ChemicalBook > CAS DataBase List > 2-amino-5-nitrobenzyl alcohol

2-amino-5-nitrobenzyl alcohol

Product Name
2-amino-5-nitrobenzyl alcohol
CAS No.
77242-30-9
Chemical Name
2-amino-5-nitrobenzyl alcohol
Synonyms
2-amino-5-nitrobenzyl alcohol;2-Amino-5-nitrobenzenemethanol;Benzenemethanol,2-amino-5-nitro-
CBNumber
CB5895579
Molecular Formula
C7H8N2O3
Formula Weight
168.15
MOL File
77242-30-9.mol
More
Less

2-amino-5-nitrobenzyl alcohol Property

Boiling point:
427.3±30.0 °C(Predicted)
Density 
1.432±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
13.67±0.10(Predicted)
Appearance
Light brown to green Solid
More
Less

Safety

HS Code 
2922190090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TRC
Product number
A578470
Product name
(2-Amino-5-nitrophenyl)methanol
Packaging
250mg
Price
$110
Updated
2021/12/16
TRC
Product number
A578470
Product name
(2-Amino-5-nitrophenyl)methanol
Packaging
500mg
Price
$180
Updated
2021/12/16
AK Scientific
Product number
0808BB
Product name
2-Amino-5-nitrobenzylalcohol
Packaging
5g
Price
$937
Updated
2021/12/16
Anichem
Product number
CT2989
Product name
(2-AMINO-5-NITROPHENYL)METHANOL
Purity
>95%
Packaging
1g
Price
$160
Updated
2021/12/16
Chemcia Scientific
Product number
CC00-9432
Product name
(2-Amino-5-nitro-phenyl)-methanol
Purity
＞97%
Packaging
1g
Price
$175
Updated
2021/12/16
More
Less

2-amino-5-nitrobenzyl alcohol Chemical Properties,Usage,Production

Uses

(2-Amino-5-nitrophenyl)methanol is used in preparation of Spiropyridooxazinepyrrolidine compounds as dual inhibitors of factor XIa and plasma kallikrein.

Synthesis

616-79-5

77242-30-9

General procedure for the synthesis of (2-amino-5-nitrophenyl)methanol from 2-amino-5-nitrobenzoic acid: firstly, compound 24a was prepared from compound 23b according to the literature methodology. after completion of the reaction, the target product 29b was obtained by conventional post-treatment in 92% yield and the product was a butter-like solid. The product was identified by infrared spectroscopy (IR) and the main absorption peaks were located at 3365, 2918, 1612, 1528, 1345, 1239, 1051, 755 cm-1. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, CDCl3) showed δ : 1.27-1.35 (1H, m), 2.11 (1H, dt, J = 5.3, 12.8 Hz), 2.25 (1H, dt, J = 2.8, 12.0 Hz), 2.36-2.48 (1H, m), 2.43 (3H, s), 2.90-3.00 (2H, m), 2.96 (1H, d, J = 18.0 Hz), 3.10 (1H, d, J = 18.0 Hz), 3.27 (1H, d, J = 7.61 (1H, dd, J = 2.0, 9.6 Hz), 7.67 (1H, s), 8.29 (1H, d, J = 2.0 Hz), two protons (OH) were not observed. The nuclear magnetic resonance carbon spectrum (13C NMR, 100 MHz, CDCl3) showed δ: 23.9, 35.8, 36.1, 39.1, 40.4, 42.9, 45.3, 61.4, 69.2, 112.6, 115.0, 121.7, 123.3, 125.6, 127.0, 128.3, 129.2, 131.0, 137.2, 140.3, 144.4, 147.0, 155.2, 162.0. High-resolution mass spectrometry (HRMS, ESI) analysis showed calculated value of C24H24N3O4 [M + H]+: 418.1767, measured value: 418.1748.

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 19, p. 5810 - 5831
[2] Patent: US2014/121415, 2014, A1. Location in patent: Paragraph 0050
[3] Patent: US2010/63037, 2010, A1. Location in patent: Page/Page column 20
[4] Journal of Organic Chemistry, 2010, vol. 75, # 20, p. 7033 - 7036
[5] Patent: WO2015/164308, 2015, A1

2-amino-5-nitrobenzyl alcohol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-amino-5-nitrobenzyl alcohol Suppliers

China 39 India 1 South Korea 1 United States 1 Global 42
Zhengzhou Converging Chemical Co. LTD
Tel
0371-53399770 18037166334
Email
2853031800@qq.com
Country
China
ProdList
5873
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4987
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
Advantage
55
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9126
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Yantai ShengKailun Chemical Technology Co., Ltd.
Tel
13356901049
Fax
QQ：1025383091
Email
3119594100@qq.com
Country
China
ProdList
7964
Advantage
55
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
9713
Advantage
58

77242-30-9, 2-amino-5-nitrobenzyl alcoholRelated Search:

DIRECT BLACK 91 3-NITRO-2,6-DIPIPERIDINOBENZOIC ACID 5-NITROISATOIC ANHYDRIDE 2-(ACETYLAMINO)-5-NITROBENZOIC ACID 2,5-DINITROBENZOIC ACID 2-Amino-5-nitrobenzoic acid METHYL 2-AMINO-5-NITROBENZOATE METHYL 2-MORPHOLINO-5-NITROBENZENECARBOXYLATE 2-MORPHOLINO-5-NITROBENZOIC ACID 5-NITRO-2-(2,6-DIMETHYLMORPHOLIN-4-YL)BENZOIC ACID SPECS AC-907/25004921 AKOS AUF02022 2-AMINO-5-NITROBENZOIC ACID POTASSIUM SALT METHYL 2-(ACETYLAMINO)-5-NITROBENZOATE NPPB

  • 2-amino-5-nitrobenzyl alcohol
  • 2-Amino-5-nitrobenzenemethanol
  • Benzenemethanol,2-amino-5-nitro-
  • 77242-30-9