Lasalocid
- Product Name
- Lasalocid
- CAS No.
- 25999-31-9
- Chemical Name
- Lasalocid
- Synonyms
- Lasalocid;Aids003766;Lasalocid A;Aids-003766;Ionophore X-537A;Antibiotic X-537A;X 537A, Lasalocid A;Nsc243046 (sodium salt);25999-20-6 (Sodium salt);6-{7-[(5S)-5-((6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-5-ethyl-3-methyloxolan-2-yl](4S,5S,3R,7R)-4-hydroxy-3,5-dimethyl-6-oxononyl}-2-hydroxy-3-methylbenzoic acid
- CBNumber
- CB5875179
- Molecular Formula
- C34H54O8
- Formula Weight
- 590.79
- MOL File
- 25999-31-9.mol
Lasalocid Property
- Melting point:
- 110-114°; mp 100-109° (unsharp)
- alpha
- D25 -7.55° (methanol)
- Boiling point:
- 735.7±60.0 °C(Predicted)
- Density
- 1.119±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Acetonitrile,(Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- 3.15±0.39(Predicted)
- color
- White to Off-White
Safety
- Toxicity
- LD50 in mice (mg/kg): 40 i.p. (Berger); also reported as LD50 in mice (mg/kg): 146 orally, 64 i.p., J. W. Westley, "Antibiotics (Polyether)" in Kirk-Othmer Encyclopedia of Chemical Technology Vol. 3 (Interscience, New York, 3rd ed., 1978) p 61
N-Bromosuccinimide Price
- Product number
- 15505
- Product name
- Lasalocid
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $171
- Updated
- 2024/03/01
- Product number
- 15505
- Product name
- Lasalocid
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $634
- Updated
- 2024/03/01
- Product number
- 453557
- Product name
- Lasalocid
- Packaging
- 5mg
- Price
- $523
- Updated
- 2021/12/16
- Product number
- L1381
- Product name
- Lasalocid A
- Packaging
- 500ul
- Price
- $393
- Updated
- 2021/12/16
- Product number
- CS-4627
- Product name
- Lasalocid
- Purity
- >98.0%
- Packaging
- 50mg
- Price
- $450
- Updated
- 2021/12/16
Lasalocid Chemical Properties,Usage,Production
Description
Lasalocid is an ionophore antibiotic isolated from certain Streptomyces sp. and used in veterinary practice as a coccidiostat for gastrointestinal parasites. Lasalocid cytotoxicity targets cell metabolism, demonstrating EC50 values in the range of 7-
Uses
Lasalocid is a polyether ionophore with potent antibacterial activity isolated from Streptomyces lasaliensis, first reported in 1951. Lasalocid was developed as an animal health product for treatment of coccidia. Lasalocid is able to form neutral complexes with monovalent and divalent cations and transport the ions through apolar phase (including lipid bilayer membranes). Interestingly, lasalocid can also transport larger organic cations, e.g. protonated dopamine.
Uses
Lasalocid is an anticancer supplement agent comprising of polyether antibiotic for treating brain tumors, also inhibits mitochondrial GPD2 activity and elicits anti-proliferative effects on cancer cells.
Definition
ChEBI: Lasalocid is a polyether antibiotic used for prevention and treatment of coccidiosis in poultry. It has a role as a coccidiostat, a bacterial metabolite and an ionophore. It is a monohydroxybenzoic acid, a beta-hydroxy ketone, a secondary alcohol, a member of oxolanes, a monocarboxylic acid, a member of oxanes, a tertiary alcohol and a polyether antibiotic. It is a conjugate acid of a lasalocid(1-).
brand name
Avatec [as sodium] [Veterinary] (Hoffmann-LaRoche); Bovatec [as sodium] [Veterinary] (Hoffmann-LaRoche).
General Description
Lasalocid is one of the polyether ionophore antibiotics and was found in the culture broth of Streptomyces lasaliensis by Hoffmann-La Roche in 195. It shows activity against gram-positive bacteria, including Mycobacterium and Streptomyces, and also against anaerobic bacteria, but it has no activity against gramnegative bacteria or fungi. Lasalocid also shows strong anticoccidial activity, and it stimulates propionic acid formation in the rumen. It is used for prophylaxis and for therapy of coccidial infections in poultry and as a feed additive for growth promotion in cattle.
