Trimeprazine

Product Name
Trimeprazine
CAS No.
84-96-8
Chemical Name
Trimeprazine
Synonyms
Teralen;Teralene;Alimezine;Bayer 1219;ALIMENAZINE;alimemazine;TRIMEPRAZINE;Trimeperazine;dl-Trimeprazine;Methylpromazine
CBNumber
CB0146078
Molecular Formula
C18H22N2S
Formula Weight
298.45
MOL File
84-96-8.mol
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Trimeprazine Property

Melting point:
68°C
Boiling point:
bp0.3 150-175°
Density 
1.1163 (rough estimate)
refractive index 
1.6000 (estimate)
pka
pKa 9.00 (Uncertain)
Water Solubility 
0.942 mg/L
CAS DataBase Reference
84-96-8
NIST Chemistry Reference
Trimeprazine(84-96-8)
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Safety

Hazardous Substances Data
84-96-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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Trimeprazine Chemical Properties,Usage,Production

Originator

Temaril,SKF,US,1958

Uses

antipruritic

Uses

Trimeprazine is used for treating itching during dermatitis of both allergic and nonallergic origin.

Manufacturing Process

95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6 grams) in xylene (140 cc) at a temperature of 130°C and the mixture is heated with reflux for 2 hours.
A 0.61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in xylene is then added over 50 minutes and heating with reflux is continued for 20 hours. After cooling, the mixture is treated with water (40 cc) and N methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated with aqueous sodium hydroxide (density = 1.33; 10 cc) and extracted with ether.
The extract is dried over potassium carbonate and evaporated and the residue is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (12.6 grams) is collected, distilling between 150° and 175°C under a pressure of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal hydrogen chloride, a hydrochloride is obtained, MP 216° to 217°C.

brand name

Temaril (Allergan).

Therapeutic Function

Antipruritic

Trimeprazine Preparation Products And Raw materials

Raw materials

Preparation Products

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Trimeprazine Suppliers

Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8074
Advantage
58
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791/13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3931
Advantage
50
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Email
mail@meishuichem.com
Country
China
ProdList
4536
Advantage
56
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com
Country
China
ProdList
19252
Advantage
56
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432-
Fax
0571-87396431
Email
sales@jhechem.com;
Country
China
ProdList
13909
Advantage
53
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9804
Advantage
50
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5915
Advantage
50
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Please Email
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9551
Advantage
50
Shanghai TBBMed Co.,Ltd
Tel
021-50498136
Fax
021-50498136
Email
products@tbbmed.com
Country
China
ProdList
955
Advantage
55
Artis Biotech Co. Ltd.
Tel
13918153394 0575-89298960 +91-8849247288
Fax
0575-89298961
Email
sales@artis-standards.com;jkansara@artis-standards.com
Country
China
ProdList
2173
Advantage
58
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View Lastest Price from Trimeprazine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Trimeprazine 84-96-8
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-08

84-96-8, TrimeprazineRelated Search:


  • n,n,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
  • 10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-
  • dl-Trimeprazine
  • Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]- (6CI, 8CI)
  • Teralene
  • ALIMENAZINE
  • Trimeprazine (base and/or unspecified salts)
  • alimemazine
  • 10-[2-Methyl-3-(dimethylamino)propyl]phenothiazine
  • 10-[3-(Dimethylamino)-2-methylpropyl]phenothiazine
  • 10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-
  • Alimezine
  • Bayer 1219
  • Methylpromazine
  • N,N,2-Trimethyl-3-(10H-phenothiazin-10-yl)-1-propanamine
  • Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-
  • Teralen
  • Trimeperazine
  • Alimemazine-d6 MALEATE SALT
  • TRIMEPRAZINE
  • dimethyl-(2-methyl-3-phenothiazin-10-yl-propyl)amine
  • N,N,2-triMethyl-3-(10H-phenothiazin-10-yl)propan-1-aMine
  • 10H-Phenothiazine-10-propanaMine,N,N,b-triMethyl-
  • 84-96-8
  • 84-86-8
  • C18H22N2S
  • TEMARIL