OXOMEMAZINE
- Product Name
- OXOMEMAZINE
- CAS No.
- 3689-50-7
- Chemical Name
- OXOMEMAZINE
- Synonyms
- Imakol;6847 RP;6487 RP;Dysedon;RP-6847;Doxergan;Dosegran;6847 R.P.;Oxomemazin;OXOEMAZINE
- CBNumber
- CB1236273
- Molecular Formula
- C18H22N2O2S
- Formula Weight
- 330.44
- MOL File
- 3689-50-7.mol
OXOMEMAZINE Property
- Melting point:
- 115°
- Boiling point:
- 492.4±34.0 °C(Predicted)
- Density
- 1.1453 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Store at -20°C
- solubility
- ≥ 33mg/mL in DMSO
- form
- Solid
- pka
- 9.31±0.28(Predicted)
- color
- White to off-white
Safety
- Toxicity
- LD50 oral in mouse: 140mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H330Fatal if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P310Immediately call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- O860005
- Product name
- (±)-Oxomemazine
- Packaging
- 1g
- Price
- $920
- Updated
- 2021/12/16
- Product number
- API0009875
- Product name
- OXOMEMAZINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $892.5
- Updated
- 2021/12/16
- Product number
- CS-0131898
- Product name
- Oxomemazine
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- API0009875
- Product name
- OXOMEMAZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.11
- Updated
- 2021/12/16
- Product number
- CD11134460
- Product name
- Oxomemazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $680
- Updated
- 2021/12/16
OXOMEMAZINE Chemical Properties,Usage,Production
Originator
Doxergan,Specia,France,1964
Uses
(±)-Oxomemazine, is a phenothiazine-type antihistamines, that has also shown antibacterial activity against Mycobacterium tuberculosis.
Definition
ChEBI: Oxomemazine is a member of phenothiazines.
Manufacturing Process
Phenothiazine is reacted with 3-dimethylamino-2-methylpropyl chloride in the presence of sodium amide to give 3-(10-phenthiazinyl)-2-methyl-1dimethylaminopropane. 11.9 g of of this intermediate is dissolved with agitation in glacial acetic acid (120 cc). Pure sulfuric acid (d = 1.83; 0.5 cc) is added and a mixture of glacial acetic acid (10 cc) and hydrogen peroxide (8.5 cc of a solution containing 38 g of hydrogen peroxide in 100 cc) is then run in over 20 minutes. The temperature rises from 25°C to 35°C and is then kept at 60°C for 18 hours. The mixture is cooled and water (150 cc) is added and, with cooling, aqueous sodium hydroxide (d = 1.33; 220 cc). The resulting
mixture is extracted with ethyl acetate (3 x 100 cc), the solvent is evaporated on a water bath and the residue is recrystallized from heptane (150 cc). 3(9,9-dioxy-10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (78 g) is obtained, MP 115°C.
The corresponding hydrochloride prepared in ethyl acetate and recrystallized from a mixture of ethanol and isopropanol melts at 250°C.
Therapeutic Function
Antihistaminic
OXOMEMAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
OXOMEMAZINE Suppliers
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View Lastest Price from OXOMEMAZINE manufacturers
- Product
- Oxomemazine 3689-50-7
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg/Month
- Release date
- 2022-11-23
- Product
- Oxomemazine 3689-50-7
- Price
- US $100.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 1000g
- Release date
- 2023-03-10