OXOMEMAZINE
- Product Name
- OXOMEMAZINE
- CAS No.
- 3689-50-7
- Chemical Name
- OXOMEMAZINE
- Synonyms
- Imakol;6847 RP;6487 RP;Dysedon;RP-6847;Doxergan;Dosegran;6847 R.P.;Oxomemazin;OXOEMAZINE
- CBNumber
- CB1236273
- Molecular Formula
- C18H22N2O2S
- Formula Weight
- 330.44
- MOL File
- 3689-50-7.mol
OXOMEMAZINE Property
- Melting point:
- 115°
- Boiling point:
- 492.4±34.0 °C(Predicted)
- Density
- 1.1453 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Store at -20°C
- solubility
- ≥ 33mg/mL in DMSO
- form
- Solid
- pka
- 9.31±0.28(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C18H22N2O2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)23(21,22)18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
- InChIKey
- QTQPVLDZQVPLGV-UHFFFAOYSA-N
- SMILES
- N1(CC(C)CN(C)C)C2C=CC=CC=2S(=O)(=O)C2C=CC=CC1=2
Safety
- Toxicity
- LD50 oral in mouse: 140mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H330Fatal if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P310Immediately call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- O860005
- Product name
- (±)-Oxomemazine
- Packaging
- 1g
- Price
- $920
- Updated
- 2021/12/16
- Product number
- CS-0131898
- Product name
- Oxomemazine
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- API0009875
- Product name
- OXOMEMAZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.11
- Updated
- 2021/12/16
- Product number
- API0009875
- Product name
- OXOMEMAZINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $892.5
- Updated
- 2021/12/16
- Product number
- CD11134460
- Product name
- Oxomemazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $680
- Updated
- 2021/12/16
OXOMEMAZINE Chemical Properties,Usage,Production
Originator
Doxergan,Specia,France,1964
History
The development of oxomemazine is the result of a systematic exploration of phenothiazine compounds in the mid-20th century. Following the significant sedative effects of the first-generation antihistamine promethazine, scientists focused on optimizing its pharmacological properties through structural modification. In the late 1950s and early 1960s, researchers synthesized oxomemazine by chemically modifying the side chains of promethazine. This new compound retained potent antihistamine activity while enhancing its antitussive and sedative effects. Based on these properties, oxomemazine was marketed as an antitussive in the 1960s, often under the brand name Toplexil®, and was particularly suitable for treating allergic dry cough accompanied by sleep disturbances.
Uses
(±)-Oxomemazine, is a phenothiazine-type antihistamines, that has also shown antibacterial activity against Mycobacterium tuberculosis.
Definition
ChEBI: Oxomemazine is a member of phenothiazines.
Manufacturing Process
Phenothiazine is reacted with 3-dimethylamino-2-methylpropyl chloride in the presence of sodium amide to give 3-(10-phenthiazinyl)-2-methyl-1dimethylaminopropane. 11.9 g of of this intermediate is dissolved with agitation in glacial acetic acid (120 cc). Pure sulfuric acid (d = 1.83; 0.5 cc) is added and a mixture of glacial acetic acid (10 cc) and hydrogen peroxide (8.5 cc of a solution containing 38 g of hydrogen peroxide in 100 cc) is then run in over 20 minutes. The temperature rises from 25°C to 35°C and is then kept at 60°C for 18 hours. The mixture is cooled and water (150 cc) is added and, with cooling, aqueous sodium hydroxide (d = 1.33; 220 cc). The resulting
mixture is extracted with ethyl acetate (3 x 100 cc), the solvent is evaporated on a water bath and the residue is recrystallized from heptane (150 cc). 3(9,9-dioxy-10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (78 g) is obtained, MP 115°C.
The corresponding hydrochloride prepared in ethyl acetate and recrystallized from a mixture of ethanol and isopropanol melts at 250°C.
Therapeutic Function
Antihistaminic
OXOMEMAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from OXOMEMAZINE manufacturers
- Product
- OXOMEMAZINE 3689-50-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-11-26
- Product
- Oxomemazine 3689-50-7
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg/Month
- Release date
- 2022-11-23
- Product
- Oxomemazine 3689-50-7
- Price
- US $100.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 1000g
- Release date
- 2023-03-10