Melperone hydrochloride

Product Name: Melperone hydrochloride
CAS No.: 1622-79-3
Chemical Name: Melperone hydrochloride
Synonyms: Melperone HCl;Melperone-d4 HCl;MELPERONE HYDROCHLORIDE;Methylperone hydrochloride;1(4-Fluorophenol)-4-(4-methyl-1-piperidinyl)-1-butanone;1-[3-(p-fluorobenzoyl)propyl]-4-methylpiperazinium chloride;1-(4-Fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one HCl;1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanonehydrochloride;1-(4-Fluorophenyl)-4-(4-Methylpiperidin-1-yl)butan-1-one hydrochloride;1-Butanone, 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-, hydrochloride (1:1)
CBNumber: CB5900763
Molecular Formula: C15H22ClFN2O
Formula Weight: 300.7993832
MOL File: 1622-79-3.mol

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Melperone hydrochloride Property

Melting point:: 209-211℃
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Light Brown

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Safety

Toxicity: LD50 in rats, mice (mg/kg): 330, 230 orally; 40, 35 i.v. (Christensen)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19770
Product name: Melperone (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19770
Product name: Melperone (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 19770
Product name: Melperone (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 19770
Product name: Melperone (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $178
Updated: 2024/03/01

Tocris

Product number: 2495
Product name: Melperonehydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $305
Updated: 2021/12/16

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Melperone hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Eunerpan,Nordmark,W. Germany,1965

Uses

Melperone Hydrochloride is an atypical antipsychotic drug.

Uses

Melperone hydrochloride is a neuroleptic butyrophenone. Melperone is also an antiarrhythmic agent. Melperone is an effective atypical antipsychotic drug used in the treatment of schizophrenia.

Manufacturing Process

A solution or dispersion consisting of 20.1 g (0.1 mol) of γ-chloro-pfluorobutyrophenone, 19.8 g (0.2 mol) of 4-methylpiperidine and 0.1 g of potassium iodide in 150 ml toluene is heated in a sealed glass tube for 15 hours at 100°C to 110°C. The potassium iodide and the 4-methylpiperidine hydrochloride formed in the reaction are separated by filtration and the solvent removed from the filtrate by evaporation in vacuum on a steam bath. The residue is distilled and the fraction obtained at 120°C to 125°C and at a pressure lower than 0.1 mm Hg is collected. The base is dissolved in ether and the 4-fluoro-γ-(4-methylpiperidino)-butyrophenone precipitated as the hydrochloride. The reaction product is purified by recrystallization in ethanol/ether.
Yield 22.0 g (73% of theory). MP 209°C to 211°C.

Therapeutic Function

Neuroleptic

Biological Activity

Atypical neuroleptic; 5-HT 2A /D 2 receptor antagonist (K i values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α 1 and α 2 receptors (K i values are 180 and 150 nM respectively).

Safety Profile

Poison by ingestion, subcutaneous, and intravenous routes. Experimental teratogenic effects. A neuroleptic drug used to treat anxiety and confusion. When heated to decomposition it emits very toxic fumes of F-, NOx, and HCl.

Melperone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Melperone hydrochloride Suppliers

Canada 1 China 34 Europe 1 Germany 1 India 6 United Kingdom 1 United States 11 Global 55

Beijing Yisiyan Technology Research Center

Tel: 010-56645598 13366904824
Fax: 01062230033
Email: bjkaida@163.com
Country: China
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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
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Country: China
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3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
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Country: China
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Chembest Research Laboratories Limited

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Country: China
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Chemsky（shanghai）International Co.,Ltd.

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Email: shchemsky@sina.com
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BOC Sciences

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Country: United States
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Shanghai T&W Pharmaceutical Co., Ltd.

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Country: China
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Clearsynth Labs Limited

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DKMbiochem.Co. Ltd

Tel: 15901859516
Fax: 15901859516
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Country: China
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EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
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1622-79-3, Melperone hydrochlorideRelated Search:

4-Fluorophenol Pipamperone Haloperidine TRIFLUPERIDOL HCL Cloroperone Melperone hydrochloride 8-[4-(4-FLUOROPHENYL)-4-OXOBUTYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE HYDROCHLORIDE clofluperol Amiperone 4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE N-(P-ISOTHIOCYANATOPHENETHYL)SPIPERONE HYDROCHLORIDE HALOPERIDOL-D4 HALOPERIDOL, [3H(G)]- Haloperidol N-METHYL-8-[4-(4-FLUOROPHENYL)-4-OXOBUTYL]-1-PHENYL-1,3,8-TRIAZASPIRO-[4.5]DECAN-4-ONE HYDROCHLORIDE

1-[3-(p-fluorobenzoyl)propyl]-4-methylpiperazinium chloride

1(4-Fluorophenol)-4-(4-methyl-1-piperidinyl)-1-butanone

1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanonehydrochloride

1-(4-Fluorophenyl)-4-(4-Methylpiperidin-1-yl)butan-1-one hydrochloride

Melperone-d4 HCl

Methylperone hydrochloride

Melperone HCl

MELPERONE HYDROCHLORIDE

1-Butanone, 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-, hydrochloride (1:1)

1-(4-Fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one HCl

1622-79-3

C16H22FNOHCl

C16H23ClFNO