N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride

Product Name: N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride
CAS No.: 4784-40-1
Chemical Name: N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride
Synonyms: Ao Suoma hydrochloride;Oxomemazine hydrochloride;Oxomemazine·hydrochloric acid;N,N,β-Trimethyl-[10H]-phenothiazine-10-propanamine 5,5-dioxide hydrochloride;10-(3-(dimethylamino)-2-methylpropyl)-10H-phenothiazine 5,5-dioxide hydrochloride;N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride
CBNumber: CB5925092
Molecular Formula: C18H23ClN2O2S
Formula Weight: 366.9
MOL File: 4784-40-1.mol

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N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride Property

InChI: InChI=1S/C18H22N2O2S.ClH/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)23(21,22)18-11-7-5-9-16(18)20;/h4-11,14H,12-13H2,1-3H3;1H
InChIKey: NPMMOYKGIWLASW-UHFFFAOYSA-N
SMILES: C(N1C2=CC=CC=C2S(=O)(=O)C2C=CC=CC1=2)C(C)CN(C)C.Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0009065
Product name: METHDILAZINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 50MG
Price: $697.34
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009065
Product name: METHDILAZINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 500MG
Price: $1758.49
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009065
Product name: METHDILAZINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $2355.15
Updated: 2021/12/16

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N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride Chemical Properties,Usage,Production

Originator

Doxergan,Specia,France,1964

Uses

Oxomemazine hydrochloride is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine hydrochloride is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki= 84 nM, M1 receptor) and low (Ki= 1.65 μM, M2 receptor) affinity sites[1]. Oxomemazine hydrochloride an antihistamine and anticholinergic agent used for the study of cough treatment[2].

Manufacturing Process

Phenothiazine is reacted with 3-dimethylamino-2-methylpropyl chloride in the presence of sodium amide to give 3-(10-phenthiazinyl)-2-methyl-1dimethylaminopropane. 11.9 g of of this intermediate is dissolved with agitation in glacial acetic acid (120 cc). Pure sulfuric acid (d = 1.83; 0.5 cc) is added and a mixture of glacial acetic acid (10 cc) and hydrogen peroxide (8.5 cc of a solution containing 38 g of hydrogen peroxide in 100 cc) is then run in over 20 minutes. The temperature rises from 25°C to 35°C and is then kept at 60°C for 18 hours. The mixture is cooled and water (150 cc) is added and, with cooling, aqueous sodium hydroxide (d = 1.33; 220 cc). The resulting mixture is extracted with ethyl acetate (3 x 100 cc), the solvent is evaporated on a water bath and the residue is recrystallized from heptane (150 cc). 3(9,9-dioxy-10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (78 g) is obtained, MP 115°C.
The corresponding hydrochloride prepared in ethyl acetate and recrystallized from a mixture of ethanol and isopropanol melts at 250°C.

Therapeutic Function

Antihistaminic

IC 50

mGluR 1: 84 nM (Ki); mGluR2: 1.65 μM (Ki)

References

[1] S W Lee, et al.Selectivity of oxomemazine for the M1 muscarinic receptors.Arch Pharm Res. 1994 Dec;17(6):443-51. DOI:10.1007/BF02979123
[2] M S Siddegowda, et al.Oxomemazine hydro-chloride. Acta Crystallogr Sect E Struct Rep Online. 2011 Aug 1;67(Pt 8):o1875. DOI:10.1107/S1600536811025372

N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride Suppliers

China 21 India 6 United States 2 Global 29

Jiangsu Magic Biotechnology Co., Ltd

Tel: 13921770081
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Shanghai HuanChuan Industry Co.,Ltd.

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Xi'an MC Biotech, Co., Ltd.

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Baoji Guokang Healthchem Co., Ltd.

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Hefei fuya biotechnology co. LTD

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View Lastest Price from N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride manufacturers

Baoji Guokang Healthchem Co., Ltd.

Product: N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride 4784-40-1
Price: US $6780.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1-100kg
Release date: 2021-06-04

Shaanxi Dideu Medichem Co. Ltd

Product: Oxomemazine Hydrochloride 4784-40-1
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-07-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride 4784-40-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

4784-40-1, N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochlorideRelated Search:

OXOMEMAZINE

N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride

N,N,β-Trimethyl-[10H]-phenothiazine-10-propanamine 5,5-dioxide hydrochloride

Oxomemazine hydrochloride

Oxomemazine·hydrochloric acid

Ao Suoma hydrochloride

10-(3-(dimethylamino)-2-methylpropyl)-10H-phenothiazine 5,5-dioxide hydrochloride

4784-40-1