8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
- Product Name
- 8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
- CAS No.
- 22316-55-8
- Chemical Name
- 8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
- Synonyms
- Clofazin;Norclobazam;Einecs 244-909-2;Demethylclobazam;Desmethylclobazam;N-Demethylclobazam;Clobazam EP Impurity A;N-Desmethylclobazam (CRM);Clobazam Related Compound A;N-Desmethylclobazam solution
- CBNumber
- CB5921872
- Molecular Formula
- C15H11ClN2O2
- Formula Weight
- 286.71
- MOL File
- 22316-55-8.mol
8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Property
- Melting point:
- >239°C (dec.)
- Boiling point:
- 601.8±55.0 °C(Predicted)
- Density
- 1.363±0.06 g/cm3(Predicted)
- Flash point:
- 2℃
- storage temp.
- Controlled Substance, -20°C Freezer
- solubility
- Acetonitrile (Soluble)
- pka
- 7.57±0.20(Predicted)
- form
- A neat solid
Safety
- Hazard Codes
- F,Xn
- Risk Statements
- 11-20/21/22-36
- Safety Statements
- 16-36/37
- RIDADR
- UN 1648 3 / PGII
- WGK Germany
- 2
- Toxicity
- mouse,LD50,oral,> 2583mg/kg (2583mg/kg),United States Patent Document. Vol. #3760074,
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D-145
- Product name
- N-Desmethylclobazam solution
- Purity
- 1.0?mg/mL (acetonitrile:DMSO (90:10 v/v)), ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1ML
- Price
- $428
- Updated
- 2024/03/01
- Product number
- D-049
- Product name
- N-Desmethylclobazam solution
- Purity
- 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $219
- Updated
- 2024/03/01
- Product number
- 18564
- Product name
- N-Desmethylclobazam
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 18564
- Product name
- N-Desmethylclobazam
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $355
- Updated
- 2024/03/01
- Product number
- 18888
- Product name
- N-Desmethylclobazam (CRM)
- Packaging
- 100μg
- Price
- $119
- Updated
- 2024/03/01
8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Chemical Properties,Usage,Production
Description
N-Desmethylclobazam (Item No. 18564) is an analytical reference material that is structurally categorized as a benzodiazepine. It is a major active metabolite of clobazam, produced primarily by the action of cytochrome P450 isoform 3A4. N-Desmethylclobazam positively modulates GABAA receptors (EC50s range from 98 to 151 μM, depending on subunit configuration). This product is intended for research and forensic applications.
Description
N-Desmethylclobazam (CRM) (Item No. 18888) is a certified reference material that is structurally categorized as a benzodiazepine. It is a major active metabolite of clobazam, produced primarily by the action of cytochrome P450 isoform 3A4. N-Desmethylclobazam (CRM) positively modulates GABAA receptors (EC50s range from 98 to 151 μM, depending on subunit configuration). This product is intended for research and forensic applications.
Chemical Properties
Off-White Solid
Uses
The major metabolite of Clobazam Controlled substance (depressant).
Definition
ChEBI: N-Desmethylclobazam is a benzodiazepine.
General Description
A Certified Solution Standard for use in LC or GC applications from forensic and forensic toxicology analysis to urine drug testing. N-Desmethylclobazam, found in urine, serum, and plasma, is the pharmacologically active, major metabolite of clobazam.
8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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