viomycin
- Product Name
- viomycin
- CAS No.
- 32988-50-4
- Chemical Name
- viomycin
- Synonyms
- Viocin;viomycin;Vioactane;Coliomycin;FLORIMYCIN;Vinacetin A;Tuberactinomycin B;viomycin USP/EP/BP;Glycine, 3-amino-N-[(3S)-3,6-diamino-1-oxohexyl]-L-alanyl-L-seryl-L-seryl-(2Z)-3-[(aminocarbonyl)amino]-2,3-didehydroalanyl-2-[(4R,6S)-2-amino-1,4,5,6-tetrahydro-6-hydroxy-4-pyrimidinyl]-, (5→13)-lactam, (2S)-;(S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamidedisulfate
- CBNumber
- CB5910382
- Molecular Formula
- C25H43N13O10
- Formula Weight
- 685.7
- MOL File
- 32988-50-4.mol
viomycin Property
- Melting point:
- 280 °C
- Boiling point:
- 695.81°C (rough estimate)
- Density
- 1.3613 (rough estimate)
- refractive index
- 1.6700 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Water (Slightly)
- form
- Powder
- pka
- pKa 8.2 (Uncertain);10.3 (Uncertain)
- Water Solubility
- Soluble to 75 mM in water
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 3787
- Product name
- Viomycin
- Packaging
- 10
- Price
- $182
- Updated
- 2021/12/16
- Product number
- A8645
- Product name
- Viomycin
- Packaging
- 10mg
- Price
- $274
- Updated
- 2021/12/16
- Product number
- API0009965
- Product name
- VIOMYCIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.54
- Updated
- 2021/12/16
viomycin Chemical Properties,Usage,Production
Description
Viomycin was found independently in 1951, in the culture broth of Streptomyces puniceus by Pfizer Research Laboratories and in that of S. floridae by Parke Davis Co. It shows strong activity against Mycobacterium species and moderate activity against gram-positive and gram-negative bacteria. Viomycin has been used by intramuscular administration to treat tuberculosis, but because of its ototoxicity and renal toxicity it is being replaced by more active and less toxic drugs, such as enviomycin and other antituberculotic antibiotics.
Originator
Vinactane,Ciba,US ,1953
Uses
Viomycin is a basic peptide antibiotic, which is an effective agent against multidrug-resistant tuberculosis.
Definition
ChEBI: A cyclic peptide antibiotic produced by the actinomycete Streptomyces puniceus, used in the treatment of tuberculosis.
Indications
Viomycin is a complex polypeptide antibiotic that is active against MDR strains of tuberculosis. Cross-resistance between viomycin and kanamycin is less frequent than between viomycin and capreomycin.
Manufacturing Process
Viomycin is produced by inoculating a nutrient medium with a viable strain of the organism Actinomyces vinaceus. A method for the production of viomycin is set forth in US Patent 2,663,445 comprising inoculating a medium containing soy peptone, beef extract, dextrose, sodium chloride and a silicone antifoaming agent with a spore suspension of Actinomyces vinaceus and incubating the inoculated medium for 120 hours at a temperature of 26°C while passing sterile air through the medium at a rate of 500 ml per liter of medium per minute.
brand name
Viocin Sulfate (Pfizer).
Therapeutic Function
Antitubercular
Biological Activity
Member of the tuberactinomycin family of antibiotics . Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans -cleavage of the Neurospora VS ribozyme.
viomycin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from viomycin manufacturers
- Product
- viomycin 32988-50-4
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-07
- Product
- viomycin 32988-50-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-22