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Trimeprazine

Product Name
Trimeprazine
CAS No.
84-96-8
Chemical Name
Trimeprazine
Synonyms
Teralen;Teralene;Alimezine;Bayer 1219;ALIMENAZINE;alimemazine;TRIMEPRAZINE;Trimeperazine;dl-Trimeprazine;Methylpromazine
CBNumber
CB0146078
Molecular Formula
C18H22N2S
Formula Weight
298.45
MOL File
84-96-8.mol
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Trimeprazine Property

Melting point:
68°C
Boiling point:
bp0.3 150-175°
Density 
1.1163 (rough estimate)
refractive index 
1.6000 (estimate)
pka
pKa 9.00 (Uncertain)
Water Solubility 
0.942 mg/L
CAS DataBase Reference
84-96-8
NIST Chemistry Reference
Trimeprazine(84-96-8)
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Safety

Hazardous Substances Data
84-96-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H318Causes serious eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0009048
Product name
TRIMEPRAZINE
Purity
95.00%
Packaging
25G
Price
$2122.31
Updated
2021/12/16
Chemtos
Product number
T-7860
Product name
Trimeprazine-d6(Alimemazine-d6)HCl
Packaging
10mg
Price
$1800
Updated
2021/12/16
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Trimeprazine Chemical Properties,Usage,Production

Originator

Temaril,SKF,US,1958

Uses

antipruritic

Uses

Trimeprazine is used for treating itching during dermatitis of both allergic and nonallergic origin.

Definition

ChEBI: Trimeprazine is a member of phenothiazines.

Manufacturing Process

95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6 grams) in xylene (140 cc) at a temperature of 130°C and the mixture is heated with reflux for 2 hours.
A 0.61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in xylene is then added over 50 minutes and heating with reflux is continued for 20 hours. After cooling, the mixture is treated with water (40 cc) and N methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated with aqueous sodium hydroxide (density = 1.33; 10 cc) and extracted with ether.
The extract is dried over potassium carbonate and evaporated and the residue is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (12.6 grams) is collected, distilling between 150° and 175°C under a pressure of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal hydrogen chloride, a hydrochloride is obtained, MP 216° to 217°C.

brand name

Temaril (Allergan).

Therapeutic Function

Antipruritic

Trimeprazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Trimeprazine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Trimeprazine 84-96-8
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
Trimeprazine 84-96-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-10
Dideu Industries Group Limited
Product
Trimeprazine 84-96-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-16

84-96-8, TrimeprazineRelated Search:


  • n,n,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
  • 10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-
  • dl-Trimeprazine
  • Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]- (6CI, 8CI)
  • Teralene
  • ALIMENAZINE
  • Trimeprazine (base and/or unspecified salts)
  • alimemazine
  • 10-[2-Methyl-3-(dimethylamino)propyl]phenothiazine
  • 10-[3-(Dimethylamino)-2-methylpropyl]phenothiazine
  • 10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-
  • Alimezine
  • Bayer 1219
  • Methylpromazine
  • N,N,2-Trimethyl-3-(10H-phenothiazin-10-yl)-1-propanamine
  • Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-
  • Teralen
  • Trimeperazine
  • Alimemazine-d6 MALEATE SALT
  • TRIMEPRAZINE
  • dimethyl-(2-methyl-3-phenothiazin-10-yl-propyl)amine
  • N,N,2-triMethyl-3-(10H-phenothiazin-10-yl)propan-1-aMine
  • 10H-Phenothiazine-10-propanaMine,N,N,b-triMethyl-
  • Trimeprazine USP/EP/BP
  • 84-96-8
  • 84-86-8
  • C18H22N2S
  • TEMARIL