MEQUITAZINE
- Product Name
- MEQUITAZINE
- CAS No.
- 29216-28-2
- Chemical Name
- MEQUITAZINE
- Synonyms
- Butix;LM 209;Mircol;MQ-A-88;Vigigan;Zesulan;Instotal;Primalan;Virginan;Nipolazin
- CBNumber
- CB5487473
- Molecular Formula
- C20H22N2S
- Formula Weight
- 322.47
- MOL File
- 29216-28-2.mol
MEQUITAZINE Property
- Melting point:
- 143-145°C
- Boiling point:
- 469.4±24.0 °C(Predicted)
- Density
- 1.1330 (rough estimate)
- refractive index
- 1.5800 (estimate)
- storage temp.
- Refrigerator
- Water Solubility
- Insoluble in water
- solubility
- DMSO : 16 mg/mL (49.62 mM)
- form
- powder to crystal
- pka
- 10.43±0.33(Predicted)
- color
- White to Almost white
- Merck
- 14,5864
- CAS DataBase Reference
- 29216-28-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Mequitazine(29216-28-2)
Safety
- RIDADR
- UN 2811 6.1/PG III
- RTECS
- SP5080000
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M2807
- Product name
- Mequitazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 100mg
- Price
- $69
- Updated
- 2024/03/01
- Product number
- M2807
- Product name
- Mequitazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $208
- Updated
- 2024/03/01
- Product number
- M225110
- Product name
- Mequitazine
- Packaging
- 100mg
- Price
- $485
- Updated
- 2021/12/16
- Product number
- M225110
- Product name
- Mequitazine
- Packaging
- 50g
- Price
- $1090
- Updated
- 2021/12/16
- Product number
- 38078
- Product name
- Mequitazine,≥98%(Assaybytitration,GC)Hazmat
- Purity
- ≥98%(Assaybytitration,GC)
- Packaging
- 100MG
- Price
- $34.94
- Updated
- 2021/12/16
MEQUITAZINE Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Primalan,Berk,UK,1976
Uses
It is an antihistamine
Definition
ChEBI: Mequitazine is a member of phenothiazines.
Manufacturing Process
30 g of phenothiazine were added, all at once, to a suspension of 6 g of sodium amide in 240 ml of anhydrous xylene. The mixture was agitated and heated to reflux. When evolution of ammonia ceased (5 hours), 15 g of 3- chloromethyl-quinuclidine hydrochloride were added portionwise over a period of 50 minutes and reflux was then maintained for 22 hours. After cooling to room temperature, 250 ml of distilled water and 250 ml of ethyl acetate were added to the reaction mixture. The aqueous phase was decanted and extracted twice with a total of 250 ml of methyl acetate. The combined organic extracts were extracted three times with a total of 750 ml of a 10% aqueous solution of tartaric acid. The combined acid solutions were treated with 5 g of animal charcoal, filtered and rendered alkaline on an ice bath with 96 ml of 10 N aqueous caustic soda. The oil which separated was extracted three times with a total of 1.500 ml of ethyl acetate. The combined organic extracts were washed to neutrality by washing twice with a total of 1 liter of distilled water, dried over anhydrous magnesium sulfate and evaporated under reduced pressure on a water bath at 45°C. 17 g of oil were obtained which was purified by chromatography on an inert alumina column. 13.3 g of crystallized product were obtained. 10-(3-Quinuclidinyl-methyl)-phenothiazine having a MP of 130°C to 131°C was obtained by recrystallization in boiling acetonitrile.
The 3-chloromethyl-quinuclidine hydrochloride used as starting material in this process can be obtained as described by Grob and coll., Helv. Chim. Acta, 37 (1954),1689.
Therapeutic Function
Antihistaminic
MEQUITAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from MEQUITAZINE manufacturers
- Product
- Mequitazine 29216-28-2
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 98.5%min
- Supply Ability
- 10kg
- Release date
- 2021-08-05
- Product
- MEQUITAZINE 29216-28-2
- Price
- US $3015.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5kg
- Release date
- 2021-06-04
- Product
- MEQUITAZINE 29216-28-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10