in vitro
a previous study was conducted to compare effects of the combined use of lasalocid and silybin in chicken hepatoma cells and rat myoblasts cell lines cultures. results showed that in all performed tests, the lowest lasalocid ec50-values were obtained for chicken hepatocytes. in the rat myoblasts cultures, the lowest lasalocid ec50-values were found. moreover, a lack of silybin cytotoxic effect was proven for the studied cell lines. an interaction between both substances resulted in a great decrease of lasalocid cytotoxicity. the isobolograms and combination index indicated a significant antagonistic nature of silybin effect in the course of lasalocid cytotoxicity [1].
in vivo
in a animal study, chickens 8 or 9 days old were given a completely purified crystalline amino acid diet. results showed that the requirement for sulphur-containing amino acids (saa) was neither increased nor decreased by lasalocid at 125 mg/kg diet. moreover, lasalocid could cause a significant increase in gain and gain/feed intake when added to diets that were deficient in saa, but it led to a marked decrease in performance when added to diets adequate in saa. in addition, at moderate levels of saa deficiency, lasalocid at 125 mg/kg could neither increase nor decrease the rate and efficiency of weight gain and there was no evidence of the saa x lasalocid interaction when lasalocid was given in a typical starter diet of maize and soya [2].
References
[1] radko, l. ,cybulski, w., and rzeski, w. the protective effect of silybin against lasalocid cytotoxic exposure on chicken and rat cell lines. biomed.res.int. 2013, 1-8 (2013).
[2] willis gm, baker dh. lasalocid-sulfur amino acid interrelationship in the chick. poult sci. 1980 nov;59(11):2538-43.
Lasalocid Preparation Products And Raw materials
Raw materials
Preparation Products
Lasalocid Suppliers
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 022-6537-8550 15522853686
- Fax
- 022-2532-9655
- sales@altasci.com.cn
- Country
- China
- ProdList
- 4511
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 4028
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57423
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- +86-0571-85134551
- Fax
- 008657185134895
- sales@afinechem.com
- Country
- China
- ProdList
- 15352
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 400-820-6829
- sales@mitachieve.com
- Country
- China
- ProdList
- 8860
- Advantage
- 58
- Tel
- 0571-89903882 13626641628
- jiangnan@huidabiotech.com
- Country
- China
- ProdList
- 3656
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44806
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 13348960310 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 10011
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 18661161657
- yaoxiangqiu2021@163.com
- Country
- China
- ProdList
- 9996
- Advantage
- 58
- Tel
- 0571-0571-89903882 15990081639
- sunshixuan@huidabiotech.com
- Country
- China
- ProdList
- 3705
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24644
- Advantage
- 58
- Tel
- 18621169109
- market03@meryer.com
- Country
- China
- ProdList
- 27987
- Advantage
- 58
- Tel
- 18014399201
- sales@chemlab-tachizaki.com
- Country
- China
- ProdList
- 2612
- Advantage
- 58
- Tel
- 021-58000709 15900491054
- info@scrbio.com
- Country
- China
- ProdList
- 10329
- Advantage
- 58
- Tel
- 0513-66337626 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 4988
- Advantage
- 58
- Tel
- 4001-009266 17349750668
- product@sci-e.com
- Country
- China
- ProdList
- 2808
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9266
- Advantage
- 58
- Tel
- 4008-099-669
- 23419001name@qq.com
- Country
- CHINA
- ProdList
- 73043
- Advantage
- 58
- Tel
- 18917019315 18917019315
- 18917019315@163.cn
- Country
- China
- ProdList
- 9162
- Advantage
- 58
- Tel
- +8613817748580
- Fax
- 021-50175322
- cooperation@kean-chem.com
- Country
- China
- ProdList
- 40066
- Advantage
- 58
- Tel
- +undefined18621343501
- product@acmec-e.com
- Country
- China
- ProdList
- 33338
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- 3245176082@qq.com
- Country
- CHINA
- ProdList
- 6134
- Advantage
- 58
- Tel
- --
- Fax
- --
- 3245176082@qq.com
- Country
- CHINA
- ProdList
- 6800
- Advantage
- 58
- Tel
- --
- Fax
- --
- shhebio@126.com
- Country
- CHINA
- ProdList
- 6137
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@lanospharma.com
- Country
- China
- ProdList
- 6329
- Advantage
- 56
- Tel
- --
- Fax
- --
- sales@viwachina.com
- Country
- China
- ProdList
- 372
- Advantage
- 51
- Tel
- --
- Fax
- --
- liujin1227@126.com
- Country
- China
- ProdList
- 414
- Advantage
- 30