ChemicalBook > CAS DataBase List > MEQUITAZINE

MEQUITAZINE

Product Name
MEQUITAZINE
CAS No.
29216-28-2
Chemical Name
MEQUITAZINE
Synonyms
Butix;LM 209;Mircol;MQ-A-88;Vigigan;Zesulan;Instotal;Primalan;Virginan;Nipolazin
CBNumber
CB5487473
Molecular Formula
C20H22N2S
Formula Weight
322.47
MOL File
29216-28-2.mol
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MEQUITAZINE Property

Melting point:
143-145°C
Boiling point:
469.4±24.0 °C(Predicted)
Density 
1.1330 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Refrigerator
Water Solubility 
Insoluble in water
solubility 
DMSO : 16 mg/mL (49.62 mM)
form 
powder to crystal
pka
10.43±0.33(Predicted)
color 
White to Almost white
Merck 
14,5864
CAS DataBase Reference
29216-28-2(CAS DataBase Reference)
NIST Chemistry Reference
Mequitazine(29216-28-2)
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Safety

RIDADR 
UN 2811 6.1/PG III
RTECS 
SP5080000
HazardClass 
6.1
PackingGroup 
III
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2807
Product name
Mequitazine
Purity
>98.0%(GC)(T)
Packaging
100mg
Price
$69
Updated
2024/03/01
TCI Chemical
Product number
M2807
Product name
Mequitazine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$208
Updated
2024/03/01
TRC
Product number
M225110
Product name
Mequitazine
Packaging
100mg
Price
$485
Updated
2021/12/16
TRC
Product number
M225110
Product name
Mequitazine
Packaging
50g
Price
$1090
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA25075
Product name
10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine
Packaging
25g
Price
$375
Updated
2021/12/16
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MEQUITAZINE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Primalan,Berk,UK,1976

Uses

It is an antihistamine

Definition

ChEBI: Mequitazine is a member of phenothiazines.

Manufacturing Process

30 g of phenothiazine were added, all at once, to a suspension of 6 g of sodium amide in 240 ml of anhydrous xylene. The mixture was agitated and heated to reflux. When evolution of ammonia ceased (5 hours), 15 g of 3- chloromethyl-quinuclidine hydrochloride were added portionwise over a period of 50 minutes and reflux was then maintained for 22 hours. After cooling to room temperature, 250 ml of distilled water and 250 ml of ethyl acetate were added to the reaction mixture. The aqueous phase was decanted and extracted twice with a total of 250 ml of methyl acetate. The combined organic extracts were extracted three times with a total of 750 ml of a 10% aqueous solution of tartaric acid. The combined acid solutions were treated with 5 g of animal charcoal, filtered and rendered alkaline on an ice bath with 96 ml of 10 N aqueous caustic soda. The oil which separated was extracted three times with a total of 1.500 ml of ethyl acetate. The combined organic extracts were washed to neutrality by washing twice with a total of 1 liter of distilled water, dried over anhydrous magnesium sulfate and evaporated under reduced pressure on a water bath at 45°C. 17 g of oil were obtained which was purified by chromatography on an inert alumina column. 13.3 g of crystallized product were obtained. 10-(3-Quinuclidinyl-methyl)-phenothiazine having a MP of 130°C to 131°C was obtained by recrystallization in boiling acetonitrile.
The 3-chloromethyl-quinuclidine hydrochloride used as starting material in this process can be obtained as described by Grob and coll., Helv. Chim. Acta, 37 (1954),1689.

Therapeutic Function

Antihistaminic

MEQUITAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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MEQUITAZINE Suppliers

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View Lastest Price from MEQUITAZINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Mequitazine 29216-28-2
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-08
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Mequitazine 29216-28-2
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98.5%min
Supply Ability
10kg
Release date
2021-08-05
Baoji Guokang Bio-Technology Co., Ltd.
Product
MEQUITAZINE 29216-28-2
Price
US $3015.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
5kg
Release date
2021-06-04

29216-28-2, MEQUITAZINERelated Search:

Mertansine Clindamycin Brompheniramine Trimethobenzamide Danazol Loratadine Antazoline Phenothiazine (R)-(+)-Mequitazine 1-(2,6-DICHLOROPHENYL)-2-INDOLINONE /MEQUITAZINE mequitazine sulfoxide MEQUITAZINE, [2-14C]- pecazine MEQUITAZINE Trimeprazine

  • 10-(1-Azabicyclo[2.2.2]octan-3-ylmethyl)-10H-phenothiazine
  • 10-(Quinuclidin-3-ylmethyl)-10H-phenothiazine
  • MQ-A-88
  • 10-[(1R,3R)-1-azabicyclo[2.2.2]octan-3-ylMethyl]-10H-phenothiazine
  • 10H-Phenothiazine, 10-(1-azabicyclo[2.2.2]oct-3-ylmethyl)- (9CI)
  • Nipolazin
  • NSC 303612
  • Phenothiazine, 10-(3-quinuclidinylmethyl)- (8CI)
  • Quitadrill
  • 10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine
  • 10-(3-Quinuclidinylmethyl)phenothiazine
  • Butix
  • Instotal
  • LM 209
  • Mequitazina
  • Metaplexan
  • Mircol
  • Phenothiazine, 10-(3-quinuclidinylmethyl)-
  • 10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine
  • Primalan
  • Vigigan
  • Virginan
  • Zesulan
  • MEQUITAZINE
  • 10H-PHENOTHIAZINE, 10-(1-AZABICYCLO[2.2.2]OCT-3-YLMETHYL)-
  • MEQUITAZINE USP/EP/BP
  • Indomethacin BP
  • Butix Powder USP Standard
  • 29216-28-2
  • C20H22N2S
  • Heterocyclic Compounds
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals