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cinmetacin

Product Name
cinmetacin
CAS No.
20168-99-4
Chemical Name
cinmetacin
Synonyms
Cindomet;Indolacin;cinmetacin;cinmethacin;cinmetacin USP/EP/BP;5-Methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)-1H-indole-3-acetic acid;1-(1-Oxo-3-phenyl-2-propenyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid;1H-Indole-3-acetic acid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-
CBNumber
CB5899153
Molecular Formula
C21H19NO4
Formula Weight
349.38
MOL File
20168-99-4.mol
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cinmetacin Property

Melting point:
170-172°; mp 164-165°
Boiling point:
483.57°C (rough estimate)
Density 
1.2520 (rough estimate)
refractive index 
1.5614 (estimate)
pka
4.00±0.30(Predicted)
Water Solubility 
<1mg/L(25 ºC)
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Safety

Toxicity
LD50 in mice, rats (mg/kg): 360, 590 i.p.; 750, 1020 orally (Komatsu)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0011034
Product name
CINMETACIN
Purity
95.00%
Packaging
5MG
Price
$496.2
Updated
2021/12/16
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cinmetacin Chemical Properties,Usage,Production

Originator

Cindomet,Chiesi

Definition

ChEBI: Cinmetacin is a member of indole-3-acetic acids.

Manufacturing Process

6.0 g of cinnamoyl chloride was dropwise added to a mixture of 8.7 g of pmethoxyphenylhydrazine hydrochloride, 10.1 g of triethylamine and 200 ml of toluene under cooling at -5° to 0°C. The reaction mixture was stirred at 20°- 25°C for 1 h. The separated precipitates were filtered off and dry gaseous hydrogen chloride was introduced into the filtrate. As a result a large amount of crystals of N1-cinnamoyl-N1-(p-methoxyphenyl)hydrazine hydrochloride were produced. These crystals were collected by filtration and washed with 20 ml of ether and dried to yield N1-cinnamoyl-N1-(p-methoxyphenyl)hydrazine hydrochloride of melting point 183°-185°C.
A mixture of N1-cinnamoyl-N1-(p-methoxyphenyl)hydrazine hydrochloride and
acetonylmalonic acid was heated in acetic acid at heating with stirring. Thereafter, the reaction mixture was allowed to cool, and was poured into cold water, and then crystals were produced. They were collected by filtration, and dried to give crude product. The recrystallization from acetone-water gave fine white needle crystals of 1-cinnamoyl-2-methyl-5-methoxy-3-indolylacetic acid, melting point 164°-165°C.

Therapeutic Function

Antiinflammatory

cinmetacin Preparation Products And Raw materials

Raw materials

Preparation Products

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cinmetacin Suppliers

Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652,+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52849
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
22883
Advantage
58
PT CHEM GROUP LIMITED
Tel
Email
peter68@ptchemgroup.com
Country
China
ProdList
35425
Advantage
58
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View Lastest Price from cinmetacin manufacturers

Dideu Industries Group Limited
Product
cinmetacin 20168-99-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-15

20168-99-4, cinmetacin Related Search:


  • cinmetacin
  • Indolacin
  • cinmethacin
  • 1-(1-Oxo-3-phenyl-2-propenyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
  • 5-Methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)-1H-indole-3-acetic acid
  • Cindomet
  • 1H-Indole-3-acetic acid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-
  • cinmetacin USP/EP/BP
  • 20168-99-4