily soluble in warm water, extremely readily soluble in dilute sodium hydroxide solution.

brand name

Sulfamylon (Sterling Winthrop).

Therapeutic Function

Antibacterial

General Description

4-(Aminomethyl)benzenesulfonamide acetate (Sulfamylon)is a homologue of the sulfanilamide molecule. It is not atrue sulfanilamide-type compound, as it is not inhibited byPABA. Its antibacterial action involves a mechanism thatdiffers from that of true sulfanilamide-type compounds.
This compound is particularly effective against Clostridiumwelchii in topical application and was used duringWorld War II by the German army for prophylaxis ofwounds. It is not effective orally. It is currently used aloneor with antibiotics in the treatment of slow-healing, infectedwounds.
Some patients treated for burns with large quantities ofthis drug have developed metabolic acidosis. To overcomethis adverse effect, a series of new organic salts was prepared. The acetate in an ointment base proved to be themost efficacious.

Mafenide acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mafenide acetate manufacturers

Henan Bao Enluo International TradeCo.，LTD
Product
Mafenide acetate 13009-99-9
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-07-21
Baoji Guokang Healthchem co.,ltd
Product
Mafenide acetate 13009-99-9
Price
US $555.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
2000kg
Release date
2021-06-08
Dideu Industries Group Limited
Product
Mafenide acetate 13009-99-9
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-13

13009-99-9, Mafenide acetate Related Search:

Sulfasalazine Glatiramer acetate METSULFURON METHYL Vinyl acetate SULFOACETIC ACID DISODIUM SALT Fomesafen Foramsulfuron Trifluoromethanesulfonamide SULFENTRAZONE 2-Carbomethoxybenzenesulfonamide Tris(hydroxymethyl)aminomethane Benzenesulfonamide Sulfadiazine Methanesulfonamide Ethyl acetate 4-(AMINOMETHYL)BENZENESULFONAMIDE Sulfamethoxazole Butyl acetate

  • 4-aminomethylbenzenesulfonamide acetate salt
  • 4-(aminomethyl)benzenesulfonamidemonoacetate
  • 4-(aminomethyl)benzenesulfonimideacetate
  • Mafenide Acetate (400 mg)
  • Methotroxate Disodium
  • α-AMINO-P-TOLUENSULFONAMIDEMONOACETATE
  • A-AMINO-P-TOLUENSULFONAMIDEMONOACETATE
  • Mefamide
  • Sulfamylon Acetate
  • α-Amino-p-toluenesulfonamide Acetate
  • a-Amino-p-toluenesulfonamide Acetate
  • Mafenide Acetate (200 mg)
  • Mafenide acetate, >=99%
  • 4-HOMOSULFANILAMIDE ACETATE
  • 4-HOMOSULFANILAMIDE ACETATE SALT
  • 4-(AMINOMETHYL)-BENZENESULFOAMIDE MONOACETATE
  • 4-(AMINOMETHYL)BENZENESULFONAMIDE ACETATE
  • ALPHA-AMINO-P-TOLUENSULFONAMIDE MONOACETATE
  • P-(AMINOMETHYL) BENZENESULFONAMIDE ACETATE
  • P-AMINOMETHYLBENZENESULFONAMIDE ACETATE SALT
  • alpha-aminotoluene-4-sulphonamide monoacetate
  • Mafenidine Acetate
  • MAFENIDE ACETATE, 4-(AMINOMETHYL)-BENZENESULFOAMIDE MONOACETATE
  • 4-(aminomethyl)-benzenesulfonamidmonoacetate
  • alpha-amino-p-toluenesulfonamidmonoacetate
  • mafatate
  • maphenideacetate
  • MARFANIL
  • MARFANIL ACETATE SALT
  • MAFENAMIDE ACETATE
  • MAFENIDE
  • MAFENIDE ACETATE
  • MAFENIDE ACETATE SALT
  • Benzenesulfonamide, 4-(aminomethyl)-, acetate (1:1)
  • Mafenide acetate USP/EP/BP
  • Mafenide Acetate (1373008)
  • Sulfamimeron acetate
  • 13009-99-9
  • C7H10N2O2SC2H4O2
  • C2H4O2C7H10N2O2S
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