Alclometasone

Product Name: Alclometasone
CAS No.: 67452-97-5
Chemical Name: Alclometasone
Synonyms: Vaderm;Alclometasone;AlcloMethasone;ALCLOMETHASONE DIPROPIONATE;7α-Chloro-16α-methylprednisolone;7α-Chloro-16α-methyl Prednisolone;7α-Chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione;(7α,11β,16α)-7-Chloro-11,17,21-trihydroxy-16-Methylpregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 7-chloro-11,17,21-trihydroxy-16-methyl-, (7α,11β,16α)-
CBNumber: CB5875588
Molecular Formula: C22H29ClO5
Formula Weight: 408.919
MOL File: 67452-97-5.mol

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Alclometasone Property

Melting point:: 176-179°
alpha: D26 +47.5° (c = 0.3 in DMF)
Boiling point:: 607.1±55.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
pka: 12.30±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C369475
Product name: 7α-Chloro-16α-methylPrednisolone
Packaging: 25mg
Price: $1980
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005896
Product name: ALCLOMETASONE
Purity: 95.00%
Packaging: 10MG
Price: $15303.75
Updated: 2021/12/16

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Alclometasone Chemical Properties,Usage,Production

Uses

A metabolite of Alclometasone dipropionate (A514580); a synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.

Uses

As a metabolite of Alclometasone dipropionate; Alclometasone can be used as a synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.

Definition

ChEBI: A prednisolone compound having an alpha-chloro substituent at the 7-position and an alpha-methyl substituent at the 16-position.

brand name

Aclovate (GlaxoSmithKline).

in vivo

The prodrug of alclometasone is alclometasone dipropionate^[2].Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice^[2].

Alclometasone Preparation Products And Raw materials

Raw materials

Preparation Products

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Alclometasone Suppliers

Canada 1 China 20 United States 4 Global 25

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67452-97-5, AlclometasoneRelated Search:

Mometasone 5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol Formoterol Clobetasol propionate Tamoxifen Clomifene Fluorometholone BECLOMETHASONE Acarbose Methylprednisolone Prednisolone Dexamethasone Alclometasone Alclometasone Dipropionate

ALCLOMETHASONE DIPROPIONATE

7α-Chloro-16α-methylprednisolone

7α-Chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione

Alclometasone

Vaderm

(7α,11β,16α)-7-Chloro-11,17,21-trihydroxy-16-Methylpregna-1,4-diene-3,20-dione

AlcloMethasone

Pregna-1,4-diene-3,20-dione, 7-chloro-11,17,21-trihydroxy-16-methyl-, (7α,11β,16α)-

7α-Chloro-16α-methyl Prednisolone

67452-97-5

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Metabolites & Impurities

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