8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Property

Melting point:

>239°C (dec.)

Boiling point:

601.8±55.0 °C(Predicted)

Density 

1.363±0.06 g/cm3(Predicted)

Flash point:

2℃

storage temp. 

Controlled Substance, -20°C Freezer

solubility 

Acetonitrile (Soluble)

pka

7.57±0.20(Predicted)

form 

A neat solid

Safety

Hazard Codes 

F,Xn

Risk Statements 

11-20/21/22-36

Safety Statements 

16-36/37

RIDADR 

UN 1648 3 / PGII

WGK Germany 

2

Toxicity

mouse,LD50,oral,> 2583mg/kg (2583mg/kg),United States Patent Document. Vol. #3760074,

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Chemical Properties,Usage,Production

Description

N-Desmethylclobazam (Item No. 18564) is an analytical reference material that is structurally categorized as a benzodiazepine. It is a major active metabolite of clobazam, produced primarily by the action of cytochrome P450 isoform 3A4. N-Desmethylclobazam positively modulates GABA_A receptors (EC₅₀s range from 98 to 151 μM, depending on subunit configuration). This product is intended for research and forensic applications.

Description

N-Desmethylclobazam (CRM) (Item No. 18888) is a certified reference material that is structurally categorized as a benzodiazepine. It is a major active metabolite of clobazam, produced primarily by the action of cytochrome P450 isoform 3A4. N-Desmethylclobazam (CRM) positively modulates GABA_A receptors (EC₅₀s range from 98 to 151 μM, depending on subunit configuration). This product is intended for research and forensic applications.

Chemical Properties

Off-White Solid

Uses

The major metabolite of Clobazam Controlled substance (depressant).

Definition

ChEBI: N-Desmethylclobazam is a benzodiazepine.

General Description

A Certified Solution Standard for use in LC or GC applications from forensic and forensic toxicology analysis to urine drug testing. N-Desmethylclobazam, found in urine, serum, and plasma, is the pharmacologically active, major metabolite of clobazam.