Trimeprazine
- Product Name
- Trimeprazine
- CAS No.
- 84-96-8
- Chemical Name
- Trimeprazine
- Synonyms
- Teralen;Teralene;Alimezine;Bayer 1219;ALIMENAZINE;alimemazine;TRIMEPRAZINE;Trimeperazine;dl-Trimeprazine;Methylpromazine
- CBNumber
- CB0146078
- Molecular Formula
- C18H22N2S
- Formula Weight
- 298.45
- MOL File
- 84-96-8.mol
Trimeprazine Property
- Melting point:
- 68°C
- Boiling point:
- bp0.3 150-175°
- Density
- 1.1163 (rough estimate)
- refractive index
- 1.6000 (estimate)
- pka
- pKa 9.00 (Uncertain)
- Water Solubility
- 0.942 mg/L
- CAS DataBase Reference
- 84-96-8
- NIST Chemistry Reference
- Trimeprazine(84-96-8)
Safety
- Hazardous Substances Data
- 84-96-8(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H317May cause an allergic skin reaction
H318Causes serious eye damage
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- API0009048
- Product name
- TRIMEPRAZINE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $2122.31
- Updated
- 2021/12/16
- Product number
- T-7860
- Product name
- Trimeprazine-d6(Alimemazine-d6)HCl
- Packaging
- 10mg
- Price
- $1800
- Updated
- 2021/12/16
Trimeprazine Chemical Properties,Usage,Production
Originator
Temaril,SKF,US,1958
Uses
antipruritic
Uses
Trimeprazine is used for treating itching during dermatitis of both allergic and nonallergic origin.
Definition
ChEBI: Trimeprazine is a member of phenothiazines.
Manufacturing Process
95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6
grams) in xylene (140 cc) at a temperature of 130°C and the mixture is
heated with reflux for 2 hours.
A 0.61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in
xylene is then added over 50 minutes and heating with reflux is continued for
20 hours. After cooling, the mixture is treated with water (40 cc) and N
methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated
with aqueous sodium hydroxide (density = 1.33; 10 cc) and extracted with
ether.
The extract is dried over potassium carbonate and evaporated and the residue
is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane
(12.6 grams) is collected, distilling between 150° and 175°C under a pressure
of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal
hydrogen chloride, a hydrochloride is obtained, MP 216° to 217°C.
brand name
Temaril (Allergan).
Therapeutic Function
Antipruritic
Trimeprazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Trimeprazine manufacturers
- Product
- Trimeprazine 84-96-8
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- Trimeprazine 84-96-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-